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BRIEF RESEARCH REPORT article
Front. Allergy
Sec. Allergy Diagnosis
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1543504
Development and Validation of a Delphi Consensus-Based Questionnaire for the Multidisciplinary Management of Type 2 Inflammation-Related Diseases
Provisionally accepted
Francisco Javier Ortiz De Frutos1Carolina Cisneros2
Jose Miguel Villacampa3Óscar Palomares4
Ignacio Dávila5*- 1Dermatology Department, University Hospital 12 de Octubre, Madrid, Spain, Madrid, Asturias, Spain
- 2Pneumology Department, La Princesa Hospital, Madrid, Spain, Madrid, Asturias, Spain
- 3ENT Department, Fundación Jiménez Díaz University Hospital, Madrid, Spain, Madrid, Asturias, Spain
- 4Department of Biochemistry and Molecular Biology, Faculty of Chemistry, Complutense University of Madrid, Madrid, Madrid, Spain
- 5Allergy Service, University of Salamanca, Salamanca, Spain
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Objective: This study aimed to validate a 15-item screening questionnaire for the early detection of coexisting type 2 (T2) inflammatory diseases, such as asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyps (CRSwNP), among others.The questionnaire, designed through expert consensus by a scientific committee, underwent Delphi methodology for validation. A multidisciplinary panel of 19 clinicians from different specialties reviewed the questionnaire for clinical relevance, while 39 patients from different regions of Spain evaluated its comprehensibility.The clinician panel reached a consensus on the relevance of 13 out of 15 items in the first round and agreed that a single positive response was sufficient to justify referral to the appropriate specialist. Two items were modified and validated in the second round. The patient panel unanimously agreed on the comprehensibility of the questionnaire in the first round.Linguistic variations were also ranked to ensure clarity across regions, further enhancing the validation of the tool.This validated questionnaire offers a practical tool for early detection of T2 inflammatory diseases. Its simplicity and comprehensibility, confirmed by clinicians and patients, make it suitable for use in various healthcare settings, supporting timely specialist referrals and improved patient care. Future studies will evaluate its effectiveness in real-world clinical practice.
Keywords: T2 inflammation, Management, multidisciplinary, screening, questionnaire
Received: 11 Dec 2024; Accepted: 17 Mar 2025.
Copyright: © 2025 Ortiz De Frutos, Cisneros, Villacampa, Palomares and Dávila. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ignacio Dávila, Allergy Service, University of Salamanca, Salamanca, Spain
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.