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ORIGINAL RESEARCH article

Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1507035
This article is part of the Research Topic Lifestyle and Environmental Influences on Alzheimer's Disease: Exploring the Roles of Diet, Exercise, Cognitive Reserve, Sleep, and Air Quality View all 13 articles

Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015-2020

Provisionally accepted
Miao Sun Miao Sun Shuang Bao Shuang Bao *
  • Department of Neurology,General hospital of Northern Theater Command, Shen Yang, China

The final, formatted version of the article will be published soon.

    It is crucial to identify biomarkers that influence the aging process and associated health risks, given the growing severity of the global population aging issue. The objectives of our research were to evaluate cardiac metabolic index (CMI) as a novel biomarker for identifying individuals at increased risk of accelerated biological aging and to assess its use in guiding preventive strategies for aging-related health risks.The National Health and Nutrition Examination Survey (NHANES) provided crosssectional data on participants with complete information on CMI, phenotypic age (PA), and other variables. Analyses of variance and weighted χ2 tests were conducted to assess differences between groups. The relationship between CMI and biological aging was investigated using a weighted multivariate logistic regression model, restricted cubic spline (RCS) regression analysis, subgroup analysis, and interaction testing.A positive correlation between CMI and biological aging was observed in 6,272 participants. RCS regression analysis confirmed the non-linear relationship, identifying significant inflection point at 1.10. In the crude or adjusted models, the OR (95% CI), for the highest group versus the reference were 3.608 (3.108,4.188), 3.397 (2.920,3.952), and 1.550 (1.299,1.850), respectively, when categorizing CMI into different groups. Subgroup analyses and interaction tests indicate that the association between CMI and biological aging remained consistent across different subgroups. Gender, race, education level, marital status, Poverty income ratio (PIR).An elevated CMI is linked to increased risk for biological aging. This relationship may inform more effective prevention and treatment strategies for biological aging in the future. CMI be integrated into routine health screenings or aging assessments by healthcare professionals.

    Keywords: Cardiometabolic index, biological aging, Phenotypic Age, NHANES, chronological age

    Received: 06 Oct 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Sun and Bao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shuang Bao, Department of Neurology,General hospital of Northern Theater Command, Shen Yang, China

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