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REVIEW article

Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 16 - 2024 | doi: 10.3389/fnagi.2024.1485657

Neuroimaging techniques, gene therapy, and gut microbiota: Frontier advances and integrated applications in Alzheimer's Disease research

Provisionally accepted
Haitao Wang Haitao Wang 1Ling Jiang Ling Jiang 2Rui Tang Rui Tang 2*Mingxi Tang Mingxi Tang 3*
  • 1 The school of Clinical Medical Sciences, Southwest Medical University, Luzhou, China
  • 2 Chengdu Anorectal Hospital, Chengdu, Sichuan Province, China
  • 3 Department of Pathology, Ya'an People’s Hospital, Yaan, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Alzheimer's Disease (AD) is a neurodegenerative disorder marked by cognitive decline, for which effective treatments remain elusive due to complex pathogenesis. Recent advances in neuroimaging, gene therapy, and gut microbiota research offer new insights and potential intervention strategies. Neuroimaging enables early detection and staging of AD through visualization of biomarkers, aiding diagnosis and tracking of disease progression. Gene therapy presents a promising approach for modifying AD-related genetic expressions, targeting amyloid and tau pathology, and potentially repairing neuronal damage. Furthermore, emerging evidence suggests that the gut microbiota influences AD pathology through the gut-brain axis, impacting inflammation, immune response, and amyloid metabolism. However, each of these technologies faces significant challenges, including concerns about safety, efficacy, and ethical considerations. This article reviews the applications, advantages, and limitations of neuroimaging, gene therapy, and gut microbiota research in AD, with a particular focus on their combined potential for early diagnosis, mechanistic insights, and therapeutic interventions. We propose an integrated approach that leverages these tools to provide a multidimensional framework for advancing AD diagnosis, treatment, and prevention.

    Keywords: Alzheimer's disease, neuroimaging techniques, Gene Therapy, Gut Microbiota, frontier advances, interdisciplinary research

    Received: 24 Aug 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Wang, Jiang, Tang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Rui Tang, Chengdu Anorectal Hospital, Chengdu, Sichuan Province, China
    Mingxi Tang, Department of Pathology, Ya'an People’s Hospital, Yaan, 625000, Sichuan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.