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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Coronary Artery Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1479506
This article is part of the Research Topic Optimizing Revascularization and Conservative Therapy in Chronic Coronary Syndrome View all 5 articles

Safety analysis of brachial artery sheath removal after heparin reversal with a half dose of protamine after percutaneous coronary intervention: A single-center experience

Provisionally accepted
Huanhuan Wang Huanhuan Wang 1*Cheng Cui Cheng Cui 1Dan Liu Dan Liu 2Hongmei Liu Hongmei Liu 2Tao Tian Tao Tian 1Ming-hao Liu Ming-hao Liu 1Bo Zhang Bo Zhang 3Tongqiang Zou Tongqiang Zou 1Zhan Gao Zhan Gao 1Lijian Gao Lijian Gao 1Haibo Liu Haibo Liu 1
  • 1 Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China, Beijing, China
  • 2 Shihezi People's Hospital, The Third Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang Uyghur Region, China
  • 3 Yunnan Fuwai Cardiovascular Hospital, Kunming, Yunnan Province, China

The final, formatted version of the article will be published soon.

    Aim: To evaluate the safety of brachial artery (BA) sheath removal after heparin neutralization with a half dose of protamine immediately after percutaneous coronary intervention (PCI).The clinical data of 209 consecutive patients who underwent PCI through the BA at Fu Wai Hospital between September 2019 and June 2024 were retrospectively collected. In group I, the brachial sheath was removed 4 hours after the PCI procedure. In group II, circulating heparin was neutralized with a half dose of protamine sulfate, and the brachial sheath was removed immediately after the procedure.Results: There were no cases of acute stent thrombosis, nonfatal myocardial infarction or in-hospital mortality in either group. In group II, there were two cases of pseudoaneurysm, one of which was transfer to surgery and the other was manually compressed. No severe puncture site-related bleeding occurred. The levels of hemoglobin were similar between the two groups before and after the PCI procedure (p>0.05).The BA sheath can be safely removed immediately after PCI by neutralizing heparin with a half dose of protamine. But we still need to be vigilant about the occurrence of pseudoaneurysms.

    Keywords: Brachial Artery, Heparin, protamine, Percutaneous Coronary Intervention, Safety

    Received: 12 Aug 2024; Accepted: 12 Nov 2024.

    Copyright: © 2024 Wang, Cui, Liu, Liu, Tian, Liu, Zhang, Zou, Gao, Gao and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Huanhuan Wang, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.