Sarah A Hiles ¹ Hayley Lewthwaite ¹ Vanessa L Clark ¹ Anne E Vertigan ^2* Amber Smith ¹ Vanessa M McDonald ^1*

• ¹ The University of Newcastle, Callaghan, Australia
• ² John Hunter Hospital, Hunter New England Health, New Lambton, New South Wales, Australia

Introduction: Asthma and mental health problems co-occur at high rates. In context of a holistic approach to health, considering the extent to which social determinants relate to mental health in people with asthma helps identify health inequity and inform population-level preventative strategies. The aim of the current exploratory study was to examine how social determinants are associated with depression, anxiety and resilience in people with mild-moderate and severe asthma. Methods: A cross-sectional study of 144 adults (aged ≥18 years) with a diagnosis of asthma was conducted. Participants were classified as having mild-moderate asthma or severe asthma based on international guidelines. As part of a multidimensional assessment, participants self-reported age, sex, ethnicity, country of birth, living arrangements, employment, and postcode. They also completed validated self-report questionnaires for depression and anxiety (Hospital Anxiety and Depression Scale [HADS]), and resilience (Resilience Scale). Bayesian regression analyses were conducted to examine the extent to which social determinants were associated with depression, anxiety and resilience.Results: 74 participants had mild-moderate asthma and 70 participants had severe asthma. Participants were on average 60 years old (SD=14), 72% were female, 94% were Caucasian, 94% were Australian-born, 26% lived alone, 42% were working full-or part-time, and 83% lived in a major city of Australia. Anxiety and depression were relatively common (35% anxiety; 16% depression using HADS threshold of scores≥8). Few social determinants were associated with depression, anxiety and/or resilience. Older age was associated with greater resilience. Females had higher levels of anxiety compared to males. Compared to participants currently working full-or parttime, those who were not working or studying due to their health had worse depressive symptoms and those who were not working for other reasons such as retirement had greater resilience. Discussion: As in the general population, age, sex and employment/student status were associated with components of mental health in people with asthma. Although limited by the small sample size and low sociodemographic homogeneity, the findings of this exploratory study contribute to the large body of work fostering a holistic approach to health and striving for health equity in people with asthma, particularly those who experience mental health problems.