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ORIGINAL RESEARCH article

Front. Allergy
Sec. Environmental & Occupational Determinants
Volume 5 - 2024 | doi: 10.3389/falgy.2024.1438393
This article is part of the Research Topic Allergenic bioaerosols monitoring and health impact View all articles

Fungi-sensitized Individuals Have Unique Profiles where Alt a 1 Dominates Promoting Response to Grass, Ragweed and Cat Allergens

Provisionally accepted
Viktoriia Kalyniuk Viktoriia Kalyniuk 1Victoria Rodinkova Victoria Rodinkova 2*Serhii D. Yuriev Serhii D. Yuriev 3Vitalii B. Mokin Vitalii B. Mokin 4Arsen Losenko Arsen Losenko 4Mariia Kryvopustova Mariia Kryvopustova 5Diana Zabolotna Diana Zabolotna 1Inna Gogunska Inna Gogunska 1
  • 1 Institute of Otolaryngology named after Prof. O.S. Kolomiychenko of the NAMS of Ukraine, Kyiv, Ukraine
  • 2 National Pirogov Memorial Medical University, Vinnytsya, Ukraine
  • 3 Medical Centre DIVERO, Kyiv, Ukraine
  • 4 Department of System Analysis and Information Technologies, Vinnytsia National Technical University, Vinnytsia, Ukraine
  • 5 Department of Pediatrics, Bogomolets National Medical University, Kyiv, Ukraine

The final, formatted version of the article will be published soon.

    The aim of our work was to determine comprehensively the sensitization profile of patients hypersensitive to fungal allergenic components in the Ukrainian population, identifying features of their co-sensitization to allergens of other groups and establishing potential relationships between causative allergens and their ability to provoke this hypersensitivity. A set of programs was developed using Python and R programming languages, implementing the K-means++ clustering method.Bayesian networks were constructed based on the created clusters, allowing for the assessment of the probabilistic interplay of allergen molecules in the sensitization process of patients.It was found that patients sensitive to fungi are polysensitized, with 84.77 % of them having unique allergological profiles, comprising from 2 to several dozen allergens from different groups.The immune response to Alt a 1 may act as the primary trigger for sensitization to other allergens and may contribute to a high probability of developing sensitivity to grasses (primarily to Phl p 2), ragweed extract, and the Amb a 1 pectate lyase, as well as to pectate lyase Cry j 1 and cat allergen Fel d 1.Individuals polysensitized to molecular components of fungi were often sensitive to such crossreactive molecules as lipocalins Fel d 4 and Can f 6, as well.Sensitivity to Ambrosia extract which dominated in the development of sensitization to ragweed pollen indicating the importance of different allergenic components of this plant's pollen. This hypothesis, along with the assumption that Phl p 2 may be the main trigger for sensitivity to grasses in patients with Alternaria allergy, requires further clinical investigation.

    Keywords: Alternaria, fungal sensitization, molecular diagnostics of allergy, Bayesian network analysis, K-means++ clustering

    Received: 25 May 2024; Accepted: 08 Aug 2024.

    Copyright: © 2024 Kalyniuk, Rodinkova, Yuriev, Mokin, Losenko, Kryvopustova, Zabolotna and Gogunska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Victoria Rodinkova, National Pirogov Memorial Medical University, Vinnytsya, Ukraine

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.