Hui Han
Yong Su
Jie Yin- 1College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
- 2State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China
- 3College of Animal Science and Technology, Hunan Agricultural University, Changsha, China
Editorial on the Research Topic
Gut microbial response to host metabolic phenotypes, volume II
Numerous studies have emphasized the importance of gut microbiota in modulating various physiological functions, including metabolism, inflammation, and neural development (1–3). Gut microbiota can not only affect the digestion and absorption of nutrients but also produce numerous metabolic bioactive signaling molecules to regulate host metabolism (4–6). A comprehensive understanding of the interaction of gut microbiota and host metabolism will create opportunities for new therapeutic approaches to the treatment of metabolic disorders.
It has been well-established that the gut microbiota is sensitive to dietary components, especially carbohydrates, fats, and proteins. In this Research Topic, dietary protein (Wang, Peng et al.) and starch (Wang, Zhou et al.) have been reported to shape microbial composition. Additionally, Hou et al. thoroughly discussed the role of gut microbiota in host metabolism, including carbohydrate, lipid, amino acid, and nucleic acid metabolism. These studies systematically interrogated the impact of diets with varying protein and starch content and illustrated the complex association between diets, gut microbiota and host metabolism. Moreover, studies have also revealed the diversity and characteristics of gut microbiota along the gastrointestinal tract (GIT) by using pig as a physiological relevant model of human metabolism. For example, Song et al. found that microbial richness and diversity gradually increased from the small to large intestine. Moreover, the bacterial composition was different between the small and large intestine, which might due to differing physiological functions as required by the host. Like bacteria, gut fungi is also an important part of the intestinal microbiota that interacts with host metabolism (7). However, studies on characterizing the gut fungal diversity and composition along the whole GIT are limited. In this Research Topic, Li et al. reported that the difference in the gut fungal diversity and composition along the GIT sections was smaller than that between batches in pigs.
Alterations of gut microbiota have been implicated in the pathogenesis of metabolic disorders. In this Research Topic, Dong et al. used metagenomic and metabolic methods to investigate the changes in gut microbiota (including bacteria, bacteriophage, and archaea) in mice with obesity and atherosclerosis. Long et al. gave a comprehensive overview regarding the association between gut microbiota-derived metabolites and pathogenesis of ischemic stroke. Building on the complex association between gut microbiota and metabolic disorders, studies have aimed to evaluate the causality of gut microbiota in host metabolism by using antibiotics and fecal microbiota transplantation (FMT). However, the effectiveness and impacts of FMT on specific bacterial strains remain unclear. Tan et al. showed that an antibiotic cocktail containing vancomycin, ampicillin, neomycin, and metronidazole in drinking water effectively eliminated the microbial strains belonging to Bacteroidets, Actinobacteria, and Verrucoomicrobia, which can be restored by transplantation of microbiota from healthy control mice.
Laboratory and clinical studies have highlighted the potential to use interventions related to gut microbiota for treating metabolic disorders (8–10). For example, probiotics containing either single or multiple microorganism strains (especially strains of genera Lactobacilli and Bifidobacteria) have proven to be effective therapeutic approaches for alleviating metabolic disorders (11–13). Similarly, in this Research Topic, studies showed that some strains of Lactobacillus applied in asthma (Wang W. et al.) and obesity (Ma Y. et al.) were able to modify the gut microbial composition and exhibit beneficial effects on host. Additionally, Guo et al. found that dietary intervention with oropharyngeal probiotic ENT-K12 effectively reduced episodes of upper respiratory tract infections in children with recurrent respiratory tract infections during high peak season. Besides, dietary prebiotics have been demonstrated to alter gut microbiota and impart favorable metabolic benefits. In this respect, studies in this Research Topic reported that extracts from bearberry (Ma J. et al.), dark tea (Wang C. et al.), Artemisia argyi leaf (Wang, Ma et al.), Aurantii Fructus Immaturus (Chen et al.), and cannabis (Gong et al.) were able to positively alter gut microbiota and improve metabolism and inflammation. These studies may provide novel therapeutic strategies for treating metabolic diseases.
Overall, studies in this Research Topic promoted the understating of the role of gut microbiota in host metabolism, although the precise mechanism was not fully clear. Furthermore, data from the above mentioned studies offered microbiome-based strategies for alleviating metabolic diseases. However, additional studies are necessary to further shed light on the complex interaction between gut microbiota and host metabolism in order to find opportunities to alleviate metabolism-related diseases. Additionally, the evidence of concept generated in animal models need to be further translated to clinical setting.
Author contributions
All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.
Funding
This study was supported by grants from the National Natural Science Foundation of China (32072688, 32272891, and 31872362).
Acknowledgments
We would like to thank all authors for their papers and the reviewers for the painstaking care taken in helping improve the clarity of the manuscript.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
1. Chakaroun RM, Olsson LM, Bäckhed F. The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease. Nat Rev Cardiol. (2022). doi: 10.1038/s41569-022-00771-0. [Epub ahead of print].
2. Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, et al. Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science. (2022) 378:eabm3233. doi: 10.1126/science.abm3233
3. Dohnalová L, Lundgren P, Carty JRE, Goldstein N, Wenski SL, Nanudorn P, et al. A microbiome-dependent gut-brain pathway regulates motivation for exercise. Nature. (2022) 612:739–47. doi: 10.1038/s41586-022-05525-z
4. Cox TO, Lundgren P, Nath K, Thaiss CA. Metabolic control by the microbiome. Genome Med. (2022) 14:80. doi: 10.1186/s13073-022-01092-0
5. Han H, Jiang Y, Wang M, Melaku M, Liu L, Zhao Y, et al. Intestinal dysbiosis in nonalcoholic fatty liver disease (Nafld): focusing on the gut-liver axis. Crit Rev Food Sci Nutr. (2021) 18:1–18. doi: 10.1080/10408398.2021.1966738
6. Han H, Yi B, Zhong R, Wang M, Zhang S, Ma J, et al. From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators. Microbiome. (2021) 9:162. doi: 10.1186/s40168-021-01093-y
7. Guégan M, Martin E, Tran Van V, Fel B, Hay AE, Simon L, et al. Mosquito sex and mycobiota contribute to fructose metabolism in the Asian Tiger Mosquito Aedes Albopictus. Microbiome. (2022) 10:138. doi: 10.1186/s40168-022-01325-9
8. Liu Y, Zhong X, Lin S, Xu H, Liang X, Wang Y, et al. Limosilactobacillus reuteri and Caffeoylquinic Acid synergistically promote adipose browning and ameliorate obesity-associated disorders. Microbiome. (2022) 10:226. doi: 10.1186/s40168-022-01430-9
9. Benítez-Páez A, Hartstra AV, Nieuwdorp M, Sanz Y. Species- and strain-level assessment using rrn long-amplicons suggests donor's influence on gut microbial transference via fecal transplants in metabolic syndrome subjects. Gut Microbes. (2022) 14:2078621. doi: 10.1080/19490976.2022.2078621
10. Mocanu V, Zhang Z, Deehan EC, Kao DH, Hotte N, Karmali S, et al. Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial. Nat Med. (2021) 27:1272–9. doi: 10.1038/s41591-021-01399-2
11. Liang C, Zhou XH, Gong PM, Niu HY Lyu LZ, Wu YF, et al. Lactiplantibacillus plantarum H-87 prevents high-fat diet-induced obesity by regulating bile acid metabolism in C57bl/6j mice. Food Funct. (2021) 12:4315–24. doi: 10.1039/D1FO00260K
12. Rodrigues RR, Gurung M, Li Z, García-Jaramillo M, Greer R, Gaulke C, et al. Transkingdom interactions between lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes. Nat Commun. (2021) 12:101. doi: 10.1038/s41467-020-20313-x
Keywords: gut microbiota, microbial response, host, metabolism, phenotypes
Citation: Han H, Su Y and Yin J (2023) Editorial: Gut microbial response to host metabolic phenotypes, volume II. Front. Nutr. 10:1136510. doi: 10.3389/fnut.2023.1136510
Received: 03 January 2023; Accepted: 23 January 2023;
Published: 03 February 2023.
Edited and reviewed by: Christophe Lacroix, ETH Zürich, Switzerland
Copyright © 2023 Han, Su and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yong Su, 
eW9uZy5zdSYjeDAwMDQwO25qYXUuZWR1LmNu