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ORIGINAL RESEARCH article
Front. Allergy
Sec. Rhinology
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1549332
This article is part of the Research Topic Innovation in the Management of Rhinologic Disorders View all 4 articles
Tissue eosinophil level as a predictor of control, severity, and recurrence of Chronic Rhinosinusitis with Nasal Polyps
Provisionally accepted
Julissa Aida Vizcarra-Melgar 1*
Serafín Sánchez-Gómez 2,3
Nuria López-González 3
Ramon Moreno-Luna 3 Jaime González-García 3
Juan Maza-Solano 2,3- 1 Hospital of Sant Joan Despí Moisès Broggi, Sant Joan Despi, Spain
- 2 Sevilla University, Seville, Andalucia, Spain
- 3 Virgen Macarena University Hospital, Seville, Spain
The histopathologic study of nasal polyps establishes endotype features of chronic rhinosinusitis (CRS). A tissular eosinophil count greater than 10 per high power field (HPF) classifies this condition as type 2 inflammation. Blood and mucosal eosinophils are suggested as biomarkers of severity and control of CRS. Additionally, a tissular eosinophil count greater than 55 per HPF has been related to a high risk of recurrence in the Asian population. Our study aims to determine whether tissue eosinophil count is associated with the control, severity, and recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP).Vizcarra-Melgar J et al.
Keywords: chronic rhinosinusitis with nasal polyps, Eosinophilic inflammation, Tissue eosinophilia, type 2 inflammation, Disease control, biomarkers, Recurrence
Received: 20 Dec 2024; Accepted: 31 Mar 2025.
Copyright: © 2025 Vizcarra-Melgar, Sánchez-Gómez, López-González, Moreno-Luna, González-García and Maza-Solano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Julissa Aida Vizcarra-Melgar, Hospital of Sant Joan Despí Moisès Broggi, Sant Joan Despi, 08970, Spain
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