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ORIGINAL RESEARCH article
Front. Allergy
Sec. Food Allergy
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1568595
Effect of seasonal exposure in aeroallergen-sensitized patients with irritable bowel syndrome-diarrhoea
Provisionally accepted
Carlo Maria Rossi*
Marco Vincenzo Lenti
Stefania Merlimartina fioritaantonio lobelloandrea latorrenicola aronicopaola ilaria bianchi
Annalisa De Silvestri
Antonio Di Sabatino- Department of Internal Medicine, San Matteo Hospital Foundation (IRCCS), Pavia, Italy
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Background. Pollen allergy may have an influence on irritable bowel syndrome (IBS) symptoms, but data are scant. Aims. To assess symptom variability in atopic IBS patients. Methods. We retrospectively analysed consecutive adult IBS patients evaluated in 2021-2024. Patients from the overall IBS cohort and the IBS-diarrhoea (IBS-D) subgroup were classified according to their sensitization into Grasses positive, House-dust mite (HDM) positive or unsensitised. Symptom burden was assessed with the gastrointestinal symptom rating scale (GSRS) and visual analogue scale (VAS) for abdominal pain/distension out of the season period (T0) and at the pollination season (T1). Results. Overall, 61 IBS (median age 34 years, IQR 25-50, F:M ratio 3.6:1) of whom 38 (62.8%) IBS-D (median age 30 years, IQR,28-47, F:M ratio 2.8:1) patients were recruited. Atopy was common in the IBS-D subgroup, particularly respiratory manifestations. The mean GSRS significantly (p<0.01) increased at T1 (variance of 3.4 points) only in Grass-sensitized patients as opposed to those sensitized to HDM or unsensitised ones and this effect was present only in the IBS-D subgroup, while in the overall cohort no significant variation was observed. Conclusions. Pollination season has an influence on symptoms in IBS-D patients sensitized to seasonal allergens.
Keywords: bowel, irritable bowel syndrome, mast cell, Pollinosis, Season, bowel, Irritable bowel disease
Received: 30 Jan 2025; Accepted: 11 Apr 2025.
Copyright: © 2025 Rossi, Lenti, Merli, fiorita, lobello, latorre, aronico, bianchi, De Silvestri and Di Sabatino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Carlo Maria Rossi, Department of Internal Medicine, San Matteo Hospital Foundation (IRCCS), Pavia, Italy
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