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REVIEW article

Front. Cell Dev. Biol.
Sec. Cellular Biochemistry
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1464815

Mechanisms of the NAD + Salvage Pathway in Enhancing Skeletal Muscle Function

Provisionally accepted
Mengzhu Su Mengzhu Su 1Fanghui Qiu Fanghui Qiu 1Yansong Li Yansong Li 1Tongtong Che Tongtong Che 1*Ningning Li Ningning Li 1*Shuangshuang Zhang Shuangshuang Zhang 1,2*
  • 1 Qingdao University, Qingdao, China
  • 2 Qingdao Cancer Institute, Qingdao University, Qingdao, Shandong Province, China

The final, formatted version of the article will be published soon.

    Nicotinamide adenine dinucleotide (NAD + ) is crucial for cellular energy production, serving as a coenzyme in oxidation-reduction reactions. It also supports enzymes involved in processes such as DNA repair, aging, and immune responses. Lower NAD+ levels have been associated with various diseases, highlighting the importance of replenishing NAD+. Nicotinamide phosphoribosyltransferase (NAMPT) plays a critical role in the NAD + salvage pathway, which helps sustain NAD + levels, particularly in high-energy tissues like skeletal muscle.This review explores how the NAMPT-driven NAD+ salvage pathway influences skeletal muscle health and functionality in aging, type 2 diabetes mellitus (T2DM), and skeletal muscle injury. The review offers insights into enhancing the salvage pathway through exercise and NAD+ boosters as strategies to improve muscle performance. The findings suggest significant potential for using this pathway in the diagnosis, monitoring, and treatment of skeletal muscle conditions.

    Keywords: NAD+, NAMPT, Skelelal muscle, Aging, T2DM

    Received: 15 Jul 2024; Accepted: 09 Sep 2024.

    Copyright: © 2024 Su, Qiu, Li, Che, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Tongtong Che, Qingdao University, Qingdao, China
    Ningning Li, Qingdao University, Qingdao, China
    Shuangshuang Zhang, Qingdao University, Qingdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.