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ORIGINAL RESEARCH article

Front. Allergy
Sec. Asthma
Volume 5 - 2024 | doi: 10.3389/falgy.2024.1456077
This article is part of the Research Topic Preventing Childhood Asthma: the Neglected Impact of Existing Public Health Interventions View all 4 articles

Association between antibiotic usage during infancy and asthma incidence among children: a population-level ecological study in British Columbia, Canada

Provisionally accepted
Abdullah Al Mamun Abdullah Al Mamun 1*Carl Zou Carl Zou 2*Hannah Lishman Hannah Lishman 2Säde Stenlund Säde Stenlund 1,2*Max Xie Max Xie 2*Erica Chuang Erica Chuang 2David M. Patrick David M. Patrick 1,2
  • 1 University of British Columbia, Vancouver, British Columbia, Canada
  • 2 British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada

The final, formatted version of the article will be published soon.

    Background: This study follows published associations in BC to 2014BC to (updated in 2019) ) to model the predicted incidence of asthma in BC children attributable to antibiotic use within the context of reduced antibiotic use and increased breastfeeding in BC infants from 2000-2019.Methods: A population-based ecological study was conducted in BC from 2000-2019, using outpatient antibiotic prescription data from BC PharmaNet and asthma diagnoses from the Chronic Disease Registry. Breastfeeding estimates were calculated using the Canadian Community Health Survey (CCHS). Population attributable risk (PAR) was calculated using a blended relative risk (RR) of asthma in antibiotic-exposed children who were and were not breastfed. PAR was used to calculate predicted vs. actual asthma incidence in 2019. Negative binomial regression was used to estimate the association between the average antibiotic prescription rate in infants under 1 and asthma incidence in 1-4 year olds, stratified by periods

    Keywords: Asthma, antibiotics, breastfeeding, Incidence, Canada

    Received: 27 Jun 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Al Mamun, Zou, Lishman, Stenlund, Xie, Chuang and Patrick. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Abdullah Al Mamun, University of British Columbia, Vancouver, V6T 1Z2, British Columbia, Canada
    Carl Zou, British Columbia Centre for Disease Control, Vancouver, V5Z 4R4, British Columbia, Canada
    Säde Stenlund, British Columbia Centre for Disease Control, Vancouver, V5Z 4R4, British Columbia, Canada
    Max Xie, British Columbia Centre for Disease Control, Vancouver, V5Z 4R4, British Columbia, Canada

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.