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REVIEW article

Front. Cardiovasc. Med.
Sec. Clinical and Translational Cardiovascular Medicine
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1493290

Cardiac cells and mesenchymal stem cells derived extracellular vesicles: a potential therapeutic strategy for myocardial infarction

Provisionally accepted
Dan Qin Dan Qin 1Xiaobo Wang Xiaobo Wang 1Jun Pu Jun Pu 1Houxiang Hu Houxiang Hu 1,2*
  • 1 Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
  • 2 Academician Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

The final, formatted version of the article will be published soon.

    Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies. Extracellular vesicles (EVs) carry proteins and noncoding RNAs (ncRNAs) derived from different cardiac cell populations, mainly including cardiomyocytes, endothelial cells, endothelial progenitor cells, cardiac progenitor cells, cardiospherederived cells, immune cells, fibroblasts and cardiac telocytes have vital roles under both physiological and pathological process such as myocardial infarction (MI). The content of EVs can also indicate the status of their parental cells and serve as a biomarker for monitoring the risk of cardiac injury. Examining these vesicles can offer fresh perspectives on the development of MI and assist in creating innovative treatments. Additionally, mesenchymal stem cells (MSCs) (MSC-EVs) derived EVs have been shown to have significant potential in cardiac regeneration. In this review, we will discuss the current understanding of the role of EVs in cardiac communication, with a focus on the perspectives of EVs from various cardiac cells and MSCs for their potential uses as cardiac therapies after MI.

    Keywords: Myocardial Infarction, cardiac cells, cell-cell communication, Mesenchymal Stem Cells, extracellular vesicles

    Received: 08 Sep 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Qin, Wang, Pu and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Houxiang Hu, Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.