Original Research

Published on 26 Jun 2019

Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice

in Cellular and Molecular Mechanisms of Brain-aging

Guoqiang Wan
Lingchao Ji
Thomas Schrepfer
Sihao Gong
Guo-Peng Wang
Gabriel Corfas

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00156

5,946 views
19 citations

Original Research

Published on 19 Jun 2019

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Bérénice Hatat
Samir Yahiaoui
Cédric Lecoutey
Audrey Davis
Thomas Freret
Michel Boulouard
Sylvie Claeysen
Christophe Rochais
Patrick Dallemagne

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00148

3,652 views
22 citations

Hypothesis and Theory

Published on 13 Jun 2019

Involvement of microRNA-34a in Age-Related Susceptibility to Oxidative Stress in ARPE-19 Cells by Targeting the Silent Mating Type Information Regulation 2 Homolog 1/p66shc Pathway: Implications for Age-Related Macular Degeneration

in Cellular and Molecular Mechanisms of Brain-aging

Nianting Tong
Rong Jin
Zhanyu Zhou
Xingwei Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00137

3,732 views
18 citations

Mini Review

Published on 11 Jun 2019

Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases

in Cellular and Molecular Mechanisms of Brain-aging

Jennifer M. Hafycz
Nirinjini N. Naidoo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00140

6,505 views
17 citations

Original Research

Published on 31 May 2019

Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons

in Cellular and Molecular Mechanisms of Brain-aging

Sandra Cristina Zárate
Marianela Evelyn Traetta
Martín Gabriel Codagnone
Adriana Seilicovich
Analía Gabriela Reinés

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00123

20,825 views
56 citations

Review

Published on 24 Apr 2019

Gi/o-Protein Coupled Receptors in the Aging Brain

in Cellular and Molecular Mechanisms of Brain-aging

Patrícia G. de Oliveira
Marta L. S. Ramos
António J. Amaro
Roberto A. Dias
Sandra I. Vieira

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00089

45,188 views
64 citations

Original Research

Published on 26 Mar 2019

Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer’s Disease

in Cellular and Molecular Mechanisms of Brain-aging

Qinghua Zeng
Zhimin Long
Min Feng
Yueyang Zhao
Shifang Luo
Kejian Wang
Yingxiong Wang
Guang Yang
Guiqiong He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00062

8,329 views
49 citations

Review

Published on 19 Mar 2019

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

in Cellular and Molecular Mechanisms of Brain-aging

Isadora Matias
Juliana Morgado
Flávia Carvalho Alcantara Gomes

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00059

46,463 views
279 citations

Original Research

Published on 14 Mar 2019

Divergent Mechanisms for PPARγ Agonism in Ameliorating Aging-Related Versus Cranial Irradiation-Induced Context Discrimination Deficits

in Cellular and Molecular Mechanisms of Brain-aging

Ibdanelo Cortez
Larry Denner
Kelly T. Dineley

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00038

2,520 views
6 citations

Review

Published on 11 Mar 2019

Influence of Normal Aging on Brain Autophagy: A Complex Scenario

in Cellular and Molecular Mechanisms of Brain-aging

David A. Loeffler

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00049

11,195 views
59 citations

Original Research

Published on 28 Feb 2019

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

in Cellular and Molecular Mechanisms of Brain-aging

Emiliano Trias
Pamela R. Beilby
Mariángeles Kovacs
Sofía Ibarburu
Valentina Varela
Romina Barreto-Núñez
Samuel C. Bradford
Joseph S. Beckman
Luis Barbeito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00042

14,613 views
58 citations

Original Research

Published on 26 Feb 2019

Cre-Dependent Optogenetic Transgenic Mice Without Early Age-Related Hearing Loss

in Cellular and Molecular Mechanisms of Brain-aging

Daniel Lyngholm
Shuzo Sakata

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00029

6,114 views
15 citations

Correction

Published on 19 Feb 2019

Corrigendum: Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aß1−42, and Tau Proteins in Elderly Patients With Mild Cognitive Impairment

in Cellular and Molecular Mechanisms of Brain-aging

Emmanuelle Duron
Jean-Sébastien Vidal
Dominique Grousselle
Audrey Gabelle
Sylvain Lehmann
Florence Pasquier
Stéphanie Bombois
Luc Buée
Bernadette Allinquant
Susanna Schraen-Maschke

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00011

1,593 views
3 citations

Original Research

Published on 04 Feb 2019

Iso-α-acids, Hop-Derived Bitter Components of Beer, Attenuate Age-Related Inflammation and Cognitive Decline

in Cellular and Molecular Mechanisms of Brain-aging

Yasuhisa Ano
Rena Ohya
Keiji Kondo
Hiroyuki Nakayama

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00016

5,342 views
15 citations

Correction

Published on 30 Jan 2019

Corrigendum: Detection of Microbial 16S rRNA Gene in the Blood of Patients With Parkinson's Disease

in Cellular and Molecular Mechanisms of Brain-aging

Yiwei Qian
Xiaodong Yang
Shaoqing Xu
Chunyan Wu
Nan Qin
Sheng-Di Chen
Qin Xiao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00004

2,152 views
1 citation

Original Research

Published on 29 Jan 2019

Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease

in Cellular and Molecular Mechanisms of Brain-aging

Diogo R. Feleciano
Katrin Juenemann
Manuel Iburg
Inês C. Brás
Carina I. Holmberg
Janine Kirstein

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2019.00009

7,260 views
16 citations

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Articles

Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice

A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease

Involvement of microRNA-34a in Age-Related Susceptibility to Oxidative Stress in ARPE-19 Cells by Targeting the Silent Mating Type Information Regulation 2 Homolog 1/p66shc Pathway: Implications for Age-Related Macular Degeneration

Sleep, Aging, and Cellular Health: Aged-Related Changes in Sleep and Protein Homeostasis Converge in Neurodegenerative Diseases

Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons

Gi/o-Protein Coupled Receptors in the Aging Brain

Valproic Acid Stimulates Hippocampal Neurogenesis via Activating the Wnt/β-Catenin Signaling Pathway in the APP/PS1/Nestin-GFP Triple Transgenic Mouse Model of Alzheimer’s Disease

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

Divergent Mechanisms for PPARγ Agonism in Ameliorating Aging-Related Versus Cranial Irradiation-Induced Context Discrimination Deficits

Influence of Normal Aging on Brain Autophagy: A Complex Scenario

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

Cre-Dependent Optogenetic Transgenic Mice Without Early Age-Related Hearing Loss

Corrigendum: Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aß1−42, and Tau Proteins in Elderly Patients With Mild Cognitive Impairment

Iso-α-acids, Hop-Derived Bitter Components of Beer, Attenuate Age-Related Inflammation and Cognitive Decline

Corrigendum: Detection of Microbial 16S rRNA Gene in the Blood of Patients With Parkinson's Disease

Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease