Review

Published on 22 Jun 2022

Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions

in Cell and Gene Therapy

Alaa Alnefaie
Sarah Albogami
Yousif Asiri
Tanveer Ahmad
Saqer S. Alotaibi
Mohammad M. Al-Sanea
Hisham Althobaiti

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.797440

31,529 views
60 citations

Review

Published on 15 Jun 2022

A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis

in Cell and Gene Therapy

Mario Rothbauer
Eva I. Reihs
Anita Fischer
Reinhard Windhager
Florien Jenner
Stefan Toegel

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.886360

7,135 views
6 citations

Original Research

Published on 14 Jun 2022

The Role of Hypoxia in Improving the Therapeutic Potential of Mesenchymal Stromal Cells. A Comparative Study From Healthy Lung and Congenital Pulmonary Airway Malformations in Infants

in Cell and Gene Therapy

Serena Silvestro
Francesca Diomede
Luigi Chiricosta
Valeria Domenica Zingale
Guya Diletta Marconi
Jacopo Pizzicannella
Andrea Valeri
Maria Antonietta Avanzini
Valeria Calcaterra
Gloria Pelizzo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.868486

2,303 views
4 citations

Original Research

Published on 03 Jun 2022

Improving Control of Gene Therapy-Based Neurotrophin Delivery for Inner Ear Applications

in Cell and Gene Therapy

Madeleine St. Peter
Douglas E. Brough
Anna Lawrence
Jennifer Nelson-Brantley
Peixin Huang
Jennifer Harre
Athanasia Warnecke
Hinrich Staecker

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.892969

2,920 views
5 citations

Original Research

Published on 02 Jun 2022

Identification of Type 2 Diabetes Biomarkers From Mixed Single-Cell Sequencing Data With Feature Selection Methods

in Cell and Gene Therapy

Zhandong Li
Xiaoyong Pan
Yu-Dong Cai

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.890901

3,576 views
8 citations

Original Research

Published on 01 Jun 2022

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modulate Hematopoietic Stem and Progenitor Cell Viability and the Expression of Cell Cycle Regulators in an Age-dependent Manner

in Cell and Gene Therapy

Pascal Fichtel
Malte von Bonin
Robert Kuhnert
Kristin Möbus
Martin Bornhäuser
Manja Wobus

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.892661

3,912 views
15 citations

Original Research

Published on 30 May 2022

Identifying In Vitro Cultured Human Hepatocytes Markers with Machine Learning Methods Based on Single-Cell RNA-Seq Data

in Cell and Gene Therapy

ZhanDong Li
FeiMing Huang
Lei Chen
Tao Huang
Yu-Dong Cai

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.916309

3,943 views
3 citations

Review

Published on 27 May 2022

The Hunt Is On! In Pursuit of the Ideal Stem Cell Population for Cartilage Regeneration

in Cell and Gene Therapy

T. Mark Campbell
F. Jeffrey Dilworth
David S. Allan
Guy Trudel

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.866148

5,170 views
7 citations

Systematic Review

Published on 26 May 2022

Pre-Eclampsia Biomarkers for Women With Type 1 Diabetes Mellitus: A Comprehensive Review of Recent Literature

in Cell and Gene Therapy

Katrina Z. Freimane
Lauren Kerrigan
Kelly-Ann Eastwood
Chris J. Watson

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.809528

3,534 views
2 citations

Original Research

Published on 26 May 2022

Stabilizing and Anti-Repressor Elements Effectively Increases Transgene Expression in Transfected CHO Cells

in Cell and Gene Therapy

Qin Li
Rui-Fang Yan
Yong-Xiao Yang
Chun-liu Mi
Yan-long Jia
Tian-Yun Wang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.840600

3,078 views
4 citations

Review

Published on 25 May 2022

Advances in Stem Cell Therapies for Rotator Cuff Injuries

in Cell and Gene Therapy

Hao-Nan Wang
Xiao Rong
Lu-Ming Yang
Wei-Zhong Hua
Guo-Xin Ni

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.866195

26,272 views
14 citations

Original Research

Published on 20 May 2022

Changes in Elastic Moduli of Fibrin Hydrogels Within the Myogenic Range Alter Behavior of Murine C2C12 and Human C25 Myoblasts Differently

in Cell and Gene Therapy

Janine Tomasch
Babette Maleiner
Philipp Heher
Manuel Rufin
Orestis G. Andriotis
Philipp J. Thurner
Heinz Redl
Christiane Fuchs
Andreas H. Teuschl-Woller

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.836520

4,128 views
7 citations

Review

Published on 19 May 2022

Non-Coding RNAs Delivery by Small Extracellular Vesicles and Their Applications in Ovarian Cancer

in Cell and Gene Therapy

Mu Liu
Xiaofang Zhou
Jie Tang

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.876151

2,737 views
2 citations

Original Research

Published on 13 May 2022

Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer

in Cell and Gene Therapy

Leijie Li
Yujia Zhang
Yongyong Ren
Zhiwei Cheng
Yuening Zhang
Xinbo Wang
Hongyu Zhao
Hui Lu

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.849798

3,296 views
5 citations

Mini Review

Published on 12 May 2022

Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges

in Cell and Gene Therapy

Misganaw Asmamaw Mengstie

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.895713

24,898 views
60 citations

Original Research

Published on 12 May 2022

Identification of a Pyroptosis-Related Gene Signature for Predicting the Immune Status and Prognosis in Lung Adenocarcinoma

in Cell and Gene Therapy

Zetian Gong
Qifan Li
Jian Yang
Pengpeng Zhang
Wei Sun
Qianhe Ren
Junjie Tang
Wei Wang
Hui Gong
Jun Li

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2022.852734

3,867 views
18 citations

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Articles

Chimeric Antigen Receptor T-Cells: An Overview of Concepts, Applications, Limitations, and Proposed Solutions

A Progress Report and Roadmap for Microphysiological Systems and Organ-On-A-Chip Technologies to Be More Predictive Models in Human (Knee) Osteoarthritis

The Role of Hypoxia in Improving the Therapeutic Potential of Mesenchymal Stromal Cells. A Comparative Study From Healthy Lung and Congenital Pulmonary Airway Malformations in Infants

Improving Control of Gene Therapy-Based Neurotrophin Delivery for Inner Ear Applications

Identification of Type 2 Diabetes Biomarkers From Mixed Single-Cell Sequencing Data With Feature Selection Methods

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modulate Hematopoietic Stem and Progenitor Cell Viability and the Expression of Cell Cycle Regulators in an Age-dependent Manner

Identifying In Vitro Cultured Human Hepatocytes Markers with Machine Learning Methods Based on Single-Cell RNA-Seq Data

The Hunt Is On! In Pursuit of the Ideal Stem Cell Population for Cartilage Regeneration

Pre-Eclampsia Biomarkers for Women With Type 1 Diabetes Mellitus: A Comprehensive Review of Recent Literature

Stabilizing and Anti-Repressor Elements Effectively Increases Transgene Expression in Transfected CHO Cells

Advances in Stem Cell Therapies for Rotator Cuff Injuries

Changes in Elastic Moduli of Fibrin Hydrogels Within the Myogenic Range Alter Behavior of Murine C2C12 and Human C25 Myoblasts Differently

Non-Coding RNAs Delivery by Small Extracellular Vesicles and Their Applications in Ovarian Cancer

Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer

Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges

Identification of a Pyroptosis-Related Gene Signature for Predicting the Immune Status and Prognosis in Lung Adenocarcinoma