Frontiers in Aging Neuroscience | Alzheimer's Disease and Related Dementias

Review

Accepted on 22 Oct 2025

Exercise Modulation of Gut Microbiota in Alzheimer's Disease: Pathophysiological Mechanisms and Therapeutic Perspectives

in Alzheimer's Disease and Related Dementias

Si-yi Leng
Qi-Hang Yang
Yang Yuan
Bingao Chen
Hongbao Chen
Weikang Ban
Jiahao Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1677896

Editorial

Published on 22 Oct 2025

Editorial: Current chemical approaches in combating neuroinflammation in Alzheimer's disease (AD)

in Alzheimer's Disease and Related Dementias

Sayan Roy Chowdhury
Venkatesh Katari
Dwaipayan Sen
Prasenjit Mondal

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1712601

318 views

Original Research

Published on 22 Oct 2025

Baseline CSF ferritin levels were associated with trajectories of depressive symptoms among older people without dementia

in Alzheimer's Disease and Related Dementias

Qing Wang
Xinwu Ye
Yongjian Lin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1516388

220 views

Original Research

Accepted on 21 Oct 2025

An investigation on Alzheimer's disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

in Alzheimer's Disease and Related Dementias

Dongmei Luo
Tenghong Lian
Ning Wei
Peng Guo
Mingyue He
Yanan Zhang
Yue Huang
Gaifen Liu
Jinghui Li
Jing Qi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1552535

Original Research

Published on 17 Oct 2025

Elevated gonadotropins and risk of dementia in Chinese adults aged over 80: a cross-sectional study

in Alzheimer's Disease and Related Dementias

Yunxia Zhu
Youyi Tu
Chenxi Ren
Yingying Ke
Qihao Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1651723

487 views

Original Research

Published on 16 Oct 2025

LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment

in Alzheimer's Disease and Related Dementias

Lucas Gephine
Sophie Corvaisier
Benoît Bernay
Thomas Freret
Marianne Leger

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1666397

763 views

Systematic Review

Published on 15 Oct 2025

Association between periodontal disease and Alzheimer's disease: a scoping review

in Alzheimer's Disease and Related Dementias

Xiaocui Zhang
Xin Huang
Mengdie Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1588008

854 views

Original Research

Published on 10 Oct 2025

Deciphering Alzheimer’s disease transcriptomics: exploration and validation of core genes in tau and Aβ pathological models toward novel therapeutic targets

in Alzheimer's Disease and Related Dementias

Hui E. Zhang
Meng Li Xiao
Jin Jin Ji
Yu Rong Cheng
Fang Lu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1621153

832 views

Original Research

Published on 10 Oct 2025

Clinical validation of a plasma-based antibody-free LC–MS method for identifying CSF amyloid positivity in mild cognitive impairment

in Alzheimer's Disease and Related Dementias

José Antonio Allué
Leticia Sarasa
Noelia Fandos
Ricardo Gonzalo
Rubén Sabido-Vera
Jorge Loscos
Judith Romero
Adrián Sánchez
Jose Terencio
Jordi A. Matias-Guiu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1681516

993 views

Original Research

Accepted on 09 Oct 2025

Multimodal Radiomics of Cerebellar Subregions for Machine Learning-Driven Alzheimer's Disease Diagnosis

in Alzheimer's Disease and Related Dementias

Xinqing Hao
Ying Li
Xiulin Wang
Changjun Ma
Ruichen Liu
Yang Jiao
Chunbo Dong
Jing Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679788

172 views

Original Research

Published on 09 Oct 2025

Tortuous extracranial arteries contribute to white Matter hyperintensities in aging brains

in Alzheimer's Disease and Related Dementias

Zhe Sun
Chenyang Li
Arjun V. Masurkar
Marco Muccio
Thomas Wisniewski
Yulin Ge

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1641214

626 views

Review

Published on 07 Oct 2025

Kynurenine pathway: a possible new mechanism for exercise in the prevention and treatment of Alzheimer's disease

in Alzheimer's Disease and Related Dementias

Gangqiang Li
Shuang Li
Wenhui Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1617690

985 views

Original Research

Published on 06 Oct 2025

The association between chronic rhinosinusitis and the risk of dementia: a longitudinal study

in Alzheimer's Disease and Related Dementias

Xinyu Zhang
Zhongmin Yin
Jia Luo
Runsheng Yang
Weijing Wang
Dongfeng Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1609790

1,125 views

Original Research

Published on 02 Oct 2025

Predictive gene expression signatures for Alzheimer’s disease using post-mortem brain tissue

in Alzheimer's Disease and Related Dementias

Ashley H. Duche
Oliver Tan
Andrius Baskys
Rachita K. Sumbria
Moom R. Roosan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1591946

1,422 views

Original Research

Published on 30 Sep 2025

Five-year dementia prediction and decision support system based on real-world data

in Alzheimer's Disease and Related Dementias

Themis P. Exarchos
George A. Dimakopoulos
Konstantinos Lazaros
Marios Krokidis
Aristidis Vrahatis
Gerasimos Grammenos
Antigoni Avramouli
Konstantina Skolariki
Roy Adams
Vasiliki Mahairaki

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670609

1,640 views

Original Research

Published on 26 Sep 2025

EEG-based minimum spanning tree analysis reveals network disruptions in Alzheimer’s disease spectrum: an observational study

in Alzheimer's Disease and Related Dementias

Xing Ye
Yixin Yan
Yingying Wang
Jingping Shi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1604345

1,400 views