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BRIEF RESEARCH REPORT article

Front. Allergy
Sec. Food Allergy
Volume 5 - 2024 | doi: 10.3389/falgy.2024.1477364

Clinical and Sensitization Profile in Peach Allergy due to LTP Sensitization

Provisionally accepted

The final, formatted version of the article will be published soon.

    Background: Lipid transfer proteins (LTP) are associated with a wide range of severity of allergic reactions. However, the risk factors associated with this severity are not fully understood. Objectives:To describe the clinical characteristics of peach-allergic patients due to LTP sensitization and analyze the relationship between the severity of the reactions and patients' sensitization profiles. Methods:A retrospective study of peach-allergic patients was performed. Patients were classified into LTPmonoallergic (only peach allergy) or LTP-Syndrome (peach allergy and allergy to other plants-foods related with LTP). Symptoms with Rosaceae family and other related plant foods, skin prick tests (SPTs), and IgE values were recorded. Results: Seventy-one patients were included, 46.5% suffering from anaphylaxis, 32.3% from urticaria angioedema, and 21.2% from oral allergy syndrome. Six had monoallergy to LTP and 65 LTP syndrome. Clinical severity showed no differences according to peach SPT wheal size or Pru p 3 IgE levels. We also found no differences between the components of LTPcontaining foods analyzed, the number of LTPs recognized, and the severity of symptoms. However, anaphylaxis was more frequent in patients with concomitant allergies to ≥3 groups of plant foods.Conclusions: LTP syndrome was the most common presentation in patients with Rosaceae food allergy. The severity of the reactions was not related to peach SPT wheal size or sIgE levels to Pru p 3, but concomitant allergies to ≥3 plant food groups could be a good marker of severity.

    Keywords: lipid transfer protein, food allergy, LTP allergy, LTP syndrome, Clinical severity

    Received: 07 Aug 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Zambrano Ibarra, Rodríguez Mazariego, López Tovar, Blanco Lopez and Baeza. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Gabriela Zambrano Ibarra, Gregorio Marañón Hospital, Madrid, Spain
    Elena Rodríguez Mazariego, Gregorio Marañón Hospital, Madrid, Spain

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.