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REVIEW article

Front. Cardiovasc. Med.
Sec. Cardiovascular Metabolism
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1489438
This article is part of the Research Topic Inflammatory Microenvironment in Metabolic Cardiovascular Disease: Mechanisms, Biomarkers, and Therapeutic Implications View all articles

Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets

Provisionally accepted
Han Zhang Han Zhang Jiulu Zhao Jiulu Zhao Jizhang Yu Jizhang Yu Xi Zhang Xi Zhang Shuan Ran Shuan Ran *Song Wang Song Wang Weicong Ye Weicong Ye *Zilong Luo Zilong Luo *Xiaohan Li Xiaohan Li Yanglin Hao Yanglin Hao *Junjie Zong Junjie Zong *Ran Li Ran Li *Longyong Lai Longyong Lai *Zheng Kexiao Zheng Kexiao Pinyan Huang Pinyan Huang *Cheng Zhou Cheng Zhou Jie Wu Jie Wu *Yuan Li Yuan Li *Jiahong Xia Jiahong Xia *
  • Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China

The final, formatted version of the article will be published soon.

    Cardiovascular disease (CVD) is responsible for approximately 30% of annual global mortality rates, yet existing treatments for this condition are considered less than ideal. Despite being previously overlooked, lactate, a byproduct of glycolysis, is now acknowledged for its crucial role in the cellular functions of the cardiovascular system. Recent studies have shown that lactate influences the proliferation, differentiation, and activation of immune cells through its modulation of posttranslational protein modifications, thereby affecting the development and prognosis of cardiovascular disease. Consequently, there has been a notable increase in interest towards drug targets targeting lactylation in immune cells, prompting further exploration. In light of the swift advancements in this domain, this review article is dedicated to examining lactylation in cardiovascular disease and potential drug targets for regulating lactylation, with the aim of enhancing comprehension of this intricate field.

    Keywords: Lactate metabolism1, Lactylation2, Immune cell3, cardiovascular disease4, Glycolysis5

    Received: 01 Sep 2024; Accepted: 11 Nov 2024.

    Copyright: © 2024 Zhang, Zhao, Yu, Zhang, Ran, Wang, Ye, Luo, Li, Hao, Zong, Li, Lai, Kexiao, Huang, Zhou, Wu, Li and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shuan Ran, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Weicong Ye, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Zilong Luo, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Yanglin Hao, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Junjie Zong, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Ran Li, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Longyong Lai, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Pinyan Huang, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Jie Wu, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Yuan Li, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China
    Jiahong Xia, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.