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ORIGINAL RESEARCH article

Front. Cardiovasc. Med.
Sec. Hypertension
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1326348

Study of the causal relationship between gastroesophageal reflux disease and hypertension through two-sample Mendelian randomization analysis

Provisionally accepted
Weige Li Weige Li 1Qian Wang Qian Wang 1Wenjie Li Wenjie Li 1Xiang Liu Xiang Liu 1Zuobin Li Zuobin Li 1Qi Dai Qi Dai 2*
  • 1 Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China
  • 2 Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China

The final, formatted version of the article will be published soon.

    Objective: The purpose of this study was to investigate the causal relationship between gastroesophageal reflux disease (GERD) and hypertension using a two-sample Mendelian randomization analysis. Methods: The associated data of GERD with hypertension were derived from the genome-wide association study (GWAS) database, and two-sample Mendelian randomization (MR) analysis was performed using methods including inverse variance weighting (IVW), MR-Egger, and weighted median (WM) to investigate the causal association between GERD and hypertension. Results A total of 16 single nucleotide polymorphisms (SNPs) strongly associated with GERD were screened out, and the IVW suggested a causal relationship between GERD and hypertension (OR: 1.057; 95% CI: 1.044–1.071; P < 0.05). The weighted median also showed a similar relationship (OR: 1.051, 95% CI: 1.032–1.07; P < 0.05). In addition, no heterogeneity or horizontal pleiotropy was observed, suggesting a robustness of the outcome. Conclusion: There is a positive causal relationship between GERD and hypertension.

    Keywords: causal inference, Gastroesophageal reflux disease, Hypertension, Mendelian randomization, Gastroenterology

    Received: 23 Oct 2023; Accepted: 05 Sep 2024.

    Copyright: © 2024 Li, Wang, Li, Liu, Li and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Qi Dai, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China

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