Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Original Research

Accepted on 18 Jul 2025

Multimodal DTI-ALPS and Hippocampal Microstructural Signatures Unveil Stage-Specific Pathways in Alzheimer's Disease Progression

in Alzheimer's Disease and Related Dementias

Peng Yu
Lu Shen
Lijun Tang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1609793

Original Research

Accepted on 18 Jul 2025

Sex Differences in the Association of Cardiometabolic Risk Scores and Blood Pressure Measurements with White Matter Hyperintensities in Diverse Older Adults -HABS-HD Running Head: Sex Differences in Blood Pressure and WMH

in Alzheimer's Disease and Related Dementias

Cellas Hayes
Raul Vintimilla
Soumilee Chaudhuri
Michelle Odden

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1607646

Original Research

Accepted on 17 Jul 2025

Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer's Disease, with hypertensive dependency

in Alzheimer's Disease and Related Dementias

Ya-Yu Wang
Man Zhang
Shu-Jian Chen
Wei Miao
Zhi-Xin Wang
Ya-Jun Zhou
Si-Qi Yu
Zhongwu Sun
Xia Zhou
Xian-Feng Yu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1630022

120 views

Review

Published on 16 Jul 2025

Elucidating molecular pathogenesis and developing targeted therapeutic interventions for cerebrovascular endothelial cell-mediated vascular dementia

in Alzheimer's Disease and Related Dementias

Yanrong Yang
Hua Chen
Qibing Liu
Yang Niu
Chunyang Mao
Rui Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1623050

397 views

Original Research

Published on 16 Jul 2025

Quantitative assessment of brain glymphatic imaging features using deep learning-based EPVS segmentation and DTI-ALPS analysis in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Fenyang Chen
Tiantian Heng
Qi Feng
Rui Hua
Jiaojiao Wu
Feng Shi
Zhengluan Liao
Keyin Qiao
Zhiliang Zhang
Jianliang Miao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1621106

433 views

Review

Published on 15 Jul 2025

Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology

in Alzheimer's Disease and Related Dementias

Amy F. T. Arnsten
Isabella Perone
Min Wang
Shengtao Yang
Stacy Uchendu
Dinara Bolat
Dibyadeep Datta

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1610350

514 views

Original Research

Published on 11 Jul 2025

Cerebellar MRI-based radiomics models for identifying mild cognitive impairment: a retrospective multicenter study in Southeast China

in Alzheimer's Disease and Related Dementias

Jianping Lu
Guoen Cai
Naian Xiao
Kunmu Zheng
Qinyong Ye
Xiaochun Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1566247

397 views

Original Research

Accepted on 08 Jul 2025

miR-423-5p and miR-92a-3p in Alzheimer's disease: relationship with pathology and cognition

in Alzheimer's Disease and Related Dementias

Sang-Won Han
Young Ho Park
Jung-Min Pyun
Paula J. Bice
SangYun Kim
Andrew J. Saykin
Kwangsik Nho

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637368

185 views

Original Research

Published on 07 Jul 2025

Quantitative analysis of targeted lipidomics in the hippocampus of APP/PS1 mice employing the UHPLC-MS/MS method

in Alzheimer's Disease and Related Dementias

Shiyu Xiao
Xuemeng Wei
Bing Han
Xiaoqian Shi
Congzhen Wei
Rumeng Liang
Jingna Sun
Zheng Zhang
Zhengang Han
Li Shen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1561831

612 views

Mini Review

Published on 04 Jul 2025

Perspectives on resting-state functional magnetic resonance imaging research in vascular dementia

in Alzheimer's Disease and Related Dementias

Jinhuan Yue
Peng Wang
Xiang-fa Guo
Zeyi Wei
Kaiting He
Nuo Li
Xiaoling Li
Qinhong Zhang
Xiaoqing Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1547965

808 views

Mini Review

Accepted on 03 Jul 2025

GLP-1R as a potential link between diabetes and Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Shujun Li
Nanqu Huang
Mei Wang
Wendi Huang
Jing-Shan Shi
Yong Luo
Juan Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1601602

354 views

Brief Research Report

Published on 03 Jul 2025

Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Neha Singh-Reilly
Ryota Satoh
Jonathan Graff-Radford
Mary M. Machulda
Val J. Lowe
Keith A. Josephs
Jennifer L. Whitwell

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1615718

643 views

Original Research

Accepted on 02 Jul 2025

Region-Informed Machine Learning Model for Choroid Plexus Segmentation in Alzheimer's Disease

in Alzheimer's Disease and Related Dementias

Liangdong Zhou
Tracy Butler
Xiuyuan Wang
Samantha A Keil
Seyed Hani Hojjati
Tsung-Wei Hu
Mélissa Savard
Firoza Z Lussier
Pedro Rosa-Neto MD PhD
Lidia Glodzik

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1613320

263 views

Original Research

Published on 02 Jul 2025

Serum uric acid to creatinine ratio in patients with early-onset post-stroke cognitive impairment: a retrospective cohort study

in Alzheimer's Disease and Related Dementias

Libin Liao
Weiquan Huang
Rongchao Ma
Wentong Hu
Hui Wu
Moxi Su
Dujuan Sha

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1580722

581 views

Original Research

Published on 02 Jul 2025

Research hotspots and frontiers of glymphatic system and Alzheimer’s disease: a bibliometrics analysis

in Alzheimer's Disease and Related Dementias

Shichao Liu
Lvping Zhuang
Xiaochun Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579373

850 views

Original Research

Published on 02 Jul 2025

Hippocampal iron patterns in aging and mild cognitive impairment

in Alzheimer's Disease and Related Dementias

Sonja M. Kagerer
Laetitia Vionnet
Jiri M. G. van Bergen
Rafael Meyer
Anton F. Gietl
Klaas P. Pruessmann
Christoph Hock
Paul G. Unschuld

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1598859

499 views