Alterations in Bile Acid Metabolites Associated with Pathogenicity and IVIG Resistance in Kawasaki Disease

Yifei Li ^1* Xinqi Wang ² Linli Han ¹ Jiyang Jiang ² Zhenxin Fan ² Yimin Hua ² Libang He ²

• ¹ West China Second University Hospital, Sichuan University, Chengdu, China
• ² Sichuan University, Chengdu, Sichuan Province, China

Background: Kawasaki disease (KD) primarily affects children as an acute systemic vasculitis. Numerous studies indicated an elevated risk of cardiovascular disease due to metabolic disturbances. Despite this knowledge, the specific metabolic modes involved in KD remain unclear.We examined the metabolome of individuals with 108 KD and 52 non-KD controls (KD vs nKD) by ultraperformance liquid chromatography (UPLC) and tandem mass spectrometry (MS).Results: Differential analysis uncovered the disturbed production of bile acids and lipids in KD. Furthermore, we investigated the impact of treatment, intravenous immunoglobulin (IVIG) resistance, and coronary artery (CA) occurrence on the metabolome. Our findings suggested that IVIG treatment alters the lipid and amino acid metabolism of KD patients. By orthogonal projections to latent structures discriminant analysis (OPLS-DA), there was no significant difference between the coronary injury groups and non-coronary injury groups, and IVIG resistance didn't appear to cause the metabolic change in KD patients.Patients with KD exhibit metabolic abnormalities, particularly in bile acids and lipids. IVIG interventions may partially ameliorate these lipid abnormalities.