Frontiers in Bioengineering and Biotechnology | Organoids and Organ-On-A-Chip

Review

Accepted on 12 Feb 2025

Organoids-on-a-Chip: Microfluidic Technology Enables Culture of Organoids with Enhanced Tissue Function and Potential for Disease Modeling

in Organoids and Organ-On-A-Chip

Lito Papamichail
Lena Sophie Koch
Devin Veerman
Kerensa Broersen
Andries Van Der Meer

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1515340

180 views

Mini Review

Published on 27 Jan 2025

In silico modelling of organ-on-a-chip devices: an overview

in Organoids and Organ-On-A-Chip

Yue Wang
Lucia Marucci
Martin E. Homer

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1520795

543 views

Review

Published on 07 Jan 2025

The utilisation of biliary organoids for biomedical applications

in Organoids and Organ-On-A-Chip

Zhongwen Lei
Yijun Yang
Yang Xiang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1501829

572 views

Review

Published on 07 Jan 2025

Microfluidic organ-on-chip systems for periodontal research: advances and future directions

in Organoids and Organ-On-A-Chip

Gopu Sriram
Hardik Makkar

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1490453

845 views

Methods

Published on 18 Dec 2024

Rapid and reproducible generation of glioblastoma spheroids for high-throughput drug screening

in Organoids and Organ-On-A-Chip

Christian Bach
Annegret Glasow
Rainer Baran-Schmidt
Henry Oppermann
Christoph Bach
Jürgen Meixensberger
Erdem Güresir
Frank Gaunitz

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1471012

689 views

Original Research

Published on 16 Dec 2024

Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model

in Organoids and Organ-On-A-Chip

Angelo Massaro
Cecilia Villegas Novoa
Yuli Wang
Nancy L. Allbritton

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1506976

1,049 views
1 citation

Original Research

Published on 11 Nov 2024

Non-invasive real-time investigation of colorectal cells tight junctions by Raman microspectroscopy analysis combined with machine learning algorithms for organ-on-chip applications

in Organoids and Organ-On-A-Chip

A. Calogiuri
D. Bellisario
E. Sciurti
L. Blasi
V. Esposito
F. Casino
P. Siciliano
L. Francioso

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1458404

933 views

Original Research

Published on 08 Oct 2024

Assessing the metastatic potential of circulating tumor cells using an organ-on-chip model

in Organoids and Organ-On-A-Chip

Karin F. Schmid
Soheila Zeinali
Susanne K. Moser
Christelle Dubey
Sabine Schneider
Haibin Deng
Simon Haefliger
Thomas M. Marti
Olivier T. Guenat

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1457884

1,560 views

Original Research

Published on 02 Oct 2024

A millifluidic bioreactor allows the long term culture of primary lymphocytes or CD34+ hematopoietic cells while allowing the detection of tumorigenic expansion

in Organoids and Organ-On-A-Chip

Paolo Ritter
Stefania Oliveto
Chiara Cordiglieri
Alessandra Fasciani
Christian Andrea Di Buduo
Lucrezia della Volpe
Alberto Bocconi
Claudio Conci
Carolina Paula Miguel
Raffaella Di Micco

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1388312

1,513 views

Review

Published on 02 Oct 2024

Tumor-on-chip platforms for breast cancer continuum concept modeling

in Organoids and Organ-On-A-Chip

Anca-Narcisa Neagu
Danielle Whitham
Pathea Bruno
Nicholas Versaci
Peter Biggers
Costel C. Darie

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1436393

1,910 views

Review

Published on 25 Sep 2024

Improving tumor microenvironment assessment in chip systems through next-generation technology integration

in Organoids and Organ-On-A-Chip

Daniela Gaebler
Stephanie J. Hachey
Christopher C. W. Hughes

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1462293

1,836 views

Editorial

Published on 25 Sep 2024

Editorial: Emerging bioanalytical techniques and therapies for human disease models

in Organoids and Organ-On-A-Chip

Xuerui Wang
Jinnuo Lu
Yixiao Huang
Xinhao Liu
Guocheng Fang
Chih-Tsung Yang
Zhaobin Guo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1453813

763 views

Original Research

Published on 06 Sep 2024

Bidirectionally validated in silico and in vitro formation of specific depth zone-derived chondrocyte spheroids and clusters

in Organoids and Organ-On-A-Chip

Eiichiro Takada
Hayato L. Mizuno
Yoshiki Takeoka
Shuichi Mizuno

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1440434

1,608 views

Original Research

Published on 02 Aug 2024

A multiparametric analysis including single-cell and subcellular feature assessment reveals differential behavior of spheroid cultures on distinct ultra-low attachment plate types

in Organoids and Organ-On-A-Chip

Mario Vitacolonna
Roman Bruch
Ane Agaçi
Elina Nürnberg
Tiziana Cesetti
Florian Keller
Francesco Padovani
Simeon Sauer
Kurt M. Schmoller
Markus Reischl

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1422235

2,633 views
1 citation

Original Research

Published on 25 Jun 2024

Optimization and validation of a fat-on-a-chip model for non-invasive therapeutic drug discovery

in Organoids and Organ-On-A-Chip

Lindsey K. Huff
Charles M. Amurgis
Lauren E. Kokai
Rosalyn D. Abbott

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1404327

1,822 views
1 citation

Original Research

Published on 12 Jun 2024

Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling

in Organoids and Organ-On-A-Chip

Chencheng Wang
Shadab Abadpour
Aleksandra Aizenshtadt
Andrea Dalmao-Fernandez
Merete Høyem
Ingrid Wilhelmsen
Justyna Stokowiec
Petter Angell Olsen
Stefan Krauss
Simona Chera

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2024.1392575

2,045 views
1 citation

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Articles

Organoids-on-a-Chip: Microfluidic Technology Enables Culture of Organoids with Enhanced Tissue Function and Potential for Disease Modeling

In silico modelling of organ-on-a-chip devices: an overview

The utilisation of biliary organoids for biomedical applications

Microfluidic organ-on-chip systems for periodontal research: advances and future directions

Rapid and reproducible generation of glioblastoma spheroids for high-throughput drug screening

Fibroblasts modulate epithelial cell behavior within the proliferative niche and differentiated cell zone within a human colonic crypt model

Non-invasive real-time investigation of colorectal cells tight junctions by Raman microspectroscopy analysis combined with machine learning algorithms for organ-on-chip applications

Assessing the metastatic potential of circulating tumor cells using an organ-on-chip model

A millifluidic bioreactor allows the long term culture of primary lymphocytes or CD34+ hematopoietic cells while allowing the detection of tumorigenic expansion

Tumor-on-chip platforms for breast cancer continuum concept modeling

Improving tumor microenvironment assessment in chip systems through next-generation technology integration

Editorial: Emerging bioanalytical techniques and therapies for human disease models

Bidirectionally validated in silico and in vitro formation of specific depth zone-derived chondrocyte spheroids and clusters

A multiparametric analysis including single-cell and subcellular feature assessment reveals differential behavior of spheroid cultures on distinct ultra-low attachment plate types

Optimization and validation of a fat-on-a-chip model for non-invasive therapeutic drug discovery

Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling