Skip to main content

MINI REVIEW article

Front. Allergy
Sec. Asthma
Volume 5 - 2024 | doi: 10.3389/falgy.2024.1469426
This article is part of the Research Topic Preventing Childhood Asthma: the Neglected Impact of Existing Public Health Interventions View all 5 articles

Mechanisms of microbe-mediated immune development in the context of antibiotics and asthma

Provisionally accepted
Katherine Donald Katherine Donald *
  • University of British Columbia, Vancouver, Canada

The final, formatted version of the article will be published soon.

    The gut houses 70-80% of the body's immune cells and represents the main point of contact between the immune system and the outside world. Immune maturation occurs largely after birth and is guided by the gut microbiota. In addition to the many human clinical studies that have identified relationships between gut microbiota composition and disease outcomes, experimental research has demonstrated a plethora of mechanisms by which specific microbes and microbial metabolites train the developing immune system. The healthy maturation of the gut microbiota has been wellcharacterized and discreet stages marked by changes in abundance of specific microbes have been identified. Building on Chapter 8, which discusses experimental models used to study the relationship between the gut microbiota and asthma, the present review aims to dive deeper into the specific microbes and metabolites that drive key processes in immune development. The implications of microbiota maturation patterns in the context of asthma and allergies, as well as the effects of antibiotics on microbe-immune crosstalk, will also be discussed.

    Keywords: asthma1, allergies2, microbial metabolites3, microbe-mediated immune imprinting4, antibiotics5 Font: Italic Formatted: Font: Italic Formatted: Font: Italic Formatted: Font: Italic

    Received: 23 Jul 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Donald. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Katherine Donald, University of British Columbia, Vancouver, Canada

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.