Frontiers in Aging Neuroscience | Cellular and Molecular Mechanisms of Brain-aging

Review

Published on 12 Feb 2025

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

in Cellular and Molecular Mechanisms of Brain-aging

Mi-bo Tang
Yi-xuan Liu
Zheng-wei Hu
Hai-yang Luo
Shuo Zhang
Chang-he Shi
Yu-ming Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1454735

551 views

Original Research

Published on 07 Feb 2025

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

in Cellular and Molecular Mechanisms of Brain-aging

Shumin Zhao
Ranran Chen
Yi An
Yali Zhang
Cheng Ma
Ying Gao
Yanchao Lu
Fei Yang
Xue Bai
Jingjing Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1522073

581 views

Mini Review

Published on 05 Feb 2025

A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders

in Cellular and Molecular Mechanisms of Brain-aging

Birra Taha
Robert McGovern
Cornelius Lam

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1492449

614 views

Brief Research Report

Published on 24 Jan 2025

Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging

in Cellular and Molecular Mechanisms of Brain-aging

Maggie K. Pecsok
Heather Robinson
Ally Atkins
Monica E. Calkins
Mark A. Elliott
Arianna Mordy
Jacquelyn Stifelman
Ruben C. Gur
Paul J. Moberg
Ravi Prakash Reddy Nanga

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1535158

746 views

Original Research

Published on 23 Jan 2025

Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain

in Cellular and Molecular Mechanisms of Brain-aging

Saeideh Aran
Mohammad Ghasem Golmohammadi
Mohsen Sagha
Kamran Ghaedi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1498308

781 views

Review

Published on 20 Jan 2025

The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis

in Cellular and Molecular Mechanisms of Brain-aging

Ying He
Yongqing Liu
Min Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1533963

1,788 views

Review

Published on 15 Jan 2025

The role of vitamin K2 in cognitive impairment: linking vascular health to brain health

in Cellular and Molecular Mechanisms of Brain-aging

Stefanos Roumeliotis
Ioannis Kontogiorgos
Femke de Vries
Katarzyna Maresz
Jean-François Jeanne
Konstantinos Leivaditis
Leon J. Schurgers

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1527535

1,416 views

Review

Published on 23 Dec 2024

Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease

in Cellular and Molecular Mechanisms of Brain-aging

Razan Sheta
Morgan Bérard
Dylan Musiol
Laura Martínez-Drudis
Abid Oueslati

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1464706

1,402 views

Mini Review

Published on 17 Dec 2024

Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration

in Cellular and Molecular Mechanisms of Brain-aging

Harshini Chakravarthy
Vasil Georgyev
Cole Wagen
Amir Hosseini
Joanne Matsubara

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1509434

1,505 views

Original Research

Published on 05 Dec 2024

An integrated transcriptomic analysis of brain aging and strategies for healthy aging

in Cellular and Molecular Mechanisms of Brain-aging

Haiying Liu
Xin Nie
Fengwei Wang
Dandan Chen
Zhuo Zeng
Peng Shu
Junjiu Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1450337

1,489 views

Original Research

Published on 27 Nov 2024

Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells

in Cellular and Molecular Mechanisms of Brain-aging

Helena Borland Madsen
Claudia Navarro
Emilie Gasparini
Jae-Hyeon Park
Zhiquan Li
Deborah L. Croteau
Vilhelm A. Bohr

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1503336

2,263 views

Review

Published on 08 Nov 2024

The impact of body position on neurofluid dynamics: present insights and advancements in imaging

in Cellular and Molecular Mechanisms of Brain-aging

Marco Muccio
Zhe Sun
David Chu
Brianna E. Damadian
Lawrence Minkoff
Luciano Bonanni
Yulin Ge

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1454282

1,574 views

Mini Review

Published on 16 Oct 2024

The essential role of CCT2 in the regulation of aggrephagy

in Cellular and Molecular Mechanisms of Brain-aging

Jie Luo
Ze-Sen Feng
Ji-Xin Tang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1491001

1,067 views

Review

Published on 03 Oct 2024

Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders

in Cellular and Molecular Mechanisms of Brain-aging

Francisco J. Barrantes

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1476909

1,678 views

Perspective

Published on 19 Sep 2024

Rejuvenation factor PF4: a potential gatekeeper for neurodegenerative diseases

in Cellular and Molecular Mechanisms of Brain-aging

Fengju Jia
Xiaoli Shen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1482922

893 views

Review

Published on 29 Aug 2024

c-Jun N-terminal kinase signaling in aging

in Cellular and Molecular Mechanisms of Brain-aging

Yihao Li
Li You
Eugenie Nepovimova
Vojtech Adam
Zbynek Heger
Klaudia Jomova
Marian Valko
Qinghua Wu
Kamil Kuca

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2024.1453710

2,520 views

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Articles

Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis

A synthesized view of the CSF-blood barrier and its surgical implications for aging disorders

Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging

Aging restricts the initial neural patterning potential of developing neural stem and progenitor cells in the adult brain

The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis

The role of vitamin K2 in cognitive impairment: linking vascular health to brain health

Behavioral analysis of motor and non-motor impairment in rodent models of Parkinson's disease

Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration

An integrated transcriptomic analysis of brain aging and strategies for healthy aging

Urolithin A and nicotinamide riboside differentially regulate innate immune defenses and metabolism in human microglial cells

The impact of body position on neurofluid dynamics: present insights and advancements in imaging

The essential role of CCT2 in the regulation of aggrephagy

Cognitive synaptopathy: synaptic and dendritic spine dysfunction in age-related cognitive disorders

Rejuvenation factor PF4: a potential gatekeeper for neurodegenerative diseases

c-Jun N-terminal kinase signaling in aging