Skip to main content

CORRECTION article

Front. Neuroanat., 06 July 2021

Corrigendum: Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies

  • 1Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT, United States
  • 2Department of Cellular & Molecular Physiology, Yale School of Medicine, Yale University, New Haven, CT, United States

A Corrigendum on
Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies

by Nguyen, L. H., and Bordey, A. (2021). Front. Neuroanat. 15:664695. doi: 10.3389/fnana.2021.664695

In the original article, there was a mistake in Table 1 as published.

Three rows of cited work (Rheb S16H, Hsieh et al., 2020; Rheb P37L, Reijnders et al., 2017, and Rheb P37L, Onori et al., 2020) were omitted.

Additionally, one of the cited studies (Rheb S16H) had the incorrect reference Zhang et al., 2019. Zhang, L., Huang, T., Teaw, S., and Bordey, A. (2019). Hypervascularization in mTOR-dependent focal and global cortical malformations displays differential rapamycin sensitivity. Epilepsia 60, 1255–1265. doi: 10.1111/epi.15969. Instead, it should be Zhang et al., 2020. Zhang, L., Huang, T., Teaw, S., Nguyen, L. H., Hsieh, L. S., Gong, X., et al. (2020). Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations. Sci. Transl. Med. 12:eaay0289. doi: 10.1126/scitranslmed.aay0289.

The corrected Table 1 appears below.

TABLE 1
www.frontiersin.org

Table 1. Summary of IUE-based rodent models of mTORopathies.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

References

Baek, S. T., Copeland, B., Yun, E. J., Kwon, S. K., Guemez-Gamboa, A., Schaffer, A. E., et al. (2015). An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development. Nat. Med. 21, 1445–1454. doi: 10.1038/nm.3982

PubMed Abstract | CrossRef Full Text | Google Scholar

Chen, F., Rosiene, J., Che, A., Becker, A., and LoTurco, J. (2015). Tracking and transforming neocortical progenitors by CRISPR/Cas9 gene targeting and piggyBac transposase lineage labeling. Development 142, 3601–3611. doi: 10.1242/dev.118836

PubMed Abstract | CrossRef Full Text | Google Scholar

Dawson, R. E., Nieto Guil, A. F., Robertson, L. J., Piltz, S. G., Hughes, J. N., and Thomas, P. Q. (2020). Functional screening of GATOR1 complex variants reveals a role for mTORC1 deregulation in FCD and focal epilepsy. Neurobiol. Dis. 134:104640. doi: 10.1016/j.nbd.2019.104640

PubMed Abstract | CrossRef Full Text | Google Scholar

Feliciano, D. M., Su, T., Lopez, J., Platel, J. C., and Bordey, A. (2011). Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. J. Clin. Invest. 121, 1596–1607. doi: 10.1172/jci44909

PubMed Abstract | CrossRef Full Text | Google Scholar

Gong, X., Zhang, L., Huang, T., Lin, T. V., Miyares, L., Wen, J., et al. (2015). Activating the translational repressor 4E-BP or reducing S6K-GSK3beta activity prevents accelerated axon growth induced by hyperactive mTOR in vivo. Hum. Mol. Genet. 24, 5746–5758. doi: 10.1093/hmg/ddv295

PubMed Abstract | CrossRef Full Text | Google Scholar

Goz, R. U., Akgul, G., and LoTurco, J. J. (2020). BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons. J. Neurophysiol. 123, 2449–2464. doi: 10.1152/jn.00523.2019

PubMed Abstract | CrossRef Full Text | Google Scholar

Hanai, S., Sukigara, S., Dai, H., Owa, T., Horike, S. I., Otsuki, T., et al. (2017). Pathologic active mTOR mutation in brain malformation with intractable epilepsy leads to cell-autonomous migration delay. Am. J. Pathol. 187, 1177–1185. doi: 10.1016/j.ajpath.2017.01.015

PubMed Abstract | CrossRef Full Text | Google Scholar

Hsieh, L. S., Wen, J. H., Claycomb, K., Huang, Y., Harrsch, F. A., Naegele, J. R., et al. (2016). Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement. Nat. Commun. 7:11753. doi: 10.1038/ncomms11753

PubMed Abstract | CrossRef Full Text

Hsieh, L. S., Wen, J. H., Nguyen, L. H., Zhang, L., Getz, S. A., Torres-Reveron, J., et al. (2020). Ectopic HCN4 expression drives mTOR-dependent epilepsy in mice. Sci. Transl. Med. 12:eabc1492. doi: 10.1126/scitranslmed.abc1492

PubMed Abstract | CrossRef Full Text | Google Scholar

Hu, S., Knowlton, R. C., Watson, B. O., Glanowska, K. M., Murphy, G. G., Parent, J. M., et al. (2018). Somatic Depdc5 deletion recapitulates electroclinical features of human focal cortical dysplasia type IIA. Ann. Neurol. 84, 140–146. doi: 10.1002/ana.25272

PubMed Abstract | CrossRef Full Text | Google Scholar

Iffland, P. H., Everett, M. E., Cobb-Pitstick, K. M., Bowser, L. E., Barnes, A. E., Babus, J. K., et al. (2020). NPRL3: direct effects on human phenotypic variability, mTOR signaling, subcellular mTOR localization, cortical lamination, and seizure susceptibility. bioRxiv doi: 10.1101/2020.12.11.421214

CrossRef Full Text | Google Scholar

Itoh, Y., Higuchi, M., Oishi, K., Kishi, Y., Okazaki, T., Sakai, H., et al. (2016). PDK1–Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex. Proc. Natl. Acad. Sci. U.S.A. 113, E2955–E2964. doi: 10.1073/pnas.1516321113

PubMed Abstract | CrossRef Full Text | Google Scholar

Kassai, H., Sugaya, Y., Noda, S., Nakao, K., Maeda, T., Kano, M., et al. (2014). Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. Cell Rep. 7, 1626–1639. doi: 10.1016/j.celrep.2014.04.048

PubMed Abstract | CrossRef Full Text | Google Scholar

Kim, J. K., Cho, J., Kim, S. H., Kang, H. C., Kim, D. S., Kim, V. N., et al. (2019). Brain somatic mutations in MTOR reveal translational dysregulations underlying intractable focal epilepsy. J. Clin. Invest. 129, 4207–4223. doi: 10.1172/jci127032

PubMed Abstract | CrossRef Full Text | Google Scholar

Konno, D., Yoshimura, S., Hori, K., Maruoka, H., and Sobue, K. (2005). Involvement of the phosphatidylinositol 3-kinase/rac1 and cdc42 pathways in radial migration of cortical neurons. J. Biol. Chem. 280, 5082–5088. doi: 10.1074/jbc.m408251200

PubMed Abstract | CrossRef Full Text | Google Scholar

Lim, J. S., Gopalappa, R., Kim, S. H., Ramakrishna, S., Lee, M., Kim, W. I., et al. (2017). Somatic mutations in TSC1 and TSC2 cause focal cortical dysplasia. Am. J. Hum. Genet. 100, 454–472. doi: 10.1016/j.ajhg.2017.01.030

PubMed Abstract | CrossRef Full Text | Google Scholar

Lim, J. S., Kim, W. I., Kang, H. C., Kim, S. H., Park, A. H., Park, E. K., et al. (2015). Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nat. Med. 21, 395–400. doi: 10.1038/nm.3824

PubMed Abstract | CrossRef Full Text | Google Scholar

Lin, T. V., Hsieh, L., Kimura, T., Malone, T. J., and Bordey, A. (2016). Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration. Proc. Natl. Acad. Sci. U.S.A. 113, 11330–11335. doi: 10.1073/pnas.1605740113

PubMed Abstract | CrossRef Full Text | Google Scholar

Moon, U. Y., Park, J. Y., Park, R., Cho, J. Y., Hughes, L. J., McKenna, J. III, et al. (2015). Impaired Reelin-Dab1 signaling contributes to neuronal migration deficits of tuberous sclerosis complex. Cell Rep. 12, 965–978. doi: 10.1016/j.celrep.2015.07.013

PubMed Abstract | CrossRef Full Text | Google Scholar

Nguyen, L. H., Mahadeo, T., and Bordey, A. (2019). mTOR hyperactivity levels influence the severity of epilepsy and associated neuropathology in an experimental model of tuberous sclerosis complex and focal cortical dysplasia. J. Neurosci. 39, 2762–2773. doi: 10.1523/jneurosci.2260-18.2019

PubMed Abstract | CrossRef Full Text | Google Scholar

Onori, M. P., Koene, L. M. C., Schafer, C. B., Nellist, M., de Brito van Velze, M., et al. (2020). RHEB/mTOR-hyperactivity causing cortical malformations drives seizures through increased axonal connectivity. bioRxiv doi: 10.1101/2020.07.08.189399

CrossRef Full Text | Google Scholar

Orlova, K. A., Parker, W. E., Heuer, G. G., Tsai, V., Yoon, J., Baybis, M., et al. (2010). STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice. J. Clin. Invest. 120, 1591–1602. doi: 10.1172/jci41592

PubMed Abstract | CrossRef Full Text | Google Scholar

Park, S. M., Lim, J. S., Ramakrishina, S., Kim, S. H., Kim, W. K., Lee, J., et al. (2018). Brain somatic mutations in MTOR disrupt neuronal ciliogenesis, leading to focal cortical dyslamination. Neuron 99, 83–97e87. doi: 10.1016/j.neuron.2018.05.039

PubMed Abstract | CrossRef Full Text | Google Scholar

Parker, W. E., Orlova, K. A., Parker, W. H., Birnbaum, J. F., Krymskaya, V. P., Goncharov, D. A., et al. (2013). Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder. Sci. Transl. Med. 5:182ra153. doi: 10.1126/scitranslmed.3005271

PubMed Abstract | CrossRef Full Text | Google Scholar

Pelorosso, C., Watrin, F., Conti, V., Buhler, E., Gelot, A., Yang, X., et al. (2019). Somatic double-hit in MTOR and RPS6 in hemimegalencephaly with intractable epilepsy. Hum. Mol. Genet. 28, 3755–3765. doi: 10.1093/hmg/ddz194

PubMed Abstract | CrossRef Full Text | Google Scholar

Reijnders, M. R. F., Kousi, M., van Woerden, G. M., Klein, M., Bralten, J., Mancini, G. M. S., et al. (2017). Variation in a range of mTOR-related genes associates with intracranial volume and intellectual disability. Nat. Commun. 8:1052. doi: 10.1038/s41467-017-00933-6

PubMed Abstract | CrossRef Full Text | Google Scholar

Ribierre, T., Deleuze, C., Bacq, A., Baldassari, S., Marsan, E., Chipaux, M., et al. (2018). Second-hit mosaic mutation in mTORC1 repressor DEPDC5 causes focal cortical dysplasia-associated epilepsy. J. Clin. Invest. 128, 2452–2458. doi: 10.1172/jci99384

PubMed Abstract | CrossRef Full Text | Google Scholar

Sokolov, A. M., Seluzicki, C. M., Morton, M. C., and Feliciano, D. M. (2018). Dendrite growth and the effect of ectopic Rheb expression on cortical neurons. Neurosci. Lett. 671, 140–147. doi: 10.1016/j.neulet.2018.02.021

PubMed Abstract | CrossRef Full Text | Google Scholar

Tarkowski, B., Kuchcinska, K., Blazejczyk, M., and Jaworski, J. (2019). Pathological mTOR mutations impact cortical development. Hum. Mol. Genet. 28, 2107–2119. doi: 10.1093/hmg/ddz042

PubMed Abstract | CrossRef Full Text | Google Scholar

Tsai, V., Parker, W. E., Orlova, K. A., Baybis, M., Chi, A. W., Berg, B. D., et al. (2014). Fetal brain mTOR signaling activation in tuberous sclerosis complex. Cereb. Cortex 24, 315–327. doi: 10.1093/cercor/bhs310

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhang, L., Huang, T., Teaw, S., and Bordey, A. (2019). Hypervascularization in mTOR-dependent focal and global cortical malformations displays differential rapamycin sensitivity. Epilepsia 60, 1255–1265. doi: 10.1111/epi.15969

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhang, L., Huang, T., Teaw, S., Nguyen, L. H., Hsieh, L. S., Gong, X., et al. (2020). Filamin A inhibition reduces seizure activity in a mouse model of focal cortical malformations. Sci. Transl. Med. 12:eaay0289. doi: 10.1126/scitranslmed.aay0289

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhao, S., Li, Z., Zhang, M., Zhang, L., Zheng, H., Ning, J., et al. (2019). A brain somatic RHEB doublet mutation causes focal cortical dysplasia type II. Exp. Mol. Med. 51:84. doi: 10.1038/s12276-019-0277-4

PubMed Abstract | CrossRef Full Text | Google Scholar

Zhong, S., Zhao, Z., Xie, W., Cai, Y., Zhang, Y., Ding, J., et al. (2021). GABAergic interneuron and neurotransmission are mTOR-dependently disturbed in experimental focal cortical dysplasia. Mol. Neurobiol. 58, 156–169. doi: 10.1007/s12035-020-02086-y

PubMed Abstract | CrossRef Full Text | Google Scholar

Keywords: neuron migration, tuberous sclerosis complex, focal cortical dysplasia, GATOR1 complex, in utero electroporation, mTOR, cortical development, epilepsy

Citation: Nguyen LH and Bordey A (2021) Corrigendum: Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies. Front. Neuroanat. 15:715363. doi: 10.3389/fnana.2021.715363

Received: 26 May 2021; Accepted: 28 May 2021;
Published: 06 July 2021.

Edited and reviewed by: Alfonso Represa, INSERM U901 Institut de Neurobiologie de la Méditerranée, France

Copyright © 2021 Nguyen and Bordey. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Angélique Bordey, angelique.bordey@yale.edu

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.