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PERSPECTIVE article

Front. Allergy
Sec. Skin Allergy
Volume 5 - 2024 | doi: 10.3389/falgy.2024.1473902
This article is part of the Research Topic Biomarkers in Allergic Eczema View all 3 articles

Thymus and Activation-regulated Chemokine (CCL17) As a Clinical Biomarker in Atopic Dermatitis: Significance and Limitations in the New Treatment Era

Provisionally accepted
葉子 片岡 葉子 片岡 *
  • Osaka Habikino Medical Center, Osaka, Japan

The final, formatted version of the article will be published soon.

    Thymus and activation-regulated chemokine (TARC; CCL17) is a T-helper-2 chemokine that reflects atopic dermatitis (AD) disease activity. Since 2008, serum TARC levels have been commercially measured in Japan, and clinical experience has shown the usefulness of TARC. The fallacy that eczema is always visible often hinders successful treatment, when there is subclinical inflammation which is inferable from the TARC level. AD treatment has entered a new era with higher therapeutic efficacy. TARC has a different meaning than it did previously, and its significance and limitations are discussed. First, a more appropriate topical therapy monitoring TARC would be useful in selecting truly necessitated patients for expensive new therapies. Dupilumab quickly lowers serum TARC before clinical improvement, and its normalization is not a criterion for dose reduction.However, in some severe cases, TARC may help determine whether to continue treatment. During treatment with JAK inhibitors, serum TARC levels are often elevated and may be abnormally high, leading to the exacerbation of dermatitis. Prurigo nodularis is divided into two types associated with

    Keywords: atopic dermatitis, monitoring biomarker, Thymus and activation-regulated chemokine, biologics, JAK inhibitors, Topical corticosteroid, 12 pt

    Received: 31 Jul 2024; Accepted: 30 Oct 2024.

    Copyright: © 2024 片岡. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: 葉子 片岡, Osaka Habikino Medical Center, Osaka, Japan

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