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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiac Rhythmology
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1495689

Conduction system pacing versus Biventricular pacing in heart failure with reduced ejection fraction and electrical dyssynchrony

Provisionally accepted
Ahmed Ammar Ahmed Ammar 1*Ahmed Elewa Ahmed Elewa 2Amr Emam Amr Emam 3Mohamed Sharief Mohamed Sharief 4Omnia Kamel Omnia Kamel 3
  • 1 Worcestershire Health and Care NHS Trust, Worcester, United Kingdom
  • 2 Faculty of Medicine, Ain Shams University, Cairo, Beni Suef, Egypt
  • 3 Magdi Yacoub Heart Foundation-Aswan Heart Centre, Cairo, Beni Suef, Egypt
  • 4 Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom

The final, formatted version of the article will be published soon.

    Biventricular pacing (BiVP) has been the cornerstone of Cardiac resynchronization therapy (CRT) in management of symptomatic heart failure patients with reduced ejection fraction (HFrEF) and electrical dyssynchrony despite guideline-directed medical therapy (GDMT). However, BiVP has some limitations, including technical difficulties and high non-response rates. Conduction system pacing encompassing His bundle pacing (HBP) and left bundle area pacing (LBAP) has recently emerged as promising possible alternative to CRT in this group of patients. In this review, we explore the current evidence, guidelines, limitations, gaps in knowledge and ongoing trials for CSP versus CRT for management of HFrEF with electrical dyssynchrony.

    Keywords: RVs-LVs, right ventricle sensed-left ventricle sensed interval UHF-ECG, Ultra-High-Frequency ECG VF, Ventricular fibrillation VT, ventricular tachycardia

    Received: 13 Sep 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Ammar, Elewa, Emam, Sharief and Kamel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ahmed Ammar, Worcestershire Health and Care NHS Trust, Worcester, United Kingdom

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.