Arvind Babu Rajendra Santosh*
Thaon Jones- School of Dentistry, Faculty of Medical Sciences, The University of the West Indies, Kingston, Jamaica
Traditionally, a healthy mouth is a good indicator of good general health. Poor oral hygiene reflects the health of the oral cavity and is a risk factor for overall health. Although oral diseases like dental decay and periodontitis are prevalent, awareness of oral diseases is still limited. Oral disorders include a wide range of diseases that may not be confined to the oral anatomical structures but may be manifestations of systemic diseases. Identification of the risk factors of dental and oral diseases, including socio-economic determinants, plays a major role in the type of oral health care, and in the promotion of dental health awareness. This article reviews oral diseases in the Caribbean and aims to raise awareness of this subject while suggesting a research agenda for the region.
Introduction
Oral diseases can be broadly categorized into developmental, microbial, inflammatory, cystic, neoplastic, and oral manifestations of generalized or systemic diseases. The developmental pathologies may affect the soft and hard tissues of the oral cavity. Developmental malformations are the abnormalities that result from disturbances of growth and development (1, 2). The jaw bone, palate, dentition, and salivary glands may be involved in a number of disturbances that affect the shape and form of oral structures. Developmental alterations of the teeth and other structures lead to functional disturbances (3). However, greater levels of functional and aesthetic disturbances are associated with cleft lip and cleft palate. Some of the developmental disturbances are hereditary or familial due to mutations or genetic abnormalities, whereas other developmental disturbances are caused by local abnormalities or environmental influences (4). Studies on the frequency of developmental disorders of teeth show a wide range between 1.73 and 34.28% (5, 6). WHO report on the global burden of cleft-lip and/or palate data shows that an incidence of 3.74 per 1,000 live birth in Americans, 1:700 in Europeans,.82 and 4.04 per 1,000 live birth in Asians,.6 and 2.69 per 1,000 live birth in Caucasians, and 0.18 and 1.67 per 1,000 live births in Africans (7, 8). The highest incidence is found in Americans and the lowest in Africans, with an intermediate incidence in Caucasians.
The most frequent dental problem is dental caries which is microbial in origin. Dental caries result in the demineralization of inorganic constituents, whereas organic substances experience destructive damages. Infections in enamel and dentin tissue may further progress into the pulp and periapical tissues and cause serious dental problems such as pulpal and periapical inflammation (9). Periodontal diseases are infectious and inflammatory conditions primarily involve the periodontal tissues (10). These infections may spread into the jaw bone and soft tissues in favorable circumstances (11), for example, low tissue resistance, poor immune mechanism, or malnutrition. The presence of epithelial tissue within the bone marrow of the maxillae and mandible is one of the numerous dissimilarities between the jaws and other bones of the skeleton. The source of this epithelium is both odontogenic and non-odontogenic, which predisposes the jaws to the development of cystic pathology (12).
Neoplastic diseases of the oral cavity are a broader category. Neoplastic diseases are classified as odontogenic, non-odontogenic, and of salivary gland tissue origin (13). Oral tissues can develop benign or malignant neoplasms like any other body tissue, and oral cancer is of most concern to dental surgeons. The most frequent neoplasm in the mouth is oral squamous cell carcinoma (OSCC). OSCC is the fifth most frequent cancer globally with an estimated incidence of 400,000 new cases annually (14). Benign conditions such as ameloblastoma are also a concern, as they may also cause severe destruction of the jaw bone.
Oral manifestations of systemic disease may be caused by vitamin deficiencies, blood dyscrasias, metabolic disturbances, endocrine disturbances, granulomatous diseases, dermatological and mucous membrane diseases, bone diseases, and poisoning due to metals (15). Oral health providers must maintain alertness to these manifestations as the systemic disease may first present in this form. Close consideration should therefore be given to the exact pathology of oral disorders. This includes a broad spectrum of diseases ranging from modest to severe tissue damage, which will pose management challenges. Raising the awareness of oral diseases will increase the focus on the dental needs of society. To summarize, the major risk factors for oral diseases can be broadly put into three categories: dental caries, periodontal diseases, and neoplasms of the oral cavity.
Risk Factors
Dental Caries
Initially, the factors such as diet, microbial flora, and susceptible teeth were linked to the initiation and progression of dental caries (16). However, recent concepts state that caries is a resultant of factors such as a susceptible host, cariogenic micro-organisms, suitable substrate (sucrose sugar/carbohydrate), and duration of exposure (17). The four factors in the etiology of dental caries are influenced by local and general factors. Tooth alignment, salivary rate, and oral hygiene are local risk factors. Whereas, parameters such as gender, age, ethnicity, geographic variations, and socio-cultural practices are general risk factors for caries development. Diet is the most dominant variable and risk factor in establishing the prevalence and incidence of dental caries. The evidence suggests that microbial flora have a higher risk influence in the initiation and progression of dental caries. Studies on the localization of microbial flora related to dental caries suggested Streptococcus mutans as a pioneer bacteria in dental caries pathology (17). Based on the production of bacteriocins and mutacins, Streptococcus mutans are classified into four types, namely, I, II, III, and IV. The antigenicity and virulence of Streptococcus mutans are evaluated by the serotypic classification (18). Based on the chemical constituents of the cell surface in Streptococcus mutans, strains are classified as c, e, and f serotypes (19). Streptococcus mutans adhere to host tissue, i.e., tooth surface through the enzymatic action of gluocsyltransferase (GTF) enzymes. Thus, the pathogenic nature is influenced by the enzymatic factor and thus linked with the serotype of the organism (20, 21). A study that investigated the diversity, commonality, and stability of Streptococcus mutans genotypes associated with dental caries among children, identified the high caries risk S. mutans genotypes (22). Based on the studies with Streptococcus mutans genotypes, the suggestion is that epidemiological correlation with high caries risk in the community should be researched to identify the high-risk genotypes of Streptococcus mutans in the community.
Periodontal Diseases
Periodontal disease is considered a chronic disease and frequently affects all age groups, i.e., children, adolescents, adults, and the elderly (23). The periodontal structures which support teeth are important as they hold them in their anatomical position. It is not just infection that causes periodontal morbidity but other factors have a significant role in periodontal disease initiation and progression. Risk factors have a substantial impact on the response of an individual to periodontal infection. These risk factors include age, tobacco use, smoking, alcohol consumption, brushing habits, lifestyle, genetic influences, diabetes mellitus, obesity, metabolic syndrome, osteoporosis, and vitamin deficiencies (24–26). Modification of these risk factors allows us to control periodontal diseases. Understanding risk factors and the early identification of vulnerable individuals will assist a dental surgeon in planning prevention and treatment strategies for periodontal diseases (25). Based on our understanding, some of these risk factors are independent and modifiable, such as smoking and alcohol consumption. Generating awareness about modifiable risk factors and educating the public about the other risk factors in the community may raise the importance of oral health, and the rate of tooth loss may be reduced (27). Smoking is the most well-established modifiable risk factor for periodontitis. However, evidence to support a relationship between periodontal disease and nutrition, alcohol consumption, socioeconomic status, and stress levels have not been clearly established (28).
Periodontitis has been reported to affect 11% of the global population and is listed as the sixth most frequent condition in the world (29). Globally, symptoms of periodontal disease were frequently observed in adults (30, 31). A severe form of periodontal disease, aggressive periodontitis, is noted to affect 2% of teenagers worldwide. Severe periodontitis was ranked 77th among the detailed causes of Disability Adjusted Life Years (DALYs). Severe periodontitis is mentioned as a leading cause of DALYs in 9 regions of the world, namely, Australasia, Sub-Saharan Africa East, Central, East, and Southeast Asia, and Southern, Central, Tropical, and Latin America (31). It is noteworthy to mention that data on the frequency, type, and associated risk factors of periodontal disease in the Caribbean region needs to be researched.
Oral Cancer
Tumors of the head and neck comprise an important group of neoplastic conditions of the body. The incidence of head and neck cancers is increasing in many parts of the world (32). This increase remains high despite all the advances in modern medicine. These malignancies are more prevalent in the developing world and, unfortunately, have not received satisfactory attention as have the more prevalent cancers of the developed world, like lung, breast, and colon cancer (7).
According to the World Health Organization (WHO), the most commonly diagnosed cancers in males worldwide were those of the lung, prostrate, colorectal, stomach, bladder, and oral cavity, whereas in females, it is breast, colorectal, lung, stomach, uterus, cervix, ovary, bladder, liver, and oral cavity. The data on cancer statistics suggests that oral cancer is the sixth most common cancer among men and the tenth most common cancer in women. Oral cancers are reported to be more prevalent in developing countries of the world. However, oral cancers have not received satisfactory attention as compared with other common cancers (7, 31, 33–35).
More than 95% of the carcinomas of the oral cavity are of the squamous cell type in nature. They constitute a major health problem in developing countries, representing a leading cause of death. The survival index continues to be small (50%) as compared with the progress in diagnosis and treatment of other malignant tumors (7). The risk factors include tobacco chewing, smoking, alcohol consumption, immunosuppressed condition, and diets with low levels of vitamins A and C. Inadequate consumption of vegetables and fruits may contribute to the risk of oral cancer (23, 36, 37). In the Western world, the use of tobacco and alcohol is considered to be the greatest risk factor (38). These risk factors are independent and inter-dependent. Ogden (2000) suggested that tobacco smoking is associated with 75% of overall oral cancer cases. Further, it was mentioned that tobacco smoking individuals have a 6-fold risk of developing oral cancer when compared to non-smoking individuals. The ratio was similar with persons who drink alcohol and non-drinkers. The combination of tobacco and alcohol use poses a 15-fold risk of oral cancer development in comparison with non-users (39). While tobacco and alcohol use are traditionally the greatest risk factors, other known risk factors are betel quid chewing, areca nut, narcotics, epigenetic factors, and viral infections such as Human papilloma virus (HPV), Epstein Barr virus (EBV), and Hepatitis C virus. However, certain lesions are considered to be precursor lesions to oral cancer, and these include leukoplakia, erythroplakia, actinic cheilitis, lichen planus, sideropenic dysphagia (Plummer-Vinson syndrome), submucous fibrosis, dyskeratosis congenita, and discoid lupus erythematosus (40). Recently, these lesions are termed potentially malignant disorders (41). Cancer awareness programs should be targeted at different levels of the population. One suggestion would be to target schools, individuals with occupational risks, and persons with precursor lesions to prevent the further development of precursor lesion to cancer and to prevent the occurrence of both precancer and cancer among school children individuals who have smoking or other deleterious habits.
Tropical Environment and Oral Disease
The term tropical denotes a climatic feature with which other aspects such as soil and vegetation are correlated. The tropical geographical location is that portion of the globe where the sun passes directly overhead. The tilt in the earth's axis extends between 23°-30° latitude north and south of the equator, and it covers 38% of the total land surface (42). The influencing factors in tropical countries are major climatic subdivisions, socio-economic status, environment, food, water, and nutrition. Oral diseases that can result from exposure to sunlight are pigmentation, actinic chelitis, squamous cell carcinoma, keratocanthoma, basal cell carcinoma, and malignant melanoma (42). Traditionally, cultural and religious rituals involving the teeth and oro-facial soft tissues also have an impact on the oral and para-oral structures such as mutilations of teeth and oral soft tissues, tooth crown, and soft tissues (43). The significance of oral diseases in tropical environments should be focused primarily on nature and society (cultural and religious rituals). To summarize, the tropical phenomenon does not restrict the scope of these inquiries solely to this zone. It can also be said that physical processes, human characteristics, national borders, and the distribution of oral diseases in tropical countries do not coincide with lines of latitude.
Inter-relation of Oral Disease With Systemic Health
Infectious oral diseases predispose to systemic involvement and potential complications due to the hematogenous spread which can result from focal infections (44). Common inflammatory conditions of the oral tissues such as dental caries, gingivitis, and periodontitis are usually precipitated by the formation of dental plaque (45). The dilation of pulpal and periodontal vasculature due to the sequelae of inflammation provides a greater surface area that facilitates the entry of microorganisms into the bloodstream. Often, the bacteremia is transient with the highest intensity limited to the first 30 min after a triggering episode (46). On occasions, this may lead to the seeding of the microorganisms in different target organs and result in systemic infections (46). It is a well-recognized concept that oral infections, especially periodontitis may affect systemic health and contribute to systemic disease development and progression. This includes cardiovascular disease, cavernous venous thrombosis, bacterial pneumonia, diabetes mellitus, and low birth weight (47). The focus on periodontal disease is due to the fact that the periodontium can serve as a reservoir for mediators such as cytokines and interleukins which can enter the systemic circulation and induce the disease process (48–50). Based on our understanding, a large body of literature has suggested that oral infections may contribute to poor systemic health and disease development. Among the systemic developments, endocarditis has been extensively studied. A future goal in this area is to identify the epidemiological data in cases of oral infections that resulted in systemic complications.
Prevention of Oral Diseases
Preventive oral diseases programs should be aimed at the three conventional methods, namely, primary, secondary, and tertiary (51). The preventive programs should focus on the pre-pathogenic period prior to the onset of smoking habits among early adolescents with tobacco related health hazards and social problems. Prevention strategies should also focus on the early pathogenic period with prompt referral counseling centers, whereas tertiary prevention strategies are to focus on the prevention of complicating sequelae in the disease process (51, 52). Preventive programs should be targeted at various levels to improve oral cancer awareness. School children should be educated about oral health behavior, potential damages of oral tissues, and general health due to smoking and drinking. A plan may be proposed to the school education system about oral health awareness and the impact of compromised dental and oral health may probably motivate student learning and result in positive oral behavior (53). Films about neglected oral health and its impact on general health can be shown in an educational institution to promote oral health (54). Social stigmas related to oral conditions such as cleft lip and cleft palate should be identified and special care should be provided for these students.
Global Burden of Oral Diseases
The burden of oral and dental disease is high, especially in the lower socioeconomic groups and in challenged individuals in both developing and developed nations across the globe. Pathological conditions in the oral cavity such as dental decay, periodontitis, tooth loss, trauma to tooth and jaw, oropharyngeal cancers, oral mucosal lesions due to systemic manifestations, HIV related oral manifestations, and periodontal tissue damage due to diabetes are the major oral health problems worldwide (55). Poor oral hygiene and poor health have the greatest influence on the quality of life of a person (56). The varied nature of oral disease patterns across nations needs to be identified and should be used in the planning of preventive oral health care programs. Identifying the risk factors locally will help in implanting proper preventive measures for oral health.
Dental caries is still a major health problem in most industrialized countries and it affects 60–90% of school aged children (57). Worldwide, the prevalence of dental caries among adults is high as the disease affects nearly 100% of the population in the majority of countries. The data published by WHO show high Decayed, Missing, and Filled—Tooth (DMFT) values in Latin America. In several industrialized countries, older people have often had their teeth extracted due to the disease process. The proportion of edentulous adults aged 65 years is high in Albania (69%) and in the USA (26%) (7, 57). Establishing oral health awareness and the importance of teeth may increase the demand for dental treatment.
The locations characterized by high incidence rates for oral cancer (excluding the lip) are found in South and Southeast Asia (e.g., Sri Lanka, India, Pakistan, and Taiwan), parts of Western (France) and Eastern Europe (Hungary, Slovakia, and Slovenia), parts of South America (Brazil, Uruguay), the Caribbean (Puerto Rico), and in the Pacific (Papua New Guinea and Melanesia). In the Caribbean, Puerto Rico has the highest reported incidence of oral cancer (>15 per 100,000). In terms of worldwide levels, Cuba has an intermediate incidence range of cancers of the oral cavity. A Cuban study that investigated the impact of heavy cigar smoking on the population reported a smoking incidence of 7.2 per 100,000 population. The data presented was stable for over the past decade (58).
The Economic Impact of Oral Disease
Conventionally, dental treatment is sought by persons in higher socio-economic levels, as the costs associated with treating dental and oral diseases are high. Dental Caries is recognized to be the fourth most expensive disease to treat in industrialized countries. Dental practitioners provide their treatment with or without third party payment schemes and, in most developing countries, investment in oral health care is low (59). This makes the development of preventive oral awareness and preventive care programs mandatory if we are to reduce the prevalence of oral disease. Roby et al. (60) mentioned that industrialized countries like Israel spend 12.5%, Germany 8.6%, Sweden 8%, the USA 4.2%, and the UK and Sri Lanka 3.5% of their health funds for dental care (60). Identifying the “partnership networking” for oral health care is suggested as a key to reducing the economic barrier. Partnership Networking is aimed at bringing high-level healthcare professionals through a combination of regional and international experts to collaborate with local Ministries of Health and dentists to address health care gaps and elevate preventive oral health awareness, through campaigns, and outreach health services. Finding a partnership for oral health care in terms of prevention and oral health education should be a discussion point in dental society meetings, continuing dental education programs, and conferences.
Global Oral Health Inequalities
A major global problem for oral disease care is the failure to implement preventive programs and a failure to understand the social determinants of oral disease. Gaps in knowledge, the separation of oral health from general health, and inadequate evidence-based data are known to be barriers that have led to global oral health inequalities. The International Association of Dental Research (IADR) addressed these three barriers and suggested that the critical gaps in knowledge be identified as this perhaps may bring oral health concepts into the public domain (61). Developing and implementing the partnership with cognate organizations, a knowledge base that uses a standard set of reporting criteria and includes a registry of implementation trials should assist in reducing the inequalities. Emphasis should be placed on identifying the significance of social determinants of oral health. Emphasis should also be placed on the importance of integrating research on oral health inequalities with the wider goal of reducing health inequality as a whole. Emphasis should also be placed on the importance of multi, inter, and trans-disciplinary research and translational research using inter- and multi-sectorial approaches. Disease prevention strategies should be developed based on upstream prevention. Strategies should be developed that is capable of local interpretation in a way that respects cultural sensitivities and socio-economic constraints. Local, regional, and country level systems should be developed for oral health promotion and healthcare that are appropriate and recognize resource implications. The issue of oral health inequalities should be raised in wider public debates with specific emphasis on underprivileged communities (60). Reducing the barriers and proposing research driven programs. Capacity building research strategies and standardized systems for measuring oral health should raise the level of oral health awareness in society.
Oral Disease Scenario in the Caribbean
Bönecker et al. (61) revealed that evidence of a decrease in dental caries in Latin American and Caribbean children had been noted among 5–6 and 11- to 13-year-old children. Further, they mentioned that the decrease in dental caries was less prominent in the past few years (62). A national survey in St. Vincent and the Grenadines reported a high prevalence of calculus and bleeding, especially among older children. The proportion of children with healthy periodontium ranged from 51% among 7-year old and 12% in 15 to 19 years old (62, 63). As mentioned, Puerto Rico has the highest reported incidence of oral cancer in the Caribbean and Cuba has an intermediate incidence of oral cancers (59). A database search of Caribbean studies revealed that research was focused on the Epidemiology of cariology, periodontal disease, and hygiene or home care practices. In addition, other research areas found in the database were implantology, patient education, preventive dentistry, and dental education. The research findings from Caribbean studies are summarized in Table 1.
Table 1. Published research findings from the Caribbean region.
Nutrition and Oral Disease
Nutrition significantly influences the development and progression of dental and oral tissues (101). The nutritional impact on dental and oral diseases can result from either high sugar content or malnutrition. Dental caries is the most common condition that arises due to the nutritional status of a person. However, other factors also play a role in the initiation and development of carious teeth (2, 93). Nutrition-related pathologies that affect oral tissues are dental caries, periodontal diseases, erosions, fluorosis, acute necrotizing ulcerative gingivitis (102) or periodontitis or oral manifestations of avitaminoses, and micro- or macro-mineral deficiencies. Malnutrition also influences the development and growth of the dentition (103). Dental caries results from acids synthesized by cariogenic bacteria and carbohydrate sources. Oral manifestations in Vitamin B deficiency show glossitis due to loss of papilla over the dorsum of the tongue. Atrophy of fungiform and filliform papillae is observed in folic acid deficiency (104). Vitamin C deficiency presents with bleeding and spongy appearance of the gingiva. Vitamin A and D deficiencies may present as enamel hypoplasia. Vitamin A influences the turnover rate of keratinized cells. Thus, vitamin A deficiency may affect the exfoliation of oral epithelial cells and ulcerations. Vitamin K deficiency presents with wider pre-dentin thickness over the tooth (105). Minerals such as zinc, calcium, manganese, copper, magnesium, and selenium also show oral manifestations. Burning sensations of the tongue or oral cavity are associated with zinc deficiencies (106). Calcium deficiency during the growth or eruption of teeth may result in enamel hypoplasia (107). Other micro mineral deficiencies may show oral ulcerations and impaired wound healing. Acute necrotizing ulcerative gingivitis or periodontitis are usually observed in individuals with malnutrition (102).
Future Directions
Data about the global burden of oral diseases is well-documented but finding data on the oral disease status in Caribbean populations is difficult to identify among those published documents. Epidemiological research (cross sectional and longitudinal studies) on oral diseases needs to be documented on Caribbean populations. Conducting a survey with dental surgeons about their practice and experience of dental disease in the country may generate immediate documentation about the oral disease prevalence. A special focus should be made on dental caries, periodontal diseases, fluorosis, edentulouness, and oral cancer. A survey of dental surgeons that focuses on oral cancer patients in their care, similarly, ENT practitioners and medical hospitals may also assist in generating needed data on the oral cancer burden in the Caribbean population. The survey questionnaire should also include questions on habits such as smoking, alcohol, marijuana (ganja) usage, and other relevant data. The data on habits may be useful for sub-analysis of the survey questions with the disease-like risk factors. Data from cancer registries will be helpful in analyzing the risk factors for oral cancer. The need for epidemiological and surveillance studies to determine the scope of oral health problems and their impact on future dental services needs to be stressed to oral health care workers in meetings. The National Institute of Cancer in the United States of America conducts a Surveillance, Epidemiology, and End result or “SEER” program. A proposal for SEER like programs needs to be planned in the Caribbean and by developing such programs, oral cancer data will be generated in a continuous mode. Interdisciplinary studies such as oral health in HIV/AIDS, oral health in psychiatric patients, oral health in physically compromised individuals, oral mucosal lesions in patients with dermatological diseases, and periodontal health status in Type II Diabetic patients should be carried out. Studies need to be proposed for hospital-based patients such as “oral hygiene evaluation in physically and mentally challenged individuals.” Documentation of oral findings in systemic disease may strengthen the trans or multi-disciplinary approach to oral health care. Such trans or multi-disciplinary studies should be promoted in dental clinics with the medical hospital or educational institutional setups. Creating knowledge about “the importance of the primary dentition” in schoolage children between the ages of 5–13 may reverse the trend in dental diseases in the future. In school based oral health programs, information about diet and its role in dental and oral health have to be included, and the same information should be made available to parents. Conducting surveys relating to the “knowledge about oral cancer and its awareness” in individuals in the age group of 16–25 years across these educational institutions can be planned to determine the level of “awareness.” Based on the results of these survey reports, oral health care providers may understand the level of awareness, and this will be a helpful tool in revising existing oral cancer awareness programs. A number of studies have been made on tobacco smoking or chewing and oral cancer.
Jamaica has a longstanding reputation for ganja usage. Ganja is widely used for recreational, medicinal (folk medicine), and religious purposes in Jamaica. A report by the National Commission on Ganja in Jamaica suggested that one-third of ganja users started their habit at the age of 19 or below (41). Studies need to be proposed to know the “effect on the oral mucosa from smoking ganja.” The suggestion of oral mucosal evaluation in ganja smokers is being made because it is not just the carcinogens in the tobacco or any agent that is responsible for cancer formation, but the heat generated during smoking may result in a genetic assault resulting in cancer formation. Soyibo et al. mentioned that the use of drugs is relatively common among high school students in Jamaica (108). Awareness measures, such as screening camps and health talks, need to be promoted to school children at their educational institutions. The inclusion of educational courses on general and oral health in the school education system at all levels may reinforce the benefits of good oral health. Statistics on oral and maxillofacial injuries due to road traffic accidents may be helpful in creating trauma care centers.
Research needs to be funded properly in order for proper research to be carried out. Promoting research also needs funding sources, and hence, the identification of associations or institutions that can provide research funding is essential. Whereas, local associations would be ideal, many of these have depleted resources due to the impact of the local economic climate. Thus, the next area of possible funding is from regional or international associations. Finding a regional source in such associations would greatly support and enhance research activities. Globally, major dental research projects are conducted with the grant support of the International Association of Dental Research (IADR). Recently, a proposal for new regional developments in the IADR has been approved for the Caribbean region (109). IADR collaboration in the Caribbean region may assist researchers to collaborate and develop future dental research standards in this region. This is an opportunity that Caribbean researchers must take as it will provide an additional funding branch for their Research program. Thus, a directed approach to research not only increases the statistical data about dental and oral diseases in the Caribbean population but also raises awareness among the Caribbean population.
Conclusion
Despite a large number of data available on the global burden of oral diseases, the data on the Caribbean population is less. It is important to document the prevalence of various oral diseases in the Caribbean population for making oral health care policies. The data generated may be helpful to determine the oral health care required and, thus, eventually raise the concept of awareness in oral diseases. Directing the oral health care awareness program in a specific way will reduce the burden of oral diseases in the Caribbean population.
Author Contributions
ABRS made substantial contributions to the concepts, design, and intellectual content of the study and manuscript, involved in the preparation, editing, and review of the manuscript. TJ participated in manuscript writing concept, design, intellectual content of the study literature data acquisition, manuscript writing, and manuscript review. All authors contributed to the article and approved the submitted version.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's Note
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References
1. Moog U, Felbor U, Has C, Zirn B. Disorders caused by genetic mosaicism. Deutsches Arzteblatt Int. (2020) 116:119–25. doi: 10.3238/arztebl.2020.0119
2. Bandaru BK, Thankappan P, Kumar Nandan SR, Amudala R, Annem SK, Rajendra Santosh AB. The prevalence of developmental anomalies among school children in Southern district of Andhra Pradesh, India. J Oral Maxillofac Pathol. (2019) 23:160.
3. Klein OD, Oberoi S, Huysseune A, Hovorakova M, Peterka M, Peterkova R. Developmental disorders of the dentition: an update. Am J Med Genet C Semin Med Genet. (2013) 163C:318–32. doi: 10.1002/ajmg.c.31382
4. SNB. Synopsis of Oral Pathology. Pathology of Teeth and Jaw. St. Louis, MO: Mosby Publishing Company (1973).
5. Guttal KS, Naikmasur VG, Bhargava P, Bathi RJ. Frequency of developmental dental anomalies in the Indian population. Eur J Dentistry. (2010) 4:263–9. doi: 10.1055/s-0039-1697838
6. Gupta SK, Saxena P, Jain S, Jain D. Prevalence and distribution of selected developmental dental anomalies in an Indian population. J Oral Sci. (2011) 53:231–8. doi: 10.2334/josnusd.53.231
7. Petersen PE, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C. The global burden of oral diseases and risks to oral health. Bull World Health Organiz. (2005) 83:661–9.
8. William Shaw. Global strategies to reduce the health care burden of craniofacial anomalies: report of WHO meetings on international collaborative research on craniofacial anomalies. Cleft Palate Craniofac J. (2004) 41:238–43. doi: 10.1597/03-214.1
9. Farges J-C, Alliot-Licht B, Renard E, Ducret M, Gaudin A, Smith AJ, et al. Dental pulp defence and repair mechanisms in dental caries. Med Inflamm. (2015) 2015:230251. doi: 10.1155/2015/230251
10. Collins JR, Olsen J, Cuesta A, Silva-Vetri M, Hernández M, Romanos G, et al. In vitro microbiological analysis on antibacterial, anti-inflammatory, and inhibitory action on matrix metalloproteinases-8 of commercially available chlorhexidine digluconate mouth rinses. Indian J Dental Res. (2018) 29:799–807. doi: 10.4103/ijdr.IJDR_406_17
11. Gaetti-Jardim E, Landucci LF, de Oliveira KL, Costa I, Ranieri RV, Okamoto AC, et al. Microbiota associated with infections of the Jaws. Int J Dentistry. (2012) 2012:369751. doi: 10.1155/2012/369751
12. Speight PM, Takata T. New tumour entities in the 4th edition of the world health organization classification of head and neck tumours: odontogenic and maxillofacial bone tumours. Virchows Archiv. (2018) 472:331–9. doi: 10.1007/s00428-017-2182-3
13. Rajendra Santosh AB, Bakki SR, Manthapuri S. A review of research on cytological approach in salivary gland masses. Indian J Dental Res. (2018) 29:93–106. doi: 10.4103/ijdr.IJDR_190_17
14. Yap LF, Jenei V, Robinson CM, Moutasim K, Benn TM, Threadgold SP, et al. Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation. Oncogene. (2009) 28:2524–34. doi: 10.1038/onc.2009.105
15. Rajendra Santosh AB, Boyd D, Laxminarayana KK. Clinical outline of oral diseases. Dental Clin North Am. (2020) 64:1–10. doi: 10.1016/j.cden.2019.08.001
17. Wessels MR, Benedi WJ, Jennings HJ, Michon F, DiFabio JL, Kasper DL. Isolation and characterization of type IV group B Streptococcus capsular polysaccharide. Infec Immunity. (1989) 57:1089–94. doi: 10.1128/iai.57.4.1089-1094.1989
18. Rao AP, Austin RD. Serotype specific polymerase chain reaction identifies a higher prevalence of streptococcus mutans serotype k and e in a random group of children with dental caries from the Southern region of India. Contemp Clin Dent. (2014) 5:296–301. doi: 10.4103/0976-237X.137905
19. Napimoga MH, Kamiya RU, Rosa RT, Rosa EA, Hofling JF, Mattos-Graner R, et al. Genotypic diversity and virulence traits of streptococcus mutans in caries-free and caries-active individuals. J Med Microbiol. (2004) 53(Pt 7):697–703. doi: 10.1099/jmm.0.05512-0
20. Alaluusua S, Gronroos L, Zhu X, Saarela M, Matto J, Asikainen S, et al. Production of glucosyltransferases by clinical mutans streptococcal isolates as determined by semiquantitative cross-dot assay. Arch Oral Biol. (1997) 42:417–22. doi: 10.1016/S0003-9969(97)00036-8
21. Yamashita Y, Bowen WH, Burne RA, Kuramitsu HK. Role of the streptococcus mutans gtf genes in caries induction in the specific-pathogen-free rat model. Infect Immunity. (1993) 61:3811–7. doi: 10.1128/iai.61.9.3811-3817.1993
22. Cheon K, Moser SA, Wiener HW, Whiddon J, Momeni SS, Ruby JD, et al. Characteristics of streptococcus mutans genotypes and dental caries in children. Eur J Oral Sci. (2013) 121(3 Pt 1):148–55. doi: 10.1111/eos.12044
23. Babu NC, Gomes AJ. Systemic manifestations of oral diseases. J Oral Maxillof Pathol. (2011) 15:144–7. doi: 10.4103/0973-029X.84477
24. Page RC, Beck JD. Risk assessment for periodontal diseases. Int Dental J. (1997) 47:61–87. doi: 10.1111/j.1875-595X.1997.tb00680.x
25. Genco RJ, Borgnakke WS. Risk factors for periodontal disease. Periodontology 2000. (2013) 62:59–94. doi: 10.1111/j.1600-0757.2012.00457.x
26. Santosh ABR, J RC, Jones T, Brache M, Toro M, Tumanyan S, et al. The smocar study: a caribbean-based multicenter study on the prevalence and disparities linked to smoking and gingival health. Int Quart Commun Health Educ. (2020) 40:321–30. doi: 10.1177/0272684X19895901
27. Elías-Boneta AR, Toro MJ, Rivas-Tumanyan S, Rajendra-Santosh AB, Brache M, Collins CJ. Prevalence, severity, and risk factors of gingival inflammation in caribbean adults: a multi-city, cross-sectional study. Puerto Rico Health Sci J. (2018) 37:115–23.
29. Albandar JM, Brown LJ, Loe H. Clinical features of early-onset periodontitis. J Am Dental Assoc 1939. (1997) 128:1393–9. doi: 10.14219/jada.archive.1997.0058
30. Albandar JM, Streckfus CF, Adesanya MR, Winn DM. Cigar, pipe, and cigarette smoking as risk factors for periodontal disease and tooth loss. J Periodontol. (2000) 71:1874–81. doi: 10.1902/jop.2000.71.12.1874
31. Marcenes W, Kassebaum NJ, Bernabe E, Flaxman A, Naghavi M, Lopez A, et al. Global burden of oral conditions in 1990-2010: a systematic analysis. J Dental Res. (2013) 92:592–7. doi: 10.1177/0022034513490168
32. Ramana Reddy BV, Kiran Kumar K, Rajendra Santosh AB. Benign and malignant lesions of Jaw. Dental Clin North Am. (2020) 64:39–61. doi: 10.1016/j.cden.2019.08.005
33. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. Can J Clin. (2012) 62:10–29. doi: 10.3322/caac.20138
34. Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics, 1999. Cancer J Clin. (1999) 49:8–31:1. doi: 10.3322/canjclin.49.1.8
35. Mehrotra R, Yadav S. Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations. Indian J Cancer. (2006) 43:60–6. doi: 10.4103/0019-509X.25886
36. Oyebode O, Gordon-Dseagu V, Walker A, Mindell JS. Fruit and vegetable consumption and all-cause, cancer and CVD mortality: analysis of Health Survey for England data. J Epidemiol Commun Health. (2014) 68:856–62. doi: 10.1136/jech-2013-203500
37. Grimm M, Cetindis M, Biegner T, Lehman M, Munz A, Teriete P, et al. Serum vitamin D levels of patients with oral squamous cell carcinoma (OSCC) and expression of vitamin D receptor in oral precancerous lesions and OSCC. Med Oral Patol Oral Cirugía Bucal. (2015) 20:e188–95. doi: 10.4317/medoral.20368
38. Zygogianni AG, Kyrgias G, Karakitsos P, Psyrri A, Kouvaris J, Kelekis N, et al. Oral squamous cell cancer: early detection and the role of alcohol and smoking. Head Neck Oncol. (2011) 3:2. doi: 10.1186/1758-3284-3-2
39. Ogden GR, Wight AJ. Aetiology of oral cancer: alcohol. Brit J Oral Maxillof Surg. (1998) 36:247–51. doi: 10.1016/S0266-4356(98)90707-0
40. Markopoulos AK. Current aspects on oral squamous cell carcinoma. Open Dent J. (2012) 6:126–30. doi: 10.2174/1874210601206010126
41. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. (2007) 36:575–80. doi: 10.1111/j.1600-0714.2007.00582.x
43. Chandra Shekar BR, Raja Babu P. PCBaRB. Cultural factors in health and oral health. Indian J Dental Adv. (2009) 1:24–30.
44. Shay K. Infectious complications of dental and periodontal diseases in the elderly population. Clin Infect Dis. (2002) 34:1215–23. doi: 10.1086/339865
45. Nagpal R, Yamashiro Y, Izumi Y. The two-way association of periodontal infection with systemic disorders: an overview. Med Inflamm. (2015) 2015:793898. doi: 10.1155/2015/793898
46. Parahitiyawa NB, Jin LJ, Leung WK, Yam WC, Samaranayake LP. Microbiology of odontogenic bacteremia: beyond endocarditis. Clin Microbiol Rev. (2009) 22:46–64. doi: 10.1128/CMR.00011-09
47. Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin Microbiol Rev. (2000) 13:547–58. doi: 10.1128/CMR.13.4.547
48. Balaram SB, Galgali SR, Santosh AB. Periodontal Epidemiology. Eur Dent Res Biomater J. (2020) 1:20–6. doi: 10.1055/s-0040-1701183
49. Santosh Kumar Bangalore Balaram ABRSSRG. Periodontal experimental research. Eur Dent Res Biomater J. (2020) 2020:64–71. doi: 10.1055/s-0040-1713945
50. Jain P, Hassan N, Khatoon K, Mirza MA, Naseef PP, Kuruniyan MS, et al. Periodontitis and systemic disorder-an overview of relation and novel treatment modalities. Pharmaceutics. (2021) 13:1175. doi: 10.3390/pharmaceutics13081175
51. Birch S, Bridgman C, Brocklehurst P, Ellwood R, Gomez J, Helgeson M, et al. Prevention in practice–a summary. BMC Oral Health. (2015) 15 (Suppl. 1):S12. doi: 10.1186/1472-6831-15-S1-S12
52. Harvey J, Chadi N, Canadian Paediatric Society AHC. Preventing smoking in children and adolescents: recommendations for practice and policy. Paediatr Child Health. (2016) 21:209–21. doi: 10.1093/pch/21.4.209
53. Nakre PD, Harikiran AG. Effectiveness of oral health education programs: a systematic review. J Int Soc Prev Community Dent. (2013) 3:103–15. doi: 10.4103/2231-0762.127810
54. Haque SE, Rahman M, Itsuko K, Mutahara M, Kayako S, Tsutsumi A, et al. Effect of a school-based oral health education in preventing untreated dental caries and increasing knowledge, attitude, and practices among adolescents in Bangladesh. BMC Oral Health. (2016) 16:44. doi: 10.1186/s12903-016-0202-3
55. Reddy RB, Shekar PC, Chandra KL, Aravind R. Oral lesions associated with nevirapine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: a report of 10 cases. J Oral Maxillofac Pathol. (2013) 17:431–5. doi: 10.4103/0973-029X.125214
56. Collins JR, Elías AR, Brache M, Veras K, Ogando G, Toro M, et al. Association between gingival parameters and Oral health-related quality of life in Caribbean adults: a population-based cross-sectional study. BMC Oral Health. (2019) 19:234. doi: 10.1186/s12903-019-0931-1
57. Petersen PE. [Continuous improvement of oral health in the 21st century: the approach of the WHO Global Oral Health Programme]. Chin J Stomatol. (2004) 39:441–4.
58. Warnakulas1uriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. (2009) 45:309–16. doi: 10.1016/j.oraloncology.2008.06.002
59. Widstrom E, Eaton KA. Oral healthcare systems in the extended European union. Oral Health Prev Dent. (2004) 2:155–94.
60. Roby Beaglehole HB Jon Crail and Judith Mackay. The Oral Health Atlas. Mapping a Neglected Global Health Issue. Switzerland: FDI World Dental Federation publishers (2009).
61. Sgan-Cohen HD, Evans RW, Whelton H, Villena RS, MacDougall M, Williams DM. IADR global oral health inequalities research agenda (IADR-GOHIRA(R)): a call to action. J Dental Res. (2013) 92:209–11. doi: 10.1177/0022034512475214
62. Bönecker M, Cleaton-Jones P. Trends in dental caries in Latin American and Caribbean 5-6- and 11-13-year-old children: a systematic review. Commun Dentistry Oral Epidemiol. (2003) 31:152–7. doi: 10.1034/j.1600-0528.2003.00009.x
63. Alonge OK, Narendran S. Periodontal health status of school children in St. Vinc Grena. (1999) 22:18–22.
64. Pagan-Collazo GJ, Oliva J, Cuadrado L, Rivas-Tumanyan S, Elias-Boneta AR. Prevalence of hypodontia in 10- to 14-year-olds seeking orthodontic treatment at a group of clinics in Puerto Rico. Puerto Rico Health Sci J. (2014) 33:9–13.
65. Elias-Boneta AR, Toro MJ, Noboa J, Romeu FL, Mateo LR, Ahmed R, et al. Efficacy of CPC and essential oils mouthwashes compared to a negative control mouthwash in controlling established dental plaque and gingivitis: A 6-week, randomized clinical trial. Am J Dentistry. (2015) 28 Spec No A:21a−6a.
66. Ramirez K, Garcia-Rodriguez O, Murillo-Arocho M, Fernandez-Lopez O, Elias-Boneta AR. Dentogingival complex: dimension based on biotypes. Puerto Rico Health Sci J. (2013) 32:182–6.
67. Elias-Boneta AR, Toro MJ, Mateo LR, Ahmed R, Morrison BM Jr., et al. Efficacy of two fluoride-free, alcohol-free mouthwashes containing 0.075% or 0.07% CPC in controlling established dental plaque and gingivitis over a 6-week period on adults in Puerto Rico. Am J Dentistry. (2015) 28:14a–20a.
68. Elias Boneta AR, Galan Salas RM, Mateo LR, Stewart B, Mello S, Arvanitidou LS, et al. Efficacy of a mouthwash containing 0.8% arginine, PVM/MA copolymer, pyrophosphates, and 0.05% sodium fluoride compared to a commercial mouthwash containing 2.4% potassium nitrate and 0.022% sodium fluoride and a control mouthwash containing 0.05% sodium fluoride on dentine hypersensitivity: a six-week randomized clinical study. J Dentistry. (2013) 41(Suppl. 1):S34–41. doi: 10.1016/j.jdent.2012.11.004
69. Elias Boneta AR, Ramirez K, Naboa J, Mateo LR, Stewart B, Panagokos F, et al. Efficacy in reducing dentine hypersensitivity of a regimen using a toothpaste containing 8% arginine and calcium carbonate, a mouthwash containing 0.8% arginine, pyrophosphate and PVM/MA copolymer and a toothbrush compared to potassium and negative control regimens: an eight-week randomized clinical trial. J Dentistry. (2013) 41(Suppl. 1):S42–9. doi: 10.1016/j.jdent.2012.11.011
70. Palacios C, Rivas-Tumanyan S, Morou-Bermudez E, Colon AM, Torres RY, Elias-Boneta AR. Association between type, amount, and pattern of carbohydrate consumption with dental caries in 12-year-olds in Puerto Rico. Caries Res. (2016) 50:560–70. doi: 10.1159/000450655
71. Boneta AE, Aguilar MM, Romeu FL, Stewart B, DeVizio W, Proskin HM. Comparative investigation of the efficacy of triclosan/copolymer/sodium fluoride and stannous fluoride/sodium hexametaphosphate/zinc lactate dentifrices for the control of established supragingival plaque and gingivitis in a six-month clinical study. J Clin Dentistry. (2010) 21:117–23.
72. Hernandez-Cott PL, Elias Boneta A, Stewart B, DeVizio W, Proskin HM. Clinical investigation of the efficacy of a commercial mouthrinse containing 0.05% cetylpyridinium chloride in reducing dental plaque. J Clin Dentistry. (2009) 20:39–44.
73. Elias-Boneta AR, Toro MJ, Rivas-Tumanyan S, Murillo M, Orraca L, Encarnacion A, et al. Persistent oral health disparity in 12-year-old hispanics: a cross-sectional study. BMC Oral Health. (2016) 16:10. doi: 10.1186/s12903-016-0162-7
74. Mateu FA, Boneta AE, DeVizio W, Stewart B, Proskin HM. A clinical investigation of the efficacy of two dentifrices for controlling established supragingival plaque and gingivitis. J Clin Dentistry. (2008) 19:85–94.
75. Sintes JL, Elias-Boneta A, Stewart B, Volpe AR, Lovett J. Anticaries efficacy of a sodium monofluorophosphate dentifrice containing xylitol in a dicalcium phosphate dihydrate base. A 30-month caries clinical study in Costa Rica. Am J Dentistry. (2002) 15:215–9.
76. Abreu OJ, Tatakis DN, Elias-Boneta AR, Lopez Del Valle L, Hernandez R, Pousa MS, et al. Low vitamin D status strongly associated with periodontitis in Puerto Rican adults. BMC Oral Health. (2016) 16:89. doi: 10.1186/s12903-016-0288-7
77. Elias-Boneta AR, Herrero RH, Psoter K, Toro Vizcarrondo CE, Psoter WJ. The prevalence of pit and fissure sealants among twelve year olds living in Puerto Rico during 1997. Puerto Rico Health Sci J. (2006) 25:133–6.
78. Elias-Boneta AR, Crespo Kebler K, Gierbolini CC, Toro Vizcarrondo CE, Psoter WJ. Dental caries prevalence of twelve year olds in Puerto Rico. Comm Dental Health. (2003) 20:171–6.
79. Elias-Boneta AR, Ramirez K, Rivas-Tumanyan S, Murillo M, Toro MJ. Prevalence of gingivitis and calculus in 12-year-old Puerto Ricans: a cross-sectional study. BMC Oral Health. (2018) 18:13. doi: 10.1186/s12903-017-0471-5
80. Elias-Boneta AR, Encarnacion A, Rivas-Tumanyan S, Berrios-Ouslan BC, Garcia-Godoy B, Murillo M, et al. Prevalence of gingivitis in a group of 35- to 70-year-olds residing in Puerto Rico. Puerto Rico Health Sci J. (2017) 36:140–5.
81. Nazario G, Naidu R, Elias-Boneta AR. Engaging the caribbean region for oral health. Puerto Rico Health Sci J. (2014) 33:205–6.
82. Naidu R, Nunn J, Irwin JD. The effect of motivational interviewing on oral healthcare knowledge, attitudes and behaviour of parents and caregivers of preschool children: an exploratory cluster randomised controlled study. BMC Oral Health. (2015) 15:101. doi: 10.1186/s12903-015-0068-9
83. Naidu R, Nunn J, Kelly A. Socio-behavioural factors and early childhood caries: a cross-sectional study of preschool children in central Trinidad. BMC Oral Health. (2013) 13:30. doi: 10.1186/1472-6831-13-30
84. Singh H, Maharaj RG, Naidu R. Oral health among the elderly in 7 Latin American and Caribbean cities, 1999-2000: a cross-sectional study. BMC Oral Health. (2015) 15:46. doi: 10.1186/s12903-015-0030-x
85. Naidu R, Nunn J, Forde M. Oral healthcare of preschool children in Trinidad: a qualitative study of parents and caregivers. BMC Oral Health. (2012) 12:27. doi: 10.1186/1472-6831-12-27
86. Naidu RS, Nunn JH. Prevalence of enamel developmental defects and relationship with early childhood caries in Trinidad. J Dentistry Child. (2016) 83:108–13.
87. Naidu R, Nunn J, Donnelly-Swift E. Oral health-related quality of life and early childhood caries among preschool children in Trinidad. BMC Oral Health. (2016) 16:128. doi: 10.1186/s12903-016-0324-7
88. Naidu RS, Adams JS, Simeon D, Persad S. Sources of stress and psychological disturbance among dental students in the West Indies. J Dental Educ. (2002) 66:1021–30. doi: 10.1002/j.0022-0337.2002.66.9.tb03569.x
89. Rafeek RN, Marchan SM, Naidu RS, Carrotte PV. Perceived competency at graduation among dental alumni of the University of the West Indies. J Dental Educ. (2004) 68:81–8. doi: 10.1002/j.0022-0337.2004.68.1.tb03741.x
90. Newton JT, Naidu R, Sturmey P. The acceptability of the use of sedation in the management of dental anxiety in children: views of dental students. Eur J Dental Educ. (2003) 7:72–6. doi: 10.1034/j.1600-0579.2003.00301.x
91. Naidu RS, Davis L. Parents' views on factors influencing the dental health of trinidadian pre-school children. Commun Dental Health. (2008) 25:44–9.
92. Collins JR, Richardson D, Sotero K, Mateo LR, Mauriz I. Beneficial effects of an arginine-calcium carbonate desensitizing paste for treatment of dentin hypersensitivity. Am J Dentistry. (2013) 26:63–7.
93. Abreu-Placeres N, Grau-Grullón P. Cardiology consensus for undergraduates at dental schools in the Caribbean region. Eur J Dent Educ. (2021) 25:717–32. doi: 10.1111/eje.12651
94. Collins JR, Jimenez E, Martinez C, Polanco RT, Hirata R, Mousa R, et al. Clinical and histological evaluation of socket grafting using different types of bone substitute in adult patients. Implant Dentistry. (2014) 23:489–95. doi: 10.1097/ID.0000000000000106
95. Collins JR, Sued MR, Rodriguez IJ, Berg R, Coelho PG. Evaluation of human peri-implant soft tissues around alumina-blasted/acid-etched standard and platform-switched abutments. Int J Periodont Res Dentistry. (2013) 33:e51–7. doi: 10.11607/prd.0938
96. Collins J, Carpio AM, Bobadilla M, Reyes R, Gúzman I, Martínez B, et al. Prevalence of clinical attachment loss in adolescents in Santo Domingo, Dominican Republic. J Periodontol. (2005) 76:1450–4. doi: 10.1902/jop.2005.76.9.1450
97. Collins JR, Arredondo A, Roa A, Valdez Y, Leon R, Blanc V. Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults. Clin Oral Invest. (2016) 20:349–56. doi: 10.1007/s00784-015-1516-2
98. Collins JR, Berg RW, Rodriguez M, Rodriguez I, Coelho PG, Tovar N. Evaluation of human periimplant soft tissues around nonsubmerged machined standard and platform-switched abutments. Implant Dentistry. (2015) 24:57–61. doi: 10.1097/ID.0000000000000209
99. Rajendra Santosh AB, Christian NA, Jones T, Thoms-Rodriguez CA, Condappa A, Thompson T, et al. Molecular epidemiology of human papillomavirus genotypes in oral rinses from HIV-positive and HIV-negative Jamaican patients. J Invest Clin Dentistry. (2019) 10:e12365. doi: 10.1111/jicd.12365
100. Rajendra Santosh AB, Jones T, Venugopal H, Smith K, Turpin Mair JS, Edwards M, et al. Prevalence of oral tori among medical and dental students at the University of the West Indies. Dentistry. (2016) 4:9. doi: 10.5195/D3000.2016.55
101. Scardina GA, Messina P. Good oral health and diet. J Biomed Biotechnol. (2012) 2012:720692. doi: 10.1155/2012/720692
102. Jiménez LM, Duque FL, Baer PN, Jiménez SB. Necrotizing ulcerative periodontal diseases in children and young adults in Medellín, Colombia, 1965–2000. J Int Acad Periodontol. (2005) 7:55–63.
103. Heinrich-Weltzien R, Zorn C, Monse B, Kromeyer-Hauschild K. Relationship between malnutrition and the number of permanent teeth in Filipino 10- to 13-year-olds. Biomed Res Int. (2013) 2013:205950–. doi: 10.1155/2013/205950
104. Erriu M, Pili FMG, Cadoni S, Garau V. Diagnosis of lingual atrophic conditions: associations with local and systemic factors. A descriptive review. Open Dentistry J. (2016) 10:619–35. doi: 10.2174/1874210601610010619
105. Foster BL, Nociti FH Jr., Somerman MJ. The rachitic tooth. Endocr Rev. (2014) 35:1–34. doi: 10.1210/er.2013-1009
106. Jankovskis V, Selga G. Vitamin B and zinc supplements and capsaicin oral rinse treatment options for burning mouth syndrome. Medicina. (2021) 57:391. doi: 10.3390/medicina57040391
107. Mubaraki SA. Hypoplasia resulting from nutritional deficiency: a case report. Int J Clin Pediatr Dent. (2019) 12:573–6. doi: 10.5005/jp-journals-10005-1700
108. Soyibo K, Lee MG. Use of illicit drugs among high-school students in Jamaica. Bull World Health Organiz. (1999) 77:258–62.
Keywords: oral disease, dental caries, periodontitis, oral cancer, health care, nutrition, tropical, Caribbean
Citation: Rajendra Santosh AB and Jones T (2021) Tropical Oral Disease: Analysing Barriers, Burden, Nutrition, Economic Impact, and Inequalities. Front. Nutr. 8:729234. doi: 10.3389/fnut.2021.729234
Received: 22 June 2021; Accepted: 04 October 2021;
Published: 22 November 2021.
Edited by:
Md Anwarul Azim Majumder, The University of the West Indies, Cave Hill, BarbadosReviewed by:
Faisal Hakeem, King's College London, United KingdomNneka Kate Onyejaka, University of Nigeria, Nsukka, Nigeria
Bhojraj Nandlal, JSS Dental College and Hospital, India
Copyright © 2021 Rajendra Santosh and Jones. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Arvind Babu Rajendra Santosh, arvindbabu2001@gmail.com