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MINI REVIEW article

Front. Immunol.
Sec. Inflammation
Volume 15 - 2024 | doi: 10.3389/fimmu.2024.1495853
This article is part of the Research Topic Hiding Features in Myeloid Cells: Metabolism Preference in Different Disease Models View all 8 articles

Lipid Metabolism in Myeloid Cell Function and Chronic Inflammatory Diseases

Provisionally accepted
Ayaka Ito Ayaka Ito *Takayoshi Suganami Takayoshi Suganami
  • Nagoya University, Nagoya, Japan

The final, formatted version of the article will be published soon.

    Immune cells adapt their metabolism in response to their differentiation and activation status to meet the energy demands for an appropriate immune response. Recent studies have elucidated that during immune cell metabolic reprogramming, lipid metabolism, including lipid uptake, de novo lipid synthesis and fatty acid oxidation, undergoes significant alteration, resulting in dynamic changes in the quantity and quality of intracellular lipids. Given that lipids serve as an energy source and structural components of cellular membranes, they have important implications for physiological function. Myeloid cells, which are essential in bridging innate and adaptive immunity, are sensitive to these changes. Dysregulation of lipid metabolism in myeloid cells can result in immune dysfunction, chronic inflammation and impaired resolution of inflammation. Understanding the mechanism by which lipids regulate immune cell function might provide novel therapeutic insights into chronic inflammatory diseases, including metabolic diseases, autoimmune diseases and cancer.

    Keywords: Lipid Metabolism, Immunometabolism, Autoimmunity, Cancer, metabolic disease

    Received: 13 Sep 2024; Accepted: 30 Dec 2024.

    Copyright: © 2024 Ito and Suganami. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ayaka Ito, Nagoya University, Nagoya, Japan

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