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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1483045
This article is part of the Research Topic The Role of Foods, Diet, and Dietary Patterns in the Prevention and Management of Diabesity View all 7 articles

Association of Dietary Decanoic Acid Intake with Diabetes or Prediabetes: an analysis from NHANES 2005-2016

Provisionally accepted
Huangxin Zhu Huangxin Zhu Qingan Fu Qingan Fu Ruxin Chen Ruxin Chen Linfei Luo Linfei Luo *Miao Yu Miao Yu *Yue Zhou Yue Zhou *
  • Nanchang University, Nanchang, China

The final, formatted version of the article will be published soon.

    Background: With the increasing prevalence of prediabetes and diabetes, exploring dietary factors associated with prediabetes and diabetes has become a global health research priority. This study aimed to assess the relationship between dietary decanoic acid (DDA) intake and the risk of diabetes and prediabetes.Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 included 11,477 adult participants. DDA intake was assessed through two 24-hour dietary recalls and participants were grouped according to the diagnostic criteria for diabetes and prediabetes. Multivariate regression models were applied to analyze the relationship between DDA intake and diabetes and prediabetes, with subgroup analyses conducted to explore potential interactions.Results: DDA intake was significantly negatively associated with the risk of diabetes.In the fully adjusted model, each 1 g/day increase in DDA intake was associated with a 19% reduction in the odds of developing diabetes from prediabetes (OR=0.81, 95% CI: 0.68-0.96, P=0.015) and this negative association was more pronounced in individuals with higher education level (P for interaction = 0.006). Compared with the DDA intake ≤ 0.18 g/day, DDA intake > 0.58 g/day is related to reduced risk of progression to diabetes in prediabetic patients. However, the relationship between DDA intake and the risk of prediabetes was not statistically significant in the fully adjusted model(OR=0.95, 95% CI: 0.84-1.07, P=0.404).Conclusions: This study found that higher DDA intake may be associated with lower prevalence of diabetes among prediabetic population, and high education level strengthen this relationship.

    Keywords: Decanoic acid, diabetes, prediabetes, NHANES, Dietary fatty acids

    Received: 19 Aug 2024; Accepted: 18 Dec 2024.

    Copyright: © 2024 Zhu, Fu, Chen, Luo, Yu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Linfei Luo, Nanchang University, Nanchang, China
    Miao Yu, Nanchang University, Nanchang, China
    Yue Zhou, Nanchang University, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.