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MINI REVIEW article

Front. Cardiovasc. Med.
Sec. Lipids in Cardiovascular Disease
Volume 11 - 2024 | doi: 10.3389/fcvm.2024.1510148
This article is part of the Research Topic Evidence of Atherogenic Lipoproteins: what we gain from in vitro and in vivo research View all 10 articles

Frontiers in Cardiovascular Medicine-Collection: "Evidence of Atherogenic Lipoproteins: what we gain from in vitro and in vivo research" Mini-Review Bile acids and incretins as modulators of obesity-associated atherosclerosis

Provisionally accepted
Andrijana Kirsch Andrijana Kirsch Juergen Gindlhuber Juergen Gindlhuber Diana Zabini Diana Zabini Elena Osto Elena Osto *
  • Division of Physiology and Pathophysiology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria

The final, formatted version of the article will be published soon.

    Obesity is one of the major global health concerns of the 21 st century, associated with many comorbidities such as type 2 diabetes mellitus (T2DM), metabolic associated steatotic liver disease and early and aggressive atherosclerotic cardiovascular disease, which is the leading cause of death worldwide. Bile acids (BAs) and incretins are gut hormones involved in digestion and absorption of fatty acids, and insulin secretion, respectively. In recent years BAs and incretins are increasingly recognized as key signaling molecules, which target multiple tissues and organs, beyond the gastro-intestinal system. Moreover, incretin-based therapy has revolutionized the treatment of T2DM and obesity. This mini review highlights the current knowledge about dysregulations in BA homeostasis in obesity with a special focus on atherosclerosis as well as athero-modulating roles of incretins and currently available incretinbased therapies.

    Keywords: cardiovascular disease, Obesity, gut hormones, Lipoproteins, Atherosclerosis

    Received: 12 Oct 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Kirsch, Gindlhuber, Zabini and Osto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Elena Osto, Division of Physiology and Pathophysiology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.