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REVIEW article
Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
Volume 12 - 2025 | doi: 10.3389/fcvm.2025.1571998
This article is part of the Research Topic Recent Advances in Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) in Heart-Related Diseases: Volume II View all 3 articles
Mitochondria Associated Membranes in Dilated Cardiomyopathy: Connecting Pathogenesis and Cellular Dysfunction
Provisionally accepted- 1 Henan University of Chinese Medicine, Zhengzhou, China
- 2 Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
- 3 Henan Academy of Chinese Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
Dilated cardiomyopathy (DCM) is a leading cause of heart failure, yet therapeutic options remain limited. While traditional research has focused on mechanisms such as energy deficits and calcium dysregulation, increasing evidence suggests that mitochondria-associated membranes (MAMs) could provide new insights into understanding and treating DCM. In this narrative review, we summarize the key role of MAMs, crucial endoplasmic reticulum (ER)-mitochondria interfaces, in regulating cellular processes such as calcium homeostasis, lipid metabolism, and mitochondrial dynamics. Disruption of MAMs function may initiate pathological cascades, including ER stress, inflammation, and cell death. These disruptions in MAM function lead to further destabilization of cellular homeostasis. Identifying MAMs as key modulators of cardiac health may provide novel insights for early diagnosis and targeted therapies in DCM.
Keywords: MAMS, DCM, MAMs-associated proteins, cardiomyocytes, Mitochondrial dysfunction
Received: 06 Feb 2025; Accepted: 27 Feb 2025.
Copyright: © 2025 He, Chang, Qiu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhentao Wang, Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
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