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REVIEW article

Front. Cell Dev. Biol.
Sec. Cancer Cell Biology
Volume 12 - 2024 | doi: 10.3389/fcell.2024.1423279
This article is part of the Research Topic LncRNAs In Tumor Microenvironment: Its Role in Immunoregulation and Inflammation View all 5 articles

LncRNAs in oncogenic microenvironment: From Threat to Therapy

Provisionally accepted
Dipanjan Roy Dipanjan Roy Rudra Chakravarti Rudra Chakravarti Bireswar Bhattacharya Bireswar Bhattacharya Prabhjot Singh Prabhjot Singh Mansi Arya Mansi Arya Anirban Kundu Anirban Kundu Ajay Patil Ajay Patil Siva Bhukiya Siva Bhukiya Sunny Mehta Sunny Mehta Evan Kazi Evan Kazi Dipanjan Ghosh Dipanjan Ghosh *
  • National Institute of Pharmaceutical Education and Research, Kolkata, Kolkata, West Bengal, India

The final, formatted version of the article will be published soon.

    LncRNAs are molecules of more than 200 nucleotides in length and participate in cellular metabolism and cellular responses through their diverse interactome despite having no proteincoding capabilities. Such significant interactions also implicate the presence of lncRNAs in complex pathobiological pathways of various diseases, affecting cellular survival by modulating autophagy, inflammation and apoptosis. Proliferating cells harbour a complex microenvironment that mainly stimulate growth-specific activities such as DNA replication, repair, and protein synthesis. They also recognise damages at the macromolecular level, preventing them from reaching the next generation. LncRNAs have shown significant association with the events occurring towards proliferation, regulating key events in dividing cells, and dysregulation of lncRNA transcriptome affects normal cellular life-cycle, promoting the development of cancer. Furthermore, lncRNAs also demonstrated an association with cancer growth and progression by regulating key pathways governing cell growth, epithelialmesenchymal transition and metastasis. This makes lncRNAs an attractive target for the treatment of cancer and can also be used as a marker for the diagnosis and prognosis of diseases due to their differential expression in diseased samples. This review delves into the correlation of the lncRNA transcriptome with the fundamental cellular signalling and how this crosstalk shapes the complexity of the oncogenic microhabitat.

    Keywords: lncRNA, Cancer, Tumor Microenvironment, cancer therapy, Inflammation, Apoptosis

    Received: 25 Apr 2024; Accepted: 09 Dec 2024.

    Copyright: © 2024 Roy, Chakravarti, Bhattacharya, Singh, Arya, Kundu, Patil, Bhukiya, Mehta, Kazi and Ghosh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Dipanjan Ghosh, National Institute of Pharmaceutical Education and Research, Kolkata, Kolkata, 700032, West Bengal, India

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.