Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Editorial

Published on 27 Mar 2025

Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Zhiquan Li
Konstantinos Palikaras
Yuan Li
Vilhelm A. Bohr

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591288

266 views

Review

Accepted on 26 Mar 2025

Phospholipids and Peroxisomes in Ferroptosis: The Therapeutic Target of Acupuncture Regulating Vascular Cognitive Impairment and Dementia

in Cellular and Molecular Mechanisms of Brain-aging

Wenyu Zhang
Xinliang Wang
Donglei Lu
Qiuxuan Wang
Xuyang Feng
Sai Qi
Zhang Xuezhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1512980

Original Research

Accepted on 25 Mar 2025

The synergistic extract of Zophobas atratus and Tenebrio molitor regulates neuroplasticity and oxidative stress in a scopolamine-induced cognitive impairment model

in Cellular and Molecular Mechanisms of Brain-aging

Ngoc Buu Tran
Haesung Lee
Myoung-Geun Ji
Long Hoang Ngo
Sook-Jeong Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566621

Review

Published on 19 Mar 2025

Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies

in Cellular and Molecular Mechanisms of Brain-aging

Yulia Komleva
Kristina Shpiliukova
Nikolai Bondar
Alla Salmina
Elena Khilazheva
Sergey Illarioshkin
Michael Piradov

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1562453

665 views

Review

Published on 12 Feb 2025

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

in Cellular and Molecular Mechanisms of Brain-aging

Mi-bo Tang
Yi-xuan Liu
Zheng-wei Hu
Hai-yang Luo
Shuo Zhang
Chang-he Shi
Yu-ming Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1454735

1,506 views

Original Research

Published on 07 Feb 2025

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

in Cellular and Molecular Mechanisms of Brain-aging

Shumin Zhao
Ranran Chen
Yi An
Yali Zhang
Cheng Ma
Ying Gao
Yanchao Lu
Fei Yang
Xue Bai
Jingjing Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522073

1,159 views

Mini Review

Published on 05 Feb 2025

A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders

in Cellular and Molecular Mechanisms of Brain-aging

Birra Taha
Robert McGovern
Cornelius Lam

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1492449

950 views

Brief Research Report

Published on 24 Jan 2025

Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging

in Cellular and Molecular Mechanisms of Brain-aging

Maggie K. Pecsok
Heather Robinson
Ally Atkins
Monica E. Calkins
Mark A. Elliott
Arianna Mordy
Jacquelyn Stifelman
Ruben C. Gur
Paul J. Moberg
Ravi Prakash Reddy Nanga

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1535158

1,040 views

Original Research

Published on 23 Jan 2025

Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain

in Cellular and Molecular Mechanisms of Brain-aging

Saeideh Aran
Mohammad Ghasem Golmohammadi
Mohsen Sagha
Kamran Ghaedi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1498308

1,029 views

Review

Published on 20 Jan 2025

The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis

in Cellular and Molecular Mechanisms of Brain-aging

Ying He
Yongqing Liu
Min Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1533963

3,502 views

Review

Published on 15 Jan 2025

The role of vitamin K2 in cognitive impairment: linking vascular health to brain health

in Cellular and Molecular Mechanisms of Brain-aging

Stefanos Roumeliotis
Ioannis Kontogiorgos
Femke de Vries
Katarzyna Maresz
Jean-François Jeanne
Konstantinos Leivaditis
Leon J. Schurgers

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1527535

2,749 views

Review

Published on 23 Dec 2024

Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease

in Cellular and Molecular Mechanisms of Brain-aging

Razan Sheta
Morgan Bérard
Dylan Musiol
Laura Martínez-Drudis
Abid Oueslati

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1464706

1,859 views

Mini Review

Published on 17 Dec 2024

Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration

in Cellular and Molecular Mechanisms of Brain-aging

Harshini Chakravarthy
Vasil Georgyev
Cole Wagen
Amir Hosseini
Joanne Matsubara

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1509434

2,095 views

Original Research

Published on 05 Dec 2024

An integrated transcriptomic analysis of brain aging and strategies for healthy aging

in Cellular and Molecular Mechanisms of Brain-aging

Haiying Liu
Xin Nie
Fengwei Wang
Dandan Chen
Zhuo Zeng
Peng Shu
Junjiu Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1450337

1,714 views

Original Research

Published on 27 Nov 2024

Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells

in Cellular and Molecular Mechanisms of Brain-aging

Helena Borland Madsen
Claudia Navarro
Emilie Gasparini
Jae-Hyeon Park
Zhiquan Li
Deborah L. Croteau
Vilhelm A. Bohr

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1503336

2,801 views

Review

Published on 08 Nov 2024

The impact of body position on neurofluid dynamics: present insights and advancements in imaging

in Cellular and Molecular Mechanisms of Brain-aging

Marco Muccio
Zhe Sun
David Chu
Brianna E. Damadian
Lawrence Minkoff
Luciano Bonanni
Yulin Ge

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1454282

1,748 views

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Articles

Editorial: Targeting the aging mitochondria: mechanisms, methods, and therapeutic strategies

Phospholipids and Peroxisomes in Ferroptosis: The Therapeutic Target of Acupuncture Regulating Vascular Cognitive Impairment and Dementia

The synergistic extract of Zophobas atratus and Tenebrio molitor regulates neuroplasticity and oxidative stress in a scopolamine-induced cognitive impairment model

Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders

Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging

Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain

The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis

The role of vitamin K2 in cognitive impairment: linking vascular health to brain health

Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease

Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration

An integrated transcriptomic analysis of brain aging and strategies for healthy aging

Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells

The impact of body position on neurofluid dynamics: present insights and advancements in imaging