Systematic Review

Published on 17 Mar 2021

Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

in Cell and Gene Therapy

Piers Wilkinson
Ilya Y. Bozo
Thomas Braxton
Peter Just
Elena Jones
Roman V. Deev
Peter V. Giannoudis
Georg A. Feichtinger

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.626315

5,048 views
6 citations

Original Research

Published on 09 Mar 2021

Optimizing Granulocyte Colony-Stimulating Factor Transcript for Enhanced Expression in Escherichia coli

in Cell and Gene Therapy

Sonal Datta

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.630367

5,780 views
1 citation

Original Research

Published on 25 Feb 2021

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

in Cell and Gene Therapy

Corina A. Ghebes
Jess Morhayim
Marion Kleijer
Merve Koroglu
Stefan J. Erkeland
Remco Hoogenboezem
Eric Bindels
Floris P. J. van Alphen
Maartje van den Biggelaar
Martijn A. Nolte

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.640419

6,443 views
12 citations

Original Research

Published on 15 Feb 2021

miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells

in Cell and Gene Therapy

Enrico Ragni
Alessandra Colombini
Paola De Luca
Francesca Libonati
Marco Viganò
Carlotta Perucca Orfei
Luigi Zagra
Laura de Girolamo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.632440

7,113 views
20 citations

Review

Published on 12 Feb 2021

Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications

in Cell and Gene Therapy

Dimitrios Kouroupis
Diego Correa

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.621748

18,163 views
80 citations

Review

Published on 05 Feb 2021

Extracellular Vesicles From Perinatal Cells for Anti-inflammatory Therapy

in Cell and Gene Therapy

Anna Cargnoni
Andrea Papait
Alice Masserdotti
Anna Pasotti
Francesca Romana Stefani
Antonietta Rosa Silini
Ornella Parolini

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.637737

6,844 views
22 citations

Original Research

Published on 05 Feb 2021

Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells

in Cell and Gene Therapy

Carola Schmitz
Ekaterina Potekhina
Teresa Irianto
Vsevolod V. Belousov
Antonina Lavrentieva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.611837

8,837 views
35 citations

Original Research

Published on 04 Feb 2021

Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside

in Cell and Gene Therapy

Ilia Y. Bozo
Alexey Y. Drobyshev
Nikolay A. Redko
Vladimir S. Komlev
Artur A. Isaev
Roman V. Deev

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2021.599300

5,493 views
23 citations

Original Research

Published on 21 Jan 2021

Scalable Production of Equine Platelet Lysate for Multipotent Mesenchymal Stromal Cell Culture

in Cell and Gene Therapy

A. Hagen
H. Lehmann
S. Aurich
N. Bauer
M. Melzer
J. Moellerberndt
V. Patané
C. L. Schnabel
J. Burk

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.613621

5,291 views
19 citations

Review

Published on 20 Jan 2021

Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration

in Cell and Gene Therapy

Marietta Herrmann
Solvig Diederichs
Svitlana Melnik
Jana Riegger
Drenka Trivanović
Shushan Li
Zsuzsa Jenei-Lanzl
Rolf E. Brenner
Markus Huber-Lang
Frank Zaucke

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.624096

8,182 views
29 citations

Original Research

Published on 15 Jan 2021

Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

in Cell and Gene Therapy

Marline Kirsch
Jessica Rach
Wiebke Handke
Axel Seltsam
Iliyana Pepelanova
Sarah Strauß
Peter Vogt
Thomas Scheper
Antonina Lavrentieva

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.598389

10,485 views
34 citations

Original Research

Published on 15 Jan 2021

Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway

in Cell and Gene Therapy

Chenyu Liang
Yang Liu
Huifeng Xu
Junling Huang
Yi Shen
Faxiu Chen
Ming Luo

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.615850

9,192 views
40 citations

Mini Review

Published on 13 Jan 2021

Non-viral Gene Therapy for Osteoarthritis

in Cell and Gene Therapy

Ilona Uzieliene
Ursule Kalvaityte
Eiva Bernotiene
Ali Mobasheri

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.618399

13,188 views
31 citations

Original Research

Published on 23 Dec 2020

Influence of Extracellular Vesicles Isolated From Osteoblasts of Patients With Cox-Arthrosis and/or Osteoporosis on Metabolism and Osteogenic Differentiation of BMSCs

in Cell and Gene Therapy

Tanja Niedermair
Christoph Lukas
Shushan Li
Sabine Stöckl
Benjamin Craiovan
Christoph Brochhausen
Marianne Federlin
Marietta Herrmann
Susanne Grässel

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.615520

6,715 views
26 citations

Original Research

Published on 23 Dec 2020

RA-UNet: A Hybrid Deep Attention-Aware Network to Extract Liver and Tumor in CT Scans

in Cell and Gene Therapy

Qiangguo Jin
Zhaopeng Meng
Changming Sun
Hui Cui
Ran Su

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.605132

20,670 views
315 citations

Original Research

Published on 14 Dec 2020

hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways

in Cell and Gene Therapy

Shushan Li
Sabine Stöckl
Christoph Lukas
Julia Götz
Marietta Herrmann
Marianne Federlin
Susanne Grässel

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2020.603598

6,097 views
36 citations

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Articles

Systematic Review of the Preclinical Technology Readiness of Orthopedic Gene Therapy and Outlook for Clinical Translation

Optimizing Granulocyte Colony-Stimulating Factor Transcript for Enhanced Expression in Escherichia coli

Extracellular Vesicles Derived From Adult and Fetal Bone Marrow Mesenchymal Stromal Cells Differentially Promote ex vivo Expansion of Hematopoietic Stem and Progenitor Cells

miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells

Increased Mesenchymal Stem Cell Functionalization in Three-Dimensional Manufacturing Settings for Enhanced Therapeutic Applications

Extracellular Vesicles From Perinatal Cells for Anti-inflammatory Therapy

Hypoxia Onset in Mesenchymal Stem Cell Spheroids: Monitoring With Hypoxia Reporter Cells

Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside

Scalable Production of Equine Platelet Lysate for Multipotent Mesenchymal Stromal Cell Culture

Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration

Comparative Analysis of Mesenchymal Stem Cell Cultivation in Fetal Calf Serum, Human Serum, and Platelet Lysate in 2D and 3D Systems

Exosomes of Human Umbilical Cord MSCs Protect Against Hypoxia/Reoxygenation-Induced Pyroptosis of Cardiomyocytes via the miRNA-100-5p/FOXO3/NLRP3 Pathway

Non-viral Gene Therapy for Osteoarthritis

Influence of Extracellular Vesicles Isolated From Osteoblasts of Patients With Cox-Arthrosis and/or Osteoporosis on Metabolism and Osteogenic Differentiation of BMSCs

RA-UNet: A Hybrid Deep Attention-Aware Network to Extract Liver and Tumor in CT Scans

hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways