AUTHOR=Li Weige , Wang Qian , Li Wenjie , Liu Xiang , Li Zuobin , Dai Qi 

TITLE=Study of the causal relationship between gastroesophageal reflux disease and hypertension through two-sample Mendelian randomization analysis

JOURNAL=Frontiers in Cardiovascular Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1326348

DOI=10.3389/fcvm.2024.1326348

ISSN=2297-055X

ABSTRACT=<sec><title>Objective</title><p>The purpose of this study was to investigate the causal relationship between gastroesophageal reflux disease (GERD) and hypertension using a two-sample Mendelian randomization analysis.</p></sec><sec><title>Methods</title><p>The associated data of GERD with hypertension were derived from the genome-wide association study (GWAS) database, and two-sample Mendelian randomization (MR) analysis was performed using methods including inverse variance weighting (IVW), MR-Egger, and weighted median (WM) to investigate the causal association between GERD and hypertension.</p></sec><sec><title>Results</title><p>A total of 16 single nucleotide polymorphisms (SNPs) strongly associated with GERD were screened out, and the IVW suggested a causal relationship between GERD and hypertension (OR: 1.057; 95% CI: 1.044–1.071; <italic>P</italic> &lt; 0.05). The weighted median also showed a similar relationship (OR: 1.051, 95% CI: 1.032–1.07; <italic>P</italic> &lt; 0.05). In addition, no heterogeneity or horizontal pleiotropy was observed, suggesting a robustness of the outcome.</p></sec><sec><title>Conclusion</title><p>There is a positive causal relationship between GERD and hypertension.</p></sec>