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REVIEW article
Front. Allergy
Sec. Skin Allergy
Volume 5 - 2024 |
doi: 10.3389/falgy.2024.1468983
Phototherapy as an alternative in the treatment of chronic spontaneous urticaria
Provisionally accepted- Italian Hospital of Buenos Aires, Buenos Aires, Argentina
Chronic spontaneous urticaria (CSU) is defined as the occurrence of hives, angioedema, or both, lasting for more than 6 weeks. The treatment is based on the use of antihistamines, omalizumab, and/or cyclosporine following a stepwise algorithm recommended by international guidelines with a high level of evidence. Nevertheless, management can be challenging as some patients do not respond to the suggested drugs or have difficulties accessing them for various reasons. In such cases, phototherapy has been reported as a potential treatment option.The evidence on the effectiveness of phototherapy is limited. Most studies have methodological limitations and involve small numbers of patients. A systematic review and meta-analysis of four studies in 2020 concluded that, despite the limited number of randomized controlled trials and the low level of evidence, considering overall efficacy, risk/benefit balance, and costs, narrow band ultraviolet B therapy (NB-UVB) may be a useful adjunct therapy for CSU. Other studies have suggested that the effectiveness of combined antihistamine and phototherapy appears to be more effective than antihistamine alone, although this is based on very lowquality evidence. Additionally, the risk of recurrence was lower with the combination therapy.The objective of this review was to evaluate the role of phototherapy in the treatment of CSU.While randomized studies with a larger number of participants providing a high level of evidence are still needed, we consider phototherapy to be a valuable tool in specific clinical contexts, such as a bridge to the initiation of other medications or until spontaneous remission of the condition occurs.
Keywords: Phototherapy, Urticaria, chronic spontaneous urticaria, therapy, Management
Received: 23 Jul 2024; Accepted: 28 Oct 2024.
Copyright: © 2024 Giustozzi, Torre, Ritchie and Parisi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Claudio A. Parisi, Italian Hospital of Buenos Aires, Buenos Aires, Argentina
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