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BRIEF RESEARCH REPORT article

Front. Bioeng. Biotechnol.
Sec. Biomaterials
Volume 12 - 2024 | doi: 10.3389/fbioe.2024.1515043
This article is part of the Research Topic Advanced Functional Materials for Disease Diagnosis, Drug Delivery and Tissue Repair View all 11 articles

Rational construction of PCL-PEG/CS/AST nanofiber for bone repair and regeneration

Provisionally accepted
Zhengyu Cao Zhengyu Cao 1*Hongwu Zhuo Hongwu Zhuo 1*Wendong Zhu Wendong Zhu 2*Xiangfang Peng Xiangfang Peng 2*Jian Li Jian Li 1*
  • 1 The Second Affiliated Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
  • 2 Fujian University of Technology, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Humerus greater tuberosity (HGT) avulsion fracture is one of the most common types of proximal humerus fractures. The presence of motion and gap lead to the failure of implants, due to the force pulling from the supraspinatus. In this work, electrospinning technology was applied to fabricate PCL-PEG/CS/AST nanofiber with superior biocompatibility and mechanical property. Furthermore, PCL-PEG/CS/AST nanofiber could promote proliferation and osteogenic differentiation of bone mesenchymal stem cells (BMSCs) in vitro. We believe that this work indicates a promising way to promote the union of HGT avulsion fractures by using PCL-PEG/CS/AST nanofiber.

    Keywords: Electrospinning, nanofiber, Humerus, Bone, tuberosity

    Received: 22 Oct 2024; Accepted: 27 Dec 2024.

    Copyright: © 2024 Cao, Zhuo, Zhu, Peng and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhengyu Cao, The Second Affiliated Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, 350003, Fujian Province, China
    Hongwu Zhuo, The Second Affiliated Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, 350003, Fujian Province, China
    Wendong Zhu, Fujian University of Technology, Fuzhou, 130012, Fujian Province, China
    Xiangfang Peng, Fujian University of Technology, Fuzhou, 130012, Fujian Province, China
    Jian Li, The Second Affiliated Hospital, Fujian University of Traditional Chinese Medicine, Fuzhou, 350003, Fujian Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.