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MINI REVIEW article

Front. Allergy
Sec. Skin Allergy
Volume 5 - 2024 | doi: 10.3389/falgy.2024.1448007
This article is part of the Research Topic Extracellular vesicles in allergy View all articles

Eosinophil Extracellular Vesicles and DNA Traps in Allergic Inflammation

Provisionally accepted
Tobias Weihrauch Tobias Weihrauch 1Rossana C. Melo Rossana C. Melo 2Natalie Gray Natalie Gray 1,3David Voehringer David Voehringer 4,5Peter F. Weller Peter F. Weller 6Ulrike Raap Ulrike Raap 1,7,8*
  • 1 Division of Experimental Allergy and Immunodermatology, Department of Human Medicine, Faculty of Medicine and Health Sciences, University of Oldenburg, Oldenburg, Lower Saxony, Germany
  • 2 Laboratory of Cellular Biology, Department of Biology, Institute of Biological Sciences (ICB), Federal University of Juiz de Fora, UFJF, Juiz de Fora, Brazil
  • 3 Division of Anatomy, School of Medicine and Health Sciences, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
  • 4 Department of Infection Biology, University Hospital Erlangen, Erlangen, Bavaria, Germany
  • 5 FAU Profile Center Immunomedicine (FAU I-MED), Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Bavaria, Germany
  • 6 Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States
  • 7 The Neurosensory Research Center, University of Oldenburg, Oldenburg, Germany
  • 8 University Clinic of Dermatology and Allergy, Carl von Ossietzky University Oldenburg, Oldenburg, Germany

The final, formatted version of the article will be published soon.

    Eosinophil granulocytes, a specialized subset of white blood cells, have traditionally been associated with allergic responses and parasitic infections. However, recent research has unveiled their versatile roles in immune regulation beyond these classical functions. This review highlights the emerging field of eosinophil biology, with a particular focus on their release of extracellular vesicles (EVs) and extracellular DNA traps (EETs). It further explores potential implications of eosinophil-derived EVs and EETs for immune responses during inflammatory diseases. The release of EVs/EETs from eosinophils, which also affects the eosinophils themselves, may influence both local and systemic immune reactions, affecting the pathophysiology of conditions such as airway inflammation, chronic rhinosinusitis and atopic dermatitis.

    Keywords: extracellular vesicles, eosinophil activation, sombrero vesicles, EETosis, Inflammation, eosinophilic diseases Schriftart: 14 Pt

    Received: 12 Jun 2024; Accepted: 23 Jul 2024.

    Copyright: © 2024 Weihrauch, Melo, Gray, Voehringer, Weller and Raap. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ulrike Raap, Division of Experimental Allergy and Immunodermatology, Department of Human Medicine, Faculty of Medicine and Health Sciences, University of Oldenburg, Oldenburg, 26129, Lower Saxony, Germany

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