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ORIGINAL RESEARCH article
Front. Allergy
Sec. Asthma
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1557677
This article is part of the Research TopicInnovations in Allergy Diagnostics and Management: A Global PerspectiveView all 4 articles
Association Between the CALLY Index, Vitamin D, and Asthma
Provisionally accepted
Yachun Liu
Yufeng WEI*- Ganzhou People's Hospital, Ganzhou, China
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The CALLY index integrates C-reactive protein (CRP), albumin and lymphocyte counts to accurately reflect the inflammatory, nutritional and immune status of the body [1] . Recent studies have shown that the CALLY index plays a key role in a variety of diseases, especially Asthma, and is closely associated with inflammatory response, airway remodelling and immune imbalance in Asthma. Vitamin D is associated with Asthma susceptibility, severity, and control [2] , and its levels may influence inflammatory and immune markers associated with the CALLY index [3] , which may play a role in the association between the CALLY index and Asthma. The aim of this study was to investigate the association between CALLY index and Asthma and the role of Vitamin D in US adults. Patients:Using data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2010, the association between CALLY index and Asthma and the role of Vitamin D in American adults were analysed in depth. Through multiple logistic regression, subgroup analysis and other statistical means, the potential pathophysiological links between the three are revealed, providing theoretical support for the prevention and treatment of related diseases.Results:A total of 17946 subjects were included in this study, of which 2317 were diagnosed with Asthma. Fully adjusted multivariate logistic regression analysis revealed that CALLY index was significantly negatively associated with Asthma, with an odds ratio (OR) of 0.996 and a 95% confidence interval (CI) of (0.993, 0.999). Specifically, each unit increase in CALLY index was associated with a 0.996-fold reduction in Asthma risk. In addition, mediation effect analysis showed that Vitamin D partially mediated the association between CALLY index and Asthma with a mediation ratio of 3.36%.This study reveals an association between the CALLY index and reduced risk of Asthma in the US population and suggests that Vitamin D plays an incomplete mediating role. This finding provides a new theoretical basis for the diagnosis, treatment and prevention of Asthma and is expected to be a potential biomarker.
Keywords: Vitamin D, CALLY, Asthma, national Health and Nutrition Examination Survey (NHANES), Mediated effects
Received: 09 Jan 2025; Accepted: 17 Mar 2025.
Copyright: © 2025 Liu and WEI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yufeng WEI, Ganzhou People's Hospital, Ganzhou, China
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