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MINI REVIEW article

Front. Behav. Neurosci., 30 September 2021
Sec. Emotion Regulation and Processing
This article is part of the Research Topic The Burden of Stress and Depression – New Insight Into Faster and Efficient Treatment View all 14 articles

Are Noradrenergic Transmission Reducing Drugs Antidepressants?

  • Department of Psychiatry, University of Michigan, Ann Arbor, MI, United States

Major depressive disorder (MDD) remains a significant public health problem worldwide, and revised treatment strategies are therefore urgently needed, including the creation of novel antidepressant compounds or using existing molecular entities in new ways. Etiologic theories of MDD from decades ago have suggested that synaptic deficiencies of monoaminergic neurotransmitters play a causative role in this neuropsychiatric disorder, and that boosting monoamines with drugs such as SSRIs, SNRIs, TCAs, and MAOIs has antidepressant effects and in some individuals can even induce hypomania or mania. While other factors, such as various intracellular molecular pathways and hippocampal neurogenesis, undoubtedly also play a role in MDD, monoaminergic boosting drugs nonetheless have clearly demonstrated antidepressant properties. There is also, however, a body of studies in the preclinical literature suggesting that monoaminergic transmission reducing drugs, including noradrenergic ones, also have antidepressant-like behavioral properties in rodents. Given that there is increasing evidence that the monoamines have u-shaped or Janus-faced dose-response properties, in which a mid-range value is “optimal” in a variety of behavioral and physiological processes, it is plausible that either too much or too little synaptic norepinephrine in key circuits may exacerbate MDD in some individuals. Here we briefly review rodent depression-related behavioral data, focusing on the forced swim test, from three major classes of noradrenergic transmission reducing drugs (alpha2 agonists, beta blockers, alpha1 antagonists), and find much support for the hypothesis that they have antidepressant-like properties. Whether these drugs are antidepressants in human subjects remains to be determined.

Introduction

Despite intensive efforts by commercial and academic researchers for many decades, major depressive disorder (MDD) remains a significant source of morbidity and mortality throughout the world (Chen et al., 2017; Schmaal et al., 2017; Hasin et al., 2018; Ingram et al., 2020). Many individuals who experience MDD do not respond completely, or in some cases at all, to existing pharmacological or behavioral treatment modalities, leaving a need for new approaches (Mitchell, 2004; Ruhé et al., 2006; Ulrich et al., 2020). In addition to the demand for improved psychotherapeutic treatments, the field would benefit from the creation of novel pharmacological agents or the repurposing of existing compounds that may, perhaps unexpectedly, have beneficial properties in the treatment of MDD (Ebada, 2017; Demin et al., 2019).

Following the discovery of some of today’s widely used antidepressants (MAOIs, TCAs) in the mid-20th century, monoaminergic theories on the etiology of MDD were put forth, suggesting that diminished brain levels of serotonin, norepinephrine (NE), and dopamine are a causative factor in the disorder (Schildkbaut, 1965; Coppen, 1967; Janowsky et al., 1972). In the decades since then, it has become increasingly clear that a number of intracellular molecular pathways (which undoubtedly interact with the extracellular monoamines) also play a role in MDD and the physiological and behavioral responses to antidepressant drugs (Vaidya and Duman, 2001; Tanis and Duman, 2007; Miller et al., 2009; Wohleb et al., 2016), although the continued medical use of antidepressants that boost synaptic monoamines (including SSRIs, SNRIs, NDRIs, TCAs, MAOIs) reinforces the clinical utility of this approach.

For these reasons, it may be surprising to note that in the preclinical literature there is also a significant body of studies suggesting that noradrenergic transmission reducing drugs, such as the alpha2 agonist clonidine, exhibit antidepressant-like behavioral properties under a variety of experimental conditions. This may be a surprising finding since a number of the monoaminergic theories of MDD suggest that elevated monoamines should produce mania or hypomania (Schildkbaut, 1965; Coppen, 1967; Janowsky et al., 1972), and by inference transmission reducing drugs may have mood-stabilizing properties but not necessarily be antidepressants. However, a growing body of evidence suggests that endogenous serotonin, NE, and dopamine have u-shaped or Janus-faced dose-response properties for a range of behaviors, wherein too much or too little signaling may be pathological (Baldi and Bucherelli, 2005; Arnsten, 2007; Vijayraghavan et al., 2007; Giustino et al., 2016; Giustino and Maren, 2018; Groft et al., 2019). In this scenario, perhaps a non-optimal (i.e., decreased or elevated) synaptic concentration of each monoamine may result in MDD, at least in some individuals with the disorder.

Below we briefly review rodent preclinical findings on the depression-related behavioral effects of three major classes of noradrenergic transmission reducing drugs: alpha2 agonists, beta blockers, and alpha1 antagonists. We focus on three major behavioral assays: the forced swim test (FST), the tail suspension test (TST), and the sucrose preference test. We conducted a PubMed database search using the following terms (February 7, 2021): clonidine/guanfacine/dexmedetomidine/propranolol/carvedilol/nebivolol/metoprolol/atenolol/prazosin/“beta blocker(s)”/alpha1/alpha2/beta1/beta2/beta3 +“forced swim”/“forced swimming”/“tail suspension”/“sucrose preference”/antidepressant-like/depression-like. This literature search yielded a total of 489 publications. Forty-eight were judged to be relevant articles that included data with at least one of the above types of drugs (alpha2 agonists, beta blockers, alpha1 antagonists), in mice or rats that were exposed to at least one of the above three behavioral assays (FST, TST, sucrose preference). To be included, these papers had to be published in the English language, and the 48 that met these criteria are further described in Table 1. There was no limit set on how long ago the papers were published. We did not focus on studies that investigated the interaction between natural products or compounds and these noradrenergic agents.

TABLE 1
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Table 1. Summary of antidepressant-related effects of noradrenergic transmission reducing drugs.

Alpha2 Agonists

Dating back several decades, there is a body of evidence suggesting that alpha2 adrenergic agonists such as clonidine and guanfacine, which inhibit the presynaptic release of NE and activate alpha2 receptors that are also located postsynaptically, have antidepressant-like properties in rodent models. While there are some opposing data suggesting that alpha2 antagonists can have antidepressant-like effects (Muguruza et al., 2013; Uys et al., 2017), a number of studies report that alpha2 agonists such as clonidine are therapeutic when administered acutely. A number of these studies indeed suggest that clonidine, by itself, can produce antidepressant-like effects in tests such as the FST (Malinge et al., 1988, 1989; Cervo and Samanin, 1991; Cervo et al., 1992; Asakura et al., 1993, 1994; Skrebuhhova et al., 1999; Masuda et al., 2001; O’Neill et al., 2001; Malikowska et al., 2017).

Clonidine, in many cases, when given at sub-effective doses, can also potentiate the antidepressant-like effects of a wide range of other drugs that have antidepressant properties such as SSRIs, NDRIs, TCAs, MAOIs, 5HT1A agonists, lithium, lamotrigine, and others (Malinge et al., 1988, 1989; Bourin et al., 1991, 1996; Bourin et al., 2002; Hascoät et al., 1991; Hascoet et al., 1994; Redrobe and Bourin, 1997, 1998; Skrebuhhova et al., 1999; Kaster et al., 2007; Zeidan et al., 2007; Taksande et al., 2009; Kotagale et al., 2013). In some cases these effects were shown to be counteracted by alpha2 antagonists such as idazoxan or yohimbine, suggesting clonidine achieves its antidepressant-like properties through activation of the alpha2 receptor (Malinge et al., 1988, 1989; Cervo and Samanin, 1991; Masuda et al., 2001; O’Neill et al., 2001; Zeidan et al., 2007).

In contrast to these potentially therapeutic properties of clonidine, it has also been suggested that this drug can promote depression-like behavior in rodents (Kitada et al., 1983; Parale and Kulkarni, 1986; Ferrari et al., 1991; Rénéric et al., 2002), or under some circumstances has no substantial effect either alone or when co-administered with other putative antidepressants (Kitada et al., 1983; Evangelista et al., 1987; Antkiewicz-Michaluk et al., 2017).

It has also been shown that molecular overexpression of alpha2C adrenoceptors can decrease immobility in the mouse FST (Sallinen et al., 1999), perhaps mimicking the antidepressant-like effects of alpha2 agonists such as clonidine. Antidepressant-like effects of two other alpha2 agonists, guanfacine and dexmedetomidine, have also been reported in rodent models (Stone et al., 2011; Mineur et al., 2015, 2018).

Beta Blockers

Beta blockers such as propranolol and nadolol (non-selective beta1/2 antagonists), metoprolol and atenolol (beta1), and butoxamine (beta2) can exhibit antidepressant-like activity in the FST (Chopra et al., 1988; Beĭer, 1994; Aisa et al., 2008; Park et al., 2012; Zaidi et al., 2020), including potentiation of sub-effective doses of other putative antidepressants such as baclofen (Aley and Kulkarni, 1990), or antagonizing depression-like effects of other agents (Parale et al., 1987). A mouse study of propranolol and nadolol found that whereas these two drugs did not exhibit therapeutic effects in the TST, propranolol did show an antidepressant-like decrease in TST-induced hyperthermia (Liu et al., 2003). The non-selective beta blocker nebivolol has been shown to counteract the depression-like behavioral and pathophysiological effects of the chemotherapeutic agent cisplatin (Abdelkader et al., 2017). An immunocytochemical study of propranolol showed that it could reduce the number of cells that stained for Fos-like immunoreactivity in various subcortical and cortical regions, resembling standard antidepressants such as imipramine and desipramine (Duncan et al., 1996).

In contrast to these potentially therapeutic properties of beta blockers, it has also been suggested that these drugs can promote depression-like behavior in rodents (Abel and Hannigan, 1994; Stone and Quartermain, 1999; Al-Tubuly et al., 2008) including in the presence of other putative antidepressants (Zhang et al., 2009; Gu et al., 2012), or under some circumstances, they have no substantial effect either alone or when co-administered with other putative antidepressants (Danysz et al., 1986; Evangelista et al., 1987; Finnegan et al., 1987; Teste et al., 1990; Beĭer, 1994; Detke et al., 1995; Pesarico et al., 2014; Sekio and Seki, 2015; Zaidi et al., 2020). A number of studies also suggest that the beta3 agonist amibegron (also called SR58611A) has antidepressant-like properties in rodents (Consoli et al., 2007; Overstreet et al., 2008; Stemmelin et al., 2008, 2010; Tamburella et al., 2010), and it may achieve these effects by modulating serotonergic and noradrenergic signaling that is triggered by activation of beta3 receptors (Claustre et al., 2008).

Alpha1 Antagonists

Alpha1 antagonists such as prazosin and benoxathian can also exhibit antidepressant-like activity in the FST or TST (Sekio and Seki, 2015; Kurosawa et al., 2016; Wu et al., 2017), including potentiation of other putative antidepressants such as imipramine (Al-Tubuly et al., 2008). In contrast, it has also been suggested that alpha1 antagonists can promote depression-like behavior (Stone and Quartermain, 1999; Al-Tubuly et al., 2008), including in the presence of other putative antidepressants or electroconvulsive therapy (ECT; Danysz et al., 1986; Poncelet et al., 1987; Teste et al., 1990; Kaster et al., 2007; Sugimoto et al., 2011; Gu et al., 2012; Ribeiro and Pupo, 2015). Under some circumstances they have no substantial depression-related behavioral effect either alone or when co-administered with other putative antidepressants (Evangelista et al., 1987; Malinge et al., 1988, 1989; Cervo and Samanin, 1991; Schreiber and De Vry, 1993; Detke et al., 1995; Sugimoto et al., 2011; Pesarico et al., 2014). In addition, mice expressing constitutively active mutant alpha1A (but not alpha1B) adrenoceptors exhibit antidepressant-like activity in the FST and TST, that is counteracted by prazosin (Doze et al., 2009).

Table 1 summarizes the results from, and experimental parameters used in the above rodent studies on noradrenergic transmission reducing drugs in the FST, TST, and sucrose preference test. A brief analysis of the table suggests a few prominent themes or findings: (1) clonidine is the drug with the most experimental evidence supporting an antidepressant-like role. Those data support its therapeutic-like role across a variety of both mouse and rat strains, in both the FST and TST, and an amplifying beneficial role when paired with a wide range of established antidepressants; (2) there is less support at this time of an antidepressant-like role for various beta blockers and the alpha1 antagonist prazosin, where a number of studies show depression-like effects for these drugs (although other data are supportive). These drugs appear to not have been studied as extensively in these tests as clonidine; (3) very few of the studies used female mice, which should be a priority in future studies, especially considering that the rate of MDD in women is approximately twice that in men (Baxter et al., 2014; Albert, 2015); (4) only a few of the studies used C57BL/6J mice, which are widely used in behavioral neuroscience, and could be combined with studies of additional strains of mice in further investigations; and (5) prior exposure to chronic stress, which can induce MDD in susceptible human subjects (Hosang et al., 2014; Bonde et al., 2016), was rarely used in these studies and should be further addressed with additional experiments.

Discussion

The preclinical data reviewed above address the issue of whether noradrenergic transmission reducing pharmacological agents have antidepressant-like behavioral properties in rodents. While many of these studies, perhaps most numerously and convincingly for the alpha2 agonist clonidine, suggest that these drugs have therapeutic effects, a number of the publications found no effect or depression-like effects, including for the beta blocker propranolol and the alpha1 antagonist prazosin. How do we reconcile such opposing effects across studies for these drugs? Some possibilities are that they may be due to genetic differences across strains or species of animals, varying responses to acute or chronic stress, or in some cases different behavioral tests that were used. Another explanation is that since there may be a u-shaped or Janus-faced dose-response relationship for noradrenergic signaling (Arnsten, 2007; Giustino et al., 2016; Giustino and Maren, 2018), the different drug doses used in the above studies could have opposing behavioral effects, including through interaction with divergent cortical and subcortical circuits, which may vary across species and strain. If alpha2 agonists such as clonidine and guanfacine really do have more robust antidepressant-like properties than beta blockers and alpha1 antagonists, this may relate to the more general effect of alpha2 agonists decreasing the presynaptic release of NE (Gresch et al., 1995; Van Gaalen et al., 1997), which would in principle affect signaling at all subtypes of adrenoceptors simultaneously.

A number of the studies reviewed above investigated the interaction of noradrenergic transmission reducing agents with other types of drugs. Several of these studies suggest that these noradrenergic drugs can potentiate the antidepressant-like effects of SSRIs or 5HT1A agonists (Malinge et al., 1988, 1989; Bourin et al., 1991, 1996; Hascoet et al., 1994; Redrobe and Bourin, 1997, 1998; Taksande et al., 2009), although not all studies or data were supportive (Redrobe and Bourin, 1998; Rénéric et al., 2002). Despite these discrepancies, this may be a treatment strategy that has clinical ramifications for the pharmacotherapy of MDD in human subjects. It has been previously suggested (Dremencov et al., 2007a,b; Guiard et al., 2008; Fitzgerald and Watson, 2019) that serotonin and NE may have functionally opposed properties, which is consistent with the hypothesis that noradrenergic transmission reducing drugs can amplify the effects of SSRIs under some conditions. We also suggest here, consistent with a statement in our prior publication (Polis et al., 2019), that noradrenergic transmission reducing drugs may be antidepressants in a subset of humans suffering from MDD, who would also be responsive to the rapidly acting antidepressant ketamine, and to ECT. In this scenario, noradrenergic transmission reducing agents may interact with glutamatergic signaling to chronically suppress neural hyperexcitability associated with some cases of MDD (Figure 1), and possibly have rapid therapeutic onset like ketamine (Polis et al., 2019). While the molecular mechanisms through which noradrenergic transmission reducing drugs may achieve antidepressant-like effects are not well understood at this time, one possibility is that they selectively dampen certain intracellular signaling pathways after acting upon alpha and beta-adrenergic G protein-coupled receptors. There is already evidence, for example, that NE modulates the Ras/MAPK, PI3K/Akt, JAK/STAT pathways (Muthalif et al., 1998; Yanagawa et al., 2010; Guo et al., 2013; Maity et al., 2020).

FIGURE 1
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Figure 1. Proposed therapeutic mechanisms of noradrenergic transmission reducing drugs. These pharmacological agents (alpha2 agonists, beta blockers, alpha1 antagonists) may produce antidepressant-like effects by dampening systemic inflammation, while also counteracting glutamatergically-mediated neural hyperexcitability.

One might argue that noradrenergic transmission reducing drugs are, based on monoaminergic theories of mood disorders, more likely to have mood-stabilizing than antidepressant properties. After all, beta blockers such as propranolol have historically been more associated with induction of MDD or depressive-like symptomatology (Koella, 1985; Rosen and Kostis, 1985) (but also see: Kim et al., 2019; Kessing et al., 2020), or with attenuation of hypomania or mania (Emrich et al., 1979; Nemeth and Mckenzie Chustz, 2020), where the latter property has also been attributed to clonidine (Hardy et al., 1986; Nemeth and Mckenzie Chustz, 2020). One possibility is that if these drugs really are antidepressants under some conditions, they achieve these effects in individuals who exhibit neural “decoupling” of NE with dopamine in mood-related circuits. In such an individual, elevated noradrenergic signaling may result in MDD rather than dopamine-facilitated hypomania or mania (Diehl and Gershon, 1992). Since MDD is also associated with systemic inflammation (Miller et al., 2009), noradrenergic transmission reducing agents may also produce antidepressant effects by counteracting neuroinflammation (Chen et al., 2015; Ding et al., 2019; Apple et al., 2020; Figure 1).

In conclusion, while there are conflicting data in rodents as to whether noradrenergic transmission reducing drugs have antidepressant-like properties, a number of studies reviewed above support this hypothesis, at least under some experimental conditions. At present, it is not clear whether neural noradrenergic transmission is elevated or suppressed in MDD (Waldmeier, 1981), where perhaps each state exists in different individuals. For these reasons, additional preclinical, mechanistic studies are needed, including those that induce depression-like behavior in animal models through the use of chronic mild stress. Based on the foundation of preclinical studies reviewed briefly here, further investigation of noradrenergic transmission reducing drugs in human mood disorders also appears warranted.

Author Contributions

The author alone conceived of, researched, wrote, and edited this publication.

Conflict of Interest

The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

References

Abdelkader, N. F., Saad, M. A., and Abdelsalam, R. M. (2017). Neuroprotective effect of nebivolol against cisplatin-associated depressive-like behavior in rats. J. Neurochem. 141, 449–460. doi: 10.1111/jnc.13978

PubMed Abstract | CrossRef Full Text | Google Scholar

Abel, E. L., and Hannigan, J. H. (1994). The immobility response in the forced swim test: paradoxical effect of imipramine. Eur. J. Pharmacol. 258, 261–264. doi: 10.1016/0014-2999(94)90488-x

PubMed Abstract | CrossRef Full Text | Google Scholar

Aisa, B., Tordera, R., Lasheras, B., Del Río, J., and Ramírez, M. J. (2008). Effects of maternal separation on hypothalamic-pituitary-adrenal responses, cognition and vulnerability to stress in adult female rats. Neuroscience 154, 1218–1226. doi: 10.1016/j.neuroscience.2008.05.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Albert, P. R. (2015). Why is depression more prevalent in women? J. Psychiatry Neurosci. 40, 219–221. doi: 10.1503/jpn.150205

PubMed Abstract | CrossRef Full Text | Google Scholar

Aley, K., and Kulkarni, S. (1990). Effect of baclofen, a GABAB-agonist, on forced swimming-induced immobility in mice. Arch. Int. Pharmacodyn. Ther. 307, 18–31.

PubMed Abstract | Google Scholar

Al-Tubuly, R. A., Aburawi, S. M., Alghzewi, E. A., Gorash, Z. M., and Errwami, S. (2008). The effect of sympathetic antagonists on the antidepressant action of alprazolam. Libyan J. Med. 3, 78–83. doi: 10.4176/080101

PubMed Abstract | CrossRef Full Text | Google Scholar

Antkiewicz-Michaluk, L., Romańska, I., Wąsik, A., and Michaluk, J. (2017). Antidepressant-like effect of the endogenous neuroprotective amine, 1MeTIQ in clonidine-induced depression: behavioral and neurochemical studies in rats. Neurotox. Res. 32, 94–106. doi: 10.1007/s12640-017-9715-z

PubMed Abstract | CrossRef Full Text | Google Scholar

Apple, C. G., Miller, E. S., Loftus, T. J., Kannan, K. B., Thompson, C. W., Lopez, M. C., et al. (2020). Effect of β-blockade on the expression of regulatory MicroRNA after severe trauma and chronic stress. J. Am. Coll. Surg. 230, 121–129. doi: 10.1016/j.jamcollsurg.2019.09.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Arnsten, A. F. T. (2007). Catecholamine and second messenger influences on prefrontal cortical networks of “representational knowledge”: a rational bridge between genetics and the symptoms of mental illness. Cereb. Cortex 17, i6–i15. doi: 10.1093/cercor/bhm033

PubMed Abstract | CrossRef Full Text | Google Scholar

Asakura, W., Matsumoto, K., Ohta, H., Watanabe, H., Asakura, W., Matsumoto, K., et al. (1993). Effect of α 2-adrenergic drugs on REM sleep deprivation-induced increase in swimming activity. Pharmacol. Biochem. Behav. 46, 111–115. doi: 10.1016/0091-3057(93)90325-n

PubMed Abstract | CrossRef Full Text | Google Scholar

Asakura, W., Matsumoto, K., Ohta, H., Watanabe, H., Matsumoto, K., Ohta, H., et al. (1994). Monoamine depletion attenuates the rem sleep deprivation-induced increase in clonidine response in the forced swimming test. Pharmacol. Biochem. Behav. 49, 79–84. doi: 10.1016/0091-3057(94)90459-6

PubMed Abstract | CrossRef Full Text | Google Scholar

Baldi, E., and Bucherelli, C. (2005). The inverted “u-shaped” dose-effect relationships in learning and memory: modulation of arousal and consolidation. Nonlinearity Biol. Toxicol. Med. 3, 9–21. doi: 10.2201/nonlin.003.01.002

PubMed Abstract | CrossRef Full Text | Google Scholar

Baxter, A. J., Scott, K. M., Ferrari, A. J., Norman, R. E., Vos, T., and Whiteford, H. A. (2014). Challenging the myth of an “epidemic” of common mental disorders: trends in the global prevalence of anxiety and depression between 1990 and 2010. Depress. Anxiety 31, 506–516. doi: 10.1002/da.22230

PubMed Abstract | CrossRef Full Text | Google Scholar

Beĭer, E. (1994). [A comparative evaluation of the antidepressive activity of different β-adrenoblockaders]. Eksp. Klin. Farmakol. 57, 20–21.

PubMed Abstract | Google Scholar

Bonde, J. P., Utzon-Frank, N., Bertelsen, M., Borritz, M., Eller, N. H., Nordentoft, M., et al. (2016). Risk of depressive disorder following disasters and military deployment: systematic review with meta-analysis. Br. J. Psychiatry 208, 330–336. doi: 10.1192/bjp.bp.114.157859

PubMed Abstract | CrossRef Full Text | Google Scholar

Bourin, M., Colombel, M.-C., Malinge, M., and Bradwejn, J. (1991). Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity. J. Psychiatry Neurosci. 16, 199–203.

PubMed Abstract | Google Scholar

Bourin, M., Hascoët, M., Colombel, M., Coutts, R. T., and Baker, G. B. (2002). Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice. J. Psychiatry Neurosci. 27, 178–185.

PubMed Abstract | Google Scholar

Bourin, M., Hascoet, M., Colombel, M.-C., Redrobe, J. P., and Baker, G. B. (1996). Differential effects of clonidine, lithium and quinine in the forced swimming test in mice for antidepressants: possible roles of serotoninergic systems. Eur. Neuropsychopharmacol. 6, 231–236. doi: 10.1016/0924-977x(96)00025-9

PubMed Abstract | CrossRef Full Text | Google Scholar

Cervo, L., Ross, C., and Samanin, R. (1992). The role of serotonin and dopamine in brain in the antidepressant-like effect of clonidine in the forced swimming test. Neuropharmacology 3, 331–335. doi: 10.1016/0028-3908(92)90064-v

PubMed Abstract | CrossRef Full Text | Google Scholar

Cervo, L., and Samanin, R. (1991). Clonidine causes antidepressant-like effects in rats by activating a2-adrenoceptors outside the locus coeruleus. Eur. J. Pharmacol. 193, 309–313. doi: 10.1016/0014-2999(91)90144-f

PubMed Abstract | CrossRef Full Text | Google Scholar

Chen, Y., Bennett, D., Clarke, R., Guo, Y., Yu, C., Bian, Z., et al. (2017). Patterns and correlates of major depression in Chinese adults: a cross-sectional study of 0.5 million men and women. Psychol. Med. 47, 958–970. doi: 10.1017/S0033291716002889

PubMed Abstract | CrossRef Full Text | Google Scholar

Chen, X., Zhao, C., Li, X., Wang, T., Li, Y., Cao, C., et al. (2015). Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat. Chem. Biol. 11, 19–25. doi: 10.1038/nchembio.1657

PubMed Abstract | CrossRef Full Text | Google Scholar

Chopra, K., Kunchandy, J., and Kulkarni, S. K. (1988). Benzodiazepine inverse agonist FG-7142-induced delayed behavioral depression in mice. Arch. Int. Pharmacodyn. Ther. 294, 56–63.

PubMed Abstract | Google Scholar

Claustre, Y., Leonetti, M., Santucci, V., Bougault, I., Desvignes, C., Rouquier, L., et al. (2008). Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience 156, 353–364. doi: 10.1016/j.neuroscience.2008.07.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Consoli, D., Leggio, G. M., Mazzola, C., Micale, V., and Drago, F. (2007). Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? Eur. J. Pharmacol. 573, 139–147. doi: 10.1016/j.ejphar.2007.06.048

PubMed Abstract | CrossRef Full Text | Google Scholar

Coppen, A. (1967). The biochemistry of affective disorders. Br. J. Psychiatry 113, 1237–1264. doi: 10.1192/bjp.113.504.1237

PubMed Abstract | CrossRef Full Text | Google Scholar

Danysz, W., Kostowski, W., Kozak, W., and Hauptmann, M. (1986). On the role of noradrenergic neurotransmission in the action of desipramine and amitriptyline in animal models of depression. Pol. J. Pharmacol. Pharm. 38, 285–298.

PubMed Abstract | Google Scholar

Demin, K. A., Sysoev, M., Chernysh, M. V., Savva, A. K., Koshiba, M., Wappler-Guzzetta, E. A., et al. (2019). Animal models of major depressive disorder and the implications for drug discovery and development. Expert Opin. Drug Discov. 14, 365–378. doi: 10.1080/17460441.2019.1575360

PubMed Abstract | CrossRef Full Text | Google Scholar

Detke, M. J., Wieland, S., and Lucki, I. (1995). Blockade of the antidepressant-like effects of 8.0H-DPAT, buspirone and desipramine in the rat forced swim test by 5HTIA receptor antagonists. Psychopharmacology 119, 47–54. doi: 10.1007/BF02246053

PubMed Abstract | CrossRef Full Text | Google Scholar

Diehl, D. J., and Gershon, S. (1992). The role of dopamine in mood disorders. Compr. Psychiatry 33, 115–120. doi: 10.1016/0010-440x(92)90007-d

PubMed Abstract | CrossRef Full Text | Google Scholar

Ding, M., Chen, Y., Luan, H., Zhang, X., Zhao, Z., and Wu, Y. (2019). Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes. Exp. Ther. Med. 18, 2323–2331. doi: 10.3892/etm.2019.7790

PubMed Abstract | CrossRef Full Text | Google Scholar

Doze, V. A., Handel, E. M., Jensen, K. A., Darsie, B., Luger, E. J., Haselton, J. R., et al. (2009). α1A- and α1B-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse. Brain Res. 1285, 148–157. doi: 10.1016/j.brainres.2009.06.035

PubMed Abstract | CrossRef Full Text | Google Scholar

Dremencov, E., El Mansari, M., and Blier, P. (2007a). Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons. Psychopharmacology 194, 63–72. doi: 10.1007/s00213-007-0818-8

PubMed Abstract | CrossRef Full Text | Google Scholar

Dremencov, E., El Mansari, M., and Blier, P. (2007b). Noradrenergic augmentation of escitalopram response by risperidone: electrophysiologic studies in the rat brain. Biol. Psychiatry 61, 671–678. doi: 10.1016/j.biopsych.2006.05.015

PubMed Abstract | CrossRef Full Text | Google Scholar

Duncan, G., Knapp, D., Johnson, K., and Breese, G. (1996). Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity. J. Pharmacol. Exp. Ther. 277, 1076–1089.

PubMed Abstract | Google Scholar

Ebada, M. E. (2017). Drug repurposing may generate novel approaches to treating depression. J. Pharm. Pharmacol. 69, 1428–1436. doi: 10.1111/jphp.12815

PubMed Abstract | CrossRef Full Text | Google Scholar

Emrich, H. M., von Zerssen, D., Möller, H. J., Kissling, W., Cording, C., Schietsch, H. J., et al. (1979). Action of propranolol in mania: comparison of effects of the d- and the l-stereoisomer. Pharmakopsychiatr. Neuropsychopharmakol. 12, 295–304. doi: 10.1055/s-0028-1094624

PubMed Abstract | CrossRef Full Text | Google Scholar

Evangelista, S., Borsini, F., and Meli, A. (1987). Evidence that muscimol acts in the forced swimming test by activating the rat dopaminergic system. Life Sci. 41, 2679–2684. doi: 10.1016/0024-3205(87)90283-9

PubMed Abstract | CrossRef Full Text | Google Scholar

Ferrari, F., Cassinadri, M., Tartoni, P. L., and Tampieri, A. (1991). Effects of B-HT 920 in the tail-suspension test. Pharmacol. Res. 24, 75–81. doi: 10.1016/1043-6618(91)90067-8

PubMed Abstract | CrossRef Full Text | Google Scholar

Finnegan, K., Terwillger, M. M., Berger, P. A., Holhster, L. E., and Csernansky, J. G. (1987). A comparison of the neurochemical and behavioral effects of clenbuterol and desipramine.. Eur. J. Pharmacol. 134, 131–136. doi: 10.1016/0014-2999(87)90158-0

PubMed Abstract | CrossRef Full Text | Google Scholar

Fitzgerald, P. J., and Watson, B. O. (2019). in vivo electrophysiological recordings of the effects of antidepressant drugs. Exp. Brain Res. 237, 1593–1614. doi: 10.1007/s00221-019-05556-5

PubMed Abstract | CrossRef Full Text | Google Scholar

Giustino, T. F., Fitzgerald, P. J., and Maren, S. (2016). Revisiting propranolol and PTSD: memory erasure or extinction enhancement? Neurobiol. Learn. Mem. 130, 26–33. doi: 10.1016/j.nlm.2016.01.009

PubMed Abstract | CrossRef Full Text | Google Scholar

Giustino, T. F., and Maren, S. (2018). Noradrenergic modulation of fear conditioning and extinction. Front. Behav. Neurosci. 12:43. doi: 10.3389/fnbeh.2018.00043

PubMed Abstract | CrossRef Full Text | Google Scholar

Gresch, P. J., Sved, F., Zigroond, J., and Finlay, J. M. (1995). Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex. J. Neurochem. 65, 111–116. doi: 10.1046/j.1471-4159.1995.65010111.x

PubMed Abstract | CrossRef Full Text | Google Scholar

Groft, M. L., Normann, M. C., Nicklas, P. R., Jagielo-Miller, J. E., and McLaughlin, P. J. (2019). Biphasic effects of 5-HT1A agonism on impulsive responding are dissociable from effects on anxiety in the variable consecutive number task. Naunyn Schmiedebergs Arch. Pharmacol. 392, 1455–1464. doi: 10.1007/s00210-019-01684-5

PubMed Abstract | CrossRef Full Text | Google Scholar

Gu, L., Liu, Y.-J., Wang, Y.-B., and Yi, L. T. (2012). Role for monoaminergic systems in the antidepressant-like effect of ethanol extracts from Hemerocallis citrina. J. Ethnopharmacol. 139, 780–787. doi: 10.1016/j.jep.2011.11.059

PubMed Abstract | CrossRef Full Text | Google Scholar

Guiard, B. P., El Mansari, M., Merali, Z., and Blier, P. (2008). Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions. Int. J. Neuropsychopharmacol. 11, 625–639. doi: 10.1017/S1461145707008383

PubMed Abstract | CrossRef Full Text | Google Scholar

Guo, K., Ma, Q., Li, J., Wang, Z., Shan, T., Li, W., et al. (2013). Interaction of the sympathetic nerve with pancreatic cancer cells promotes perineural invasion through the activation of STAT3 signaling. Mol. Cancer Ther. 12, 264–273. doi: 10.1158/1535-7163.MCT-12-0809

PubMed Abstract | CrossRef Full Text | Google Scholar

Hardy, M.-C., Lecrubier, Y., and Widlocher, D. (1986). Efficacy of clonidine in 24 patients with acute mania. Am. J. Psychiatry 143, 1450–1453. doi: 10.1176/ajp.143.11.1450

PubMed Abstract | CrossRef Full Text | Google Scholar

Hascoät, M., Bourin, M., and Bradwejn, J. (1991). Behavioral models in mice. implication of the α noradrenergic system. Prog. Neuropsychopharmacol. Biol. Psychiatry 15, 825–840. doi: 10.1016/0278-5846(91)90011-o

PubMed Abstract | CrossRef Full Text | Google Scholar

Hascoet, M., Bourin, M., and Khimake, S. (1994). Additive effect of lithium and clonidine with 5-HT1A agonists in the forced swimming test. Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 381–396. doi: 10.1016/0278-5846(94)90070-1

PubMed Abstract | CrossRef Full Text | Google Scholar

Hasin, D. S., Sarvet, A. L., Meyers, J. L., Saha, T. D., Ruan, W. J., Stohl, M., et al. (2018). Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States. JAMA Psychiatry 75, 336–346. doi: 10.1001/jamapsychiatry.2017.4602

PubMed Abstract | CrossRef Full Text | Google Scholar

Hosang, G. M., Shiles, C., Tansey, K. E., McGuffin, P., and Uher, R. (2014). Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. BMC Med. 12:7. doi: 10.1186/1741-7015-12-7

PubMed Abstract | CrossRef Full Text | Google Scholar

Ingram, W. M., Baker, A. M., Bauer, C. R., Brown, J. P., Goes, F. S., Larson, S., et al. (2020). Defining major depressive disorder cohorts using the EHR: multiple phenotypes based on ICD-9 codes and medication orders. Neurol. Psychiatry Brain Res. 36, 18–26. doi: 10.1016/j.npbr.2020.02.002

PubMed Abstract | CrossRef Full Text | Google Scholar

Janowsky, D. S., El-Yousef, M. K., Davis, J. M., and Sekerke, H. J. (1972). A cholinergic-adrenergic hypothesis of mania and depression. Lancet 2, 632–635. doi: 10.1016/s0140-6736(72)93021-8

PubMed Abstract | CrossRef Full Text | Google Scholar

Kaster, M. P., Raupp, I., Binfaré, R. W., Andreatini, R., and Rodrigues, A. L. S. (2007). Antidepressant-like effect of lamotrigine in the mouse forced swimming test: evidence for the involvement of the noradrenergic system. Eur. J. Pharmacol. 565, 119–124. doi: 10.1016/j.ejphar.2007.03.003

PubMed Abstract | CrossRef Full Text | Google Scholar

Kessing, L. V., Rytgaard, H. C., Ekstrøm, C. T., Torp-Pedersen, C., Berk, M., and Gerds, T. A. (2020). Antihypertensive drugs and risk of depression: a nationwide population-based study. Hypertension 76, 1263–1279. doi: 10.1161/HYPERTENSIONAHA.120.15605

PubMed Abstract | CrossRef Full Text | Google Scholar

Kim, C., Duan, L., Phan, D. Q., and Lee, M. S. (2019). Frequency of utilization of β blockers in patients with heart failure and depression and their effect on mortality. Am. J. Cardiol. 124, 746–750. doi: 10.1016/j.amjcard.2019.05.054

PubMed Abstract | CrossRef Full Text | Google Scholar

Kitada, Y., Miyauchi, T., Kosasa, T., and Satoh, S. (1983). Further studies on the suppressing effect of isoproterenol on the immobility-reducing action of desipramine in the forced swimming test. Jpn. J. Pharmacol. 33, 867–873. doi: 10.1254/jjp.33.867

PubMed Abstract | CrossRef Full Text | Google Scholar

Koella, W. P. (1985). CNS-related (side-)effects of blockers with special reference to mechanisms of action. Eur. J. Clin. Pharmacol. 28, 55–63. doi: 10.1007/BF00543711

PubMed Abstract | CrossRef Full Text | Google Scholar

Kotagale, N. R., Tripathi, S. J., Aglawe, M. M., Chopde, C. T., Umekar, M. J., and Taksande, B. G. (2013). Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim test. Pharmacol. Biochem. Behav. 107, 42–47. doi: 10.1016/j.pbb.2013.03.019

PubMed Abstract | CrossRef Full Text | Google Scholar

Kurosawa, N., Shimizu, K., and Seki, K. (2016). The development of depression-like behavior is consolidated by IL-6-induced activation of locus coeruleus neurons and IL-1β-induced elevated leptin levels in mice. Psychopharmacology 233, 1725–1737. doi: 10.1007/s00213-015-4084-x

PubMed Abstract | CrossRef Full Text | Google Scholar

Liu, X., Peprah, D., and Gershenfeld, H. K. (2003). Tail-suspension induced hyperthermia: a new measure of stress reactivity. J. Psychiatr. Res. 37, 249–259. doi: 10.1016/s0022-3956(03)00004-9

PubMed Abstract | CrossRef Full Text | Google Scholar

Maity, S., Chandanathil, M., Millis, R. M., and Connor, S. A. (2020). Norepinephrine stabilizes translation-dependent, homosynaptic long-term potentiation through mechanisms requiring the cAMP sensor Epac, mTOR and MAPK. Eur. J. Neurosci. 52, 3679–3688. doi: 10.1111/ejn.14735

PubMed Abstract | CrossRef Full Text | Google Scholar

Malikowska, N., Fijałkowski, Ł., Nowaczyk, A., Popik, P., and Sałat, K. (2017). Antidepressant-like activity of venlafaxine and clonidine in mice exposed to single prolonged stress—a model of post-traumatic stress disorder. Pharmacodynamic and molecular docking studies. Brain Res. 1673, 1–10. doi: 10.1016/j.brainres.2017.08.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Malinge, M., Bourin, M., Colombel, M. C., and Larousse, C. (1988). Additive effects of clonidine and antidepressant drugs in the mouse forced-swimming test. Psychopharmacology 96, 104–109. doi: 10.1007/BF02431541

PubMed Abstract | CrossRef Full Text | Google Scholar

Malinge, M., Colombel, M., and Bourin, M. (1989). Mechanism of action of clonidine in the forced-swimming test in mice. Encephale 15, 37–41.

PubMed Abstract | Google Scholar

Masuda, Y., Ohnuma, S., and Sugiyama, T. (2001). α 2-adrenoceptor activity induces the antidepressant-like glycolipid in mouse forced swimming. Methods Find. Exp. Clin. Pharmacol. 23, 19–21. doi: 10.1358/mf.2001.23.1.619175

PubMed Abstract | CrossRef Full Text | Google Scholar

Miller, A. H., Maletic, V., and Raison, C. L. (2009). Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 65, 732–741. doi: 10.1016/j.biopsych.2008.11.029

PubMed Abstract | CrossRef Full Text | Google Scholar

Mineur, Y. S., Bentham, M. P., Zhou, W.-L., Plantenga, M. E., McKee, S. A., and Picciotto, M. R. (2015). Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice. Psychopharmacology 232, 3539–3549. doi: 10.1007/s00213-015-4001-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Mineur, Y. S., Cahuzac, E. L., Mose, T. N., Bentham, M. P., Plantenga, M. E., Thompson, D. C., et al. (2018). Interaction between noradrenergic and cholinergic signaling in amygdala regulates anxiety- and depression-related behaviors in mice. Neuropsychopharmacology 43, 2118–2125. doi: 10.1038/s41386-018-0024-x

PubMed Abstract | CrossRef Full Text | Google Scholar

Mitchell, P. B. (2004). Therapeutic drug monitoring of non-tricyclic antidepressant drugs. Clin. Chem. Lab. Med. 42, 1212–1218. doi: 10.1515/CCLM.2004.243

PubMed Abstract | CrossRef Full Text | Google Scholar

Muguruza, C., Rodríguez, F., Rozas, I., Meana, J. J., Urigüen, L., and Callado, L. F. (2013). Antidepressant-like properties of three new α2-adrenoceptor antagonists. Neuropharmacology 65, 13–19. doi: 10.1016/j.neuropharm.2012.09.003

PubMed Abstract | CrossRef Full Text | Google Scholar

Muthalif, M. M., Benter, I. F., Karzoun, N., Fatima, S., Harper, J., Uddin, M. R., et al. (1998). 20-Hydroxyeicosatetraenoic acid mediates calcium/calmodulin-dependent protein kinase II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells. Proc. Natl. Acad. Sci. U S A 95, 12701–12706. doi: 10.1073/pnas.95.21.12701

PubMed Abstract | CrossRef Full Text | Google Scholar

Nemeth, D. G., and Mckenzie Chustz, K. (2020). Treating comorbid childhood bipolar disorder and ADHD. CNS Spectr. 25, 283–284. doi: 10.1017/S1092852920000486

CrossRef Full Text | Google Scholar

O’Neill, M. F., Osborne, D. J., Woodhouse, S. M., and Conway, M. W. (2001). Selective imidazoline I2 ligands do not show antidepressant-like activity in the forced swim test in mice. J. Psychopharmacol. 15, 18–22. doi: 10.1177/026988110101500104

PubMed Abstract | CrossRef Full Text | Google Scholar

Overstreet, D. H., Stemmelin, J., and Griebel, G. (2008). Confirmation of antidepressant potential of the selective β3 adrenoceptor agonist amibegron in an animal model of depression. Pharmacol. Biochem. Behav. 89, 623–626. doi: 10.1016/j.pbb.2008.02.020

PubMed Abstract | CrossRef Full Text | Google Scholar

Parale, M. P., Chakravarti, S., and Kulkarni, S. K. (1987). Evidence of β-adrenergic involvement in forced swimming-induced behavioural despair of mice. Methods Find. Exp. Clin. Pharmacol. 9, 35–38.

PubMed Abstract | Google Scholar

Parale, M. P., and Kulkarni, S. K. (1986). Clonidine—induced behavioural despair in mice: reversal by antidepressants. Psychopharmacology 89, 171–174. doi: 10.1007/BF00310623

PubMed Abstract | CrossRef Full Text | Google Scholar

Park, M. J., Yoo, S. W., Choe, B. S., Dantzer, R., and Freund, G. G. (2012). Acute hypoglycemia causes depressive-like behaviors in mice. Metab. Clin. Exp. 61, 229–236. doi: 10.1016/j.metabol.2011.06.013

PubMed Abstract | CrossRef Full Text | Google Scholar

Pesarico, A. P., Sampaio, T. B., Stangherlin, E. C., Mantovani, A. C., Zeni, G., and Nogueira, C. W. (2014). The antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in the mouse forced swimming test is mediated by serotonergic and dopaminergic systems. Prog. Neuropsychopharmacol. Biol. Psychiatry 54, 179–186. doi: 10.1016/j.pnpbp.2014.06.001

PubMed Abstract | CrossRef Full Text | Google Scholar

Polis, A. J., Fitzgerald, P. J., Hale, P. J., and Watson, B. O. (2019). Rodent ketamine depression-related research: finding patterns in a literature of variability. Behav. Brain Res. 376:112153. doi: 10.1016/j.bbr.2019.112153

PubMed Abstract | CrossRef Full Text | Google Scholar

Poncelet, M., Martin, P., Danti, S., Simon, P., and Soubrié, P. (1987). Noradrenergic rather than GABAergic processes as the common mediation of the antidepressant profde of GABA agonists and imipramine-like drugs in animals. Pharmacol. Biochem. Behav. 28, 321–326. doi: 10.1016/0091-3057(87)90447-3

PubMed Abstract | CrossRef Full Text | Google Scholar

Redrobe, J. P., and Bourin, M. (1997). Effects of pretreatment with clonidine, lithium and quinine on the activities of antidepressant drugs in the mouse tail suspension test. Fundam. Clin. Pharmacol. 11, 381–386. doi: 10.1111/j.1472-8206.1997.tb00199.x

PubMed Abstract | CrossRef Full Text | Google Scholar

Redrobe, J. P., and Bourin, M. (1998). Clonidine potentiates the effects of 5-HT, 5-HT and 5-HT 1A 1B 2A/2C antagonists and 8-OH-DPAT in the mouse forced swimming test. Eur. Neuropsychopharmacol. 8, 169–173. doi: 10.1016/s0924-977x(97)00073-4

PubMed Abstract | CrossRef Full Text | Google Scholar

Rénéric, J.-P., Bouvard, M., and Stinus, L. (2002). In the rat forced swimming test, chronic but not subacute administration of dual 5-HT/NA antidepressant treatments may produce greater effects than selective drugs. Behav. Brain Res. 136, 521–532. doi: 10.1016/s0166-4328(02)00203-6

PubMed Abstract | CrossRef Full Text | Google Scholar

Ribeiro, C. A. S., and Pupo, A. S. (2015). Involvement of α1B-adrenoceptors in the anti-immobility effect of imipramine in the tail suspension test. Eur. J. Pharmacol. 750, 39–42. doi: 10.1016/j.ejphar.2015.01.010

PubMed Abstract | CrossRef Full Text | Google Scholar

Rosen, R., and Kostis, J. (1985). Biobehavioral sequellae associated with adrenergic-inhibiting antihypertensive agents: a critical review. Health Psychol. 4, 579–604. doi: 10.1037//0278-6133.4.6.579

PubMed Abstract | CrossRef Full Text | Google Scholar

Ruhé, H. G., Huyser, J., Swinkels, J. A., and Schene, A. H. (2006). Switching antidepressants after a first selective serotonin reuptake inhibitor in major depressive disorder: a systematic review. J. Clin. Psychiatry 67, 1836–1855. doi: 10.4088/jcp.v67n1203

PubMed Abstract | CrossRef Full Text | Google Scholar

Sallinen, J., Haapalinna, A., MacDonald, E., Viitamaa, T., LähdesmäKi, J., Rybnikova, E., et al. (1999). Genetic alteration of the 2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels. Mol. Psychiatry 4, 443–452. doi: 10.1038/sj.mp.4000543

PubMed Abstract | CrossRef Full Text | Google Scholar

Schildkbaut, J. J. (1965). The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am. J. Psychiatry 122, 509–522. doi: 10.1176/ajp.122.5.509

PubMed Abstract | CrossRef Full Text | Google Scholar

Schmaal, L., Hibar, D. P., Sämann, P. G., Hall, G. B., Baune, B. T., Jahanshad, N., et al. (2017). Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA major depressive disorder working group. Mol. Psychiatry 22, 900–909. doi: 10.1038/mp.2016.60

PubMed Abstract | CrossRef Full Text | Google Scholar

Schreiber, R., and De Vry, J. (1993). Neuroanatomical basis for the antidepressant-like effects of the 5-HT(1A) receptor agonists 8-OH-DPAT and ipsapirone in the rat forced swimming test. Behav. Pharmacol. 4, 625–636. doi: 10.1097/00008877-199312000-00008

PubMed Abstract | CrossRef Full Text | Google Scholar

Sekio, M., and Seki, K. (2015). Lipopolysaccharide-induced depressive-like behavior is associated with α1-adrenoceptor dependent downregulation of the membrane GluR1 subunit in the mouse medial prefrontal cortex and ventral tegmental area. Int. J. Neuropsychopharmacol. 18:pyu005. doi: 10.1093/ijnp/pyu005

PubMed Abstract | CrossRef Full Text | Google Scholar

Skrebuhhova, T., Allikmets, L., and Matto, V. (1999). Effects of anxiogenic drugs in rat forced swimming test. Methods Find. Exp. Clin. Pharmacol. 21, 173–178. doi: 10.1358/mf.1999.21.3.534826

PubMed Abstract | CrossRef Full Text | Google Scholar

Stemmelin, J., Cohen, C., Terranova, J.-P., Lopez-Grancha, M., Pichat, P., Bergis, O., et al. (2008). Stimulation of the β3-adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychopharmacology 33, 574–587. doi: 10.1038/sj.npp.1301424

PubMed Abstract | CrossRef Full Text | Google Scholar

Stemmelin, J., Cohen, C., Yalcin, I., Keane, P., and Griebel, G. (2010). Implication of β3-adrenoceptors in the antidepressant-like effects of amibegron using Adrb3 knockout mice in the chronic mild stress. Behav. Brain Res. 206, 310–312. doi: 10.1016/j.bbr.2009.09.003

PubMed Abstract | CrossRef Full Text | Google Scholar

Stone, E. A., Lin, Y., Sarfraz, Y., and Quartermain, D. (2011). Antidepressant-like action of intracerebral 6-fluoronorepinephrine, a selective full α-adrenoceptor agonist. Int. J. Neuropsychopharmacol. 14, 319–331. doi: 10.1017/S1461145710000507

PubMed Abstract | CrossRef Full Text | Google Scholar

Stone, E. A., and Quartermain, D. (1999). α-1-noradrenergic neurotransmission, corticosterone, and behavioral depression. Biol. Psychiatry 46, 1287–1300. doi: 10.1016/s0006-3223(99)00234-6

PubMed Abstract | CrossRef Full Text | Google Scholar

Sugimoto, Y., Yamamoto, M., Tagawa, N., Kobayashi, Y., Mitsui-Saitoh, K., Hotta, Y., et al. (2011). Differences between mice strains in response to paroxetine in the forced swimming test: involvement of serotonergic or noradrenergic systems. Eur. J. Pharmacol. 672, 121–125. doi: 10.1016/j.parkreldis.2021.08.019

PubMed Abstract | CrossRef Full Text | Google Scholar

Taksande, B. G., Kotagale, N. R., Tripathi, S. J., Ugale, R. R., and Chopde, C. T. (2009). Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine. Neuropharmacology 57, 415–424. doi: 10.1016/j.neuropharm.2009.06.035

PubMed Abstract | CrossRef Full Text | Google Scholar

Tamburella, A., Micale, V., Leggio, G. M., and Drago, F. (2010). The β3 adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. Eur. Neuropsychopharmacol. 20, 704–713. doi: 10.1016/j.euroneuro.2010.04.006

PubMed Abstract | CrossRef Full Text | Google Scholar

Tanis, K. Q., and Duman, R. S. (2007). Intracellular signaling pathways pave roads to recovery for mood disorders. Ann. Med. 39, 531–544. doi: 10.1080/07853890701483270

PubMed Abstract | CrossRef Full Text | Google Scholar

Teste, J., Martin, I., and Rinjard, P. (1990). Electrotherapy in mice: dopaminergic and noradrenergic effects in the Tail Suspension Test. Fund. Clin. Pharmacol. 4, 39–47. doi: 10.1111/j.1472-8206.1990.tb01015.x

PubMed Abstract | CrossRef Full Text | Google Scholar

Ulrich, S., Ricken, R., Buspavanich, P., Schlattmann, P., and Adli, M. (2020). Efficacy and adverse effects of tranylcypromine and tricyclic antidepressants in the treatment of depression: a systematic review and comprehensive meta-analysis. J. Clin. Psychopharmacol. 40, 63–74. doi: 10.1097/JCP.0000000000001153

PubMed Abstract | CrossRef Full Text | Google Scholar

Uys, M. M., Shahid, M., Sallinen, J., and Harvey, B. H. (2017). The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat. Behav. Pharmacol. 28, 9–18. doi: 10.1097/FBP.0000000000000261

PubMed Abstract | CrossRef Full Text | Google Scholar

Vaidya, V. A., and Duman, R. S. (2001). Depression—emerging insights from neurobiology. Br. Med. Bull. 57, 61–79. doi: 10.1093/bmb/57.1.61

PubMed Abstract | CrossRef Full Text | Google Scholar

Van Gaalen, M., Kawahara, H., Kawahara, Y., and Westerink, B. (1997). The locus coeruleus noradrenergic system in the rat brain studied by dual-probe microdialysis. Brain Res. 763, 56–62. doi: 10.1016/s0006-8993(97)00416-2

PubMed Abstract | CrossRef Full Text | Google Scholar

Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., and Arnsten, A. F. T. (2007). Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nat. Neurosci. 10, 376–384. doi: 10.1038/nn1846

PubMed Abstract | CrossRef Full Text | Google Scholar

Waldmeier, P. C. (1981). Noradrenergic transmission in depression: under-or overfunction? Pharmakopsychiatria 14, 3–9. doi: 10.1055/s-2007-1019557

PubMed Abstract | CrossRef Full Text | Google Scholar

Wohleb, E. S., Franklin, T., Iwata, M., and Duman, R. S. (2016). Integrating neuroimmune systems in the neurobiology of depression. Nat. Rev. Neurosci. 17, 497–511. doi: 10.1038/nrn.2016.69

PubMed Abstract | CrossRef Full Text | Google Scholar

Wu, Z. H., Zhang, Q. J., Du, C. X., Xi, Y., Li, W. J., Guo, F. Y., et al. (2017). Prelimbic α1-adrenoceptors are involved in the regulation of depressive-like behaviors in the hemiparkinsonian rats. Brain Res. Bull. 134, 99–108. doi: 10.1016/j.brainresbull.2017.07.011

PubMed Abstract | CrossRef Full Text | Google Scholar

Yanagawa, Y., Matsumoto, M., and Togashi, H. (2010). Enhanced dendritic cell antigen uptake via α 2 adrenoceptor-mediated PI3K activation following brief exposure to noradrenaline. J. Immunol. 185, 5762–5768. doi: 10.4049/jimmunol.1001899

PubMed Abstract | CrossRef Full Text | Google Scholar

Zaidi, S., Atrooz, F., Valdez, D., Liu, H., Kochi, C., Bond, R. A., et al. (2020). Protective effect of propranolol and nadolol on social defeat-induced behavioral impairments in rats. Neurosci. Lett. 725:134892. doi: 10.1016/j.neulet.2020.134892

PubMed Abstract | CrossRef Full Text | Google Scholar

Zeidan, M. P., Zomkowski, A. D. E., Rosa, A. O., Rodrigues, A. L. S., and Gabilan, N. H. (2007). Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test. Eur. J. Pharmacol. 565, 125–131. doi: 10.1016/j.ejphar.2007.03.027

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhang, H.-T., Whisler, L. R., Huang, Y., Xiang, Y., and O’Donnell, J. M. (2009). Postsynaptic α-2 adrenergic receptors are critical for the antidepressant-like effects of desipramine on behavior. Neuropsychopharmacology 34, 1067–1077. doi: 10.1038/npp.2008.184

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: norepinephrine, noradrenaline, serotonin, SSRI (selective serotonergic reuptake inhibitors), propranolol, clonidine, guanfacine, prazosin

Citation: Fitzgerald PJ (2021) Are Noradrenergic Transmission Reducing Drugs Antidepressants? Front. Behav. Neurosci. 15:673634 doi: 10.3389/fnbeh.2021.673634

Received: 28 February 2021; Accepted: 07 September 2021;
Published: 30 September 2021.

Edited by:

Ravid Doron, Open University of Israel, Israel

Reviewed by:

Juan Francisco Rodríguez-Landa, Universidad Veracruzana, Mexico
Keren Nitzan, Open University of Israel, Israel

Copyright © 2021 Fitzgerald. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Paul J. Fitzgerald, pfitz1940@gmail.com

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