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CLINICAL TRIAL article
Front. Allergy
Sec. Therapies and Therapeutic Targets
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1559201
This article is part of the Research TopicAllergic Diseases Through Precision MedicineView all articles
A Randomized Controlled Trial Evaluating Prophylactic Treatment of Artemisia Pollinosis Using Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray
Provisionally accepted- 1Peking Union Medical College Hospital (CAMS), Beijing, China
- 2the First Affiliated Hospital of Xi’an Jiaotong University, Yulin Hospital, Yulin, China
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Background: Prophylactic treatment for pollinosis is advantageous for managing nasal symptoms in patients with seasonal allergic rhinitis. Inadequate control of rhinitis symptoms increases the risk of acute asthma attacks. Nevertheless, there is limited research on the use of nasal glucocorticoids and antihistamines for the preventive treatment of pollinosis.Objective: This study aimed to assess the efficacy of prophylactic treatment for nasal symptoms and acute asthma attacks by enrolling patients with Artemisia pollinosis to use a combined device of azelastine hydrochloride and fluticasone nasal spray prior to the pollen season.Methods: The study was registered at Chictr.org.cn (ChiCTR2300073758). A total of 120 patients with Artemisia pollinosis were randomly assigned to either a prophylactic treatment group or a control group at a 1:1 ratio. In the prophylactic treatment group, the nasal spray was initiated approximately two weeks before the onset of the pollen season.Results: During both the pollen season and the concurrent medication period, the prophylactic treatment group presented significantly lower total nasal symptom scores (TNSS) (means of 5.97 and 5.94) than the control group (means of 7.86 and 7.80) (P = 0.015 and 0.016). Although the prophylactic treatment group had a lower asthma attack rate than the control group, the difference was not statistically significant (P = 0.284).Conclusions: Prophylactic treatment with azelastine hydrochloride and fluticasone propionate nasal sprays can alleviate nasal symptoms and may reduce acute asthma attacks during the pollen season.
Keywords: randomized controlled trial, prophylactic treatment, Artemisia, Pollinosis, allergic rhinitis, Asthma
Received: 12 Jan 2025; Accepted: 17 Mar 2025.
Copyright: © 2025 Cui, Gao, Bai, Zuo, Hao and GUAN. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wendong Hao, the First Affiliated Hospital of Xi’an Jiaotong University, Yulin Hospital, Yulin, China
KAI GUAN, Peking Union Medical College Hospital (CAMS), Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.