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ORIGINAL RESEARCH article

Front. Allergy
Sec. Asthma
Volume 5 - 2024 | doi: 10.3389/falgy.2024.1536168
This article is part of the Research Topic The Link Between Asthma and Obesity View all articles

Asthma and obesity increase inflammatory markers in children

Provisionally accepted
Harshita Shailesh Harshita Shailesh 1Safa Noor Safa Noor 1*Lena Hayati Lena Hayati 1*Antonisamy Belavendra Antonisamy Belavendra 1*Nicholas Van Panhuys Nicholas Van Panhuys 1Abdul Badi Abou-Samra Abdul Badi Abou-Samra 2Stefan Worgall Stefan Worgall 3Ibrahim Janahi Ibrahim Janahi 1,4*
  • 1 Sidra Medicine, Doha, Qatar
  • 2 Hamad Medical Corporation, Doha, Qatar
  • 3 Weill Cornell Medicine, Cornell University, New York, New York, United States
  • 4 Weill Cornell Medicine- Qatar, Ar-Rayyan, Qatar

The final, formatted version of the article will be published soon.

    Background: Asthma and obesity are both characterized by inflammation. However, the combined impact of these conditions on inflammatory mechanisms in children has not been studied extensively.To address this gap, we investigated the interaction effects of asthma and obesity on inflammation in children.The multiplex and singleplex assays were used to measure the levels of circulating cytokines, including IL-2, IL-5, IL-10, IL-13, IL-17A, IL-22, IL-33, IFN-γ, TNF-α, and the adipokine leptin, in plasma. The study included 97 children with normal weight and asthma (NW-A), 100 children with overweight/obesity and asthma (OO-A), 100 with overweight/obesity and no asthma (OO), and 67 normal weight children and no asthma (NW). The independent effects of asthma, obesity, and their interaction effect on these inflammatory markers were assessed using multiple regression analysis.

    Keywords: Asthma, Obesity, Inflammation, Cytokines, pediatric asthma Space Before: Auto, After: Auto, Pattern: Clear (White) Font color: Text 1, Complex Script Font: +Body (Calibri)

    Received: 28 Nov 2024; Accepted: 31 Dec 2024.

    Copyright: © 2024 Shailesh, Noor, Hayati, Belavendra, Van Panhuys, Abou-Samra, Worgall and Janahi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Safa Noor, Sidra Medicine, Doha, Qatar
    Lena Hayati, Sidra Medicine, Doha, Qatar
    Antonisamy Belavendra, Sidra Medicine, Doha, Qatar
    Ibrahim Janahi, Sidra Medicine, Doha, Qatar

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.