- 1Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy
- 2Applied Research Division for Cognitive and Psychological Science, Istituto Europeo di Oncologia, Milan, Italy
In recent years, technology has been developed as an important resource for health care management, especially in regard to chronic conditions. In the broad field of eHealth, mobile technology (mHealth) is increasingly used to empower patients not only in disease management but also in the achievement of positive experiences and experiential growth. mHealth tools are considered powerful because, unlike more traditional Internet-based tools, they allow patients to be continuously monitored and followed by their own mobile devices and to have continual access to resources (e.g., mobile apps or functions) supporting health care management activities. However, the literature has shown that, in many cases, such technology not accepted and/or adopted in the long term by its users. To address this issue, this article reviews the main factors influencing mHealth technology acceptance/adoption in health care. Finally, based on the main aspects emerging from the review, we propose an innovative approach to mHealth design and implementation, namely P5 mHealth. Relying on the P5 approach to medicine and health care, this approach provides design suggestions to address mHealth adoption issues already at the initial stages of development of the technologies.
Introduction
Chronic conditions pose challenges to health systems worldwide. While acute diseases can be treated by means of ad hoc therapy, chronic conditions often need to be managed and contained from onset (or diagnosis) to death, with very limited possibilities of complete recovery. Such a scenario requires continuous attention and availability from the health provider as well as commitment from the patient, who must adhere to long-term therapy and change his or her lifestyle. Moreover, chronic condition management often extends the demands of care to other figures, such as patients’ caregivers, organizations, and institutions. In recent years, new technologies have emerged as an extraordinary resource to help achieve these aims (Wiecha and Pollard, 2004; Castelnuovo et al., 2015a; Gorini et al., 2016).
In the health sector, new technologies for health (eHealth) are recognized as having a great impact on health promotion and management (Bert et al., 2014; Mirkovic et al., 2014; Barello et al., 2016; Hood et al., 2016; Jacobs et al., 2016). These tools make it possible to develop and implement integrated, sustainable, patient-centered services, and promote an effective exchange between patient and doctor, with the patient taking an active role in the health care process (Samoocha et al., 2010; Barello et al., 2016). Such health technologies not only empower and facilitate the administration of continual care but also offer opportunities for maintaining patients’ active engagement in the care process by promoting patients’ psychological skills (e.g., health literacy, emotion regulation, adoption of healthy behaviors) and well-being outcomes. Eysenbach (2001) defined eHealth as a vehicle to enrich patients and stakeholders through the intersection of medical informatics and public health business. As such, eHealth promotes a new “state of mind” for medical professionals, marked by a global attitude and by the intention to improve health care locally, regionally, and worldwide.
In recent decades, eHealth has developed dramatically, consistent with the development of informatics and online technologies. One of these developments is mHealth, which refers to the implementation of mobile technologies as a tremendous tool to improve health outcomes (Free et al., 2013; Kumar et al., 2013; Lee et al., 2017) and to facilitate continuous health monitoring individually and from home (Stephens et al., 2017). Moreover, the global availability of mobile technologies and their ease of use have made them accessible to almost all of the population (Tokosi et al., 2017).
In recent years, mHealth obtained encouraging results in reinforcing healthy behaviors (Gurman et al., 2012; Hamine et al., 2015), mostly by using short message service (SMS) messages to improve treatment adherence; however, multiple systematic reviews still show mixed results on the effectiveness of mHealth interventions. Indeed, in spite of many studies identifying the notable advantages derived from the use of mHealth and demonstrating how these applications are appreciated by patients, acceptability, and adoption in the long term are still poor in many cases (Christensen et al., 2009; Tomlinson et al., 2013; Mohammadzadeh and Safdari, 2014; Castelnuovo et al., 2015b; Hamine et al., 2015; Guo et al., 2016; McKay et al., 2016). Also, health care apps often lack standard validation in terms of benefits, acceptance, costs, and risks (McKay et al., 2016).
Using the above-discussed evidence and controversy as a starting point, the aim of the present contribution is, after an analysis of the variables that influence mHealth technologies’ acceptance/adoption, to promote guidelines for future mHealth resources and applications.
Issues in mHealth Adoption
There are many factors that may influence the use of mobile apps to monitor patients’ health. The first of these is related to age and expertise with technology. Chronic diseases that require life-long management generally affect elderly patients. For this reason, mHealth apps are often targeted at middle-aged/elderly patients, who usually have limited experience with technologies (Mattsson et al., 2017; Loerzel et al., 2018). Numerous studies reveal that older patients are less likely than younger ones to use computers regularly and, in a more general sense, have limited access to common-use technological devices (Børøsund et al., 2013). The literature on technology acceptance shows that perceived utility, perceived ease of use, and computer self-efficacy (e.g., the belief that one can use digital technology effectively) are the most important variables influencing the adoption of technology, as well as the persistence in use when difficulties are encountered (Mun and Hwang, 2003; Wu and Tsai, 2006; Kim and Chang, 2007; Wangpipatwong et al., 2008; Ward, 2013). This evidence may explain why elderly patients are less prone than younger ones to use mHealth to manage their health.
Another important factor, related to the previous one, is usability. Numerous applications are designed according to generic usability principles (Pagliari, 2007; Stellefson et al., 2011). However, it is possible that elderly and/or chronic patients present specific characteristics that may generate usage issues, which are difficult to predict if a “generic” user is considered as a model for usability evaluations. For example, age-related declines in sensory abilities and visual acuity may affect the ability to discriminate important information in a graphically challenging visual field (Agree et al., 2015). Regarding the content of an app, elderly patients appreciate and better understand information presented in multiple formats (e.g., when text is combined with images or videos making it easier to understand) (Bolle et al., 2016). For these usability-related reasons, older patients generally less accustomed to mobile technology than younger patients (Børøsund et al., 2013; Miller et al., 2017).
Other possible important factors related to the use of mHealth in health care are related to patients’ preferences and their subjective, lived experience of illness. For examples, patients may not want to have “all” the information about their disease. Instead, they may desire to know only those indications that concern them personally. For this reason, they often prefer to interact directly with health professionals, who provide them with information regarding their specific case, instead of relying on information provided by the available app (Grimsbø et al., 2012). Moreover, the mobile tool could be perceived as a “substitute” for the relationship with the clinician; in other words, patients may believe that the technology is given to them as a surrogate for the clinician, and that this tool will thus reduce their ability to interact with their doctor (Goel et al., 2011; Kondylakis et al., 2013). Such a belief, albeit erroneous, often predicts technology refusal or abandonment in the long term (Benson and Dundis, 2003; Mohr et al., 2011).
The length of illness and the stage of disease are other aspects that can determine the use of health management apps. Research performed on an interactive application (WebChoice) reveals that metastatic patients are less prone to use it compared to those who have recently been diagnosed. Metastatic patients may feel that they have already enough information about the disease and how to manage it, making them feel that the applications are not very useful to them (Grimsbø et al., 2012; Ruland et al., 2013). In contrast, immediately after diagnosis, patients tend to search for a lot of information about their disease and its treatment. Indeed, information presented during the first consultation is often forgotten or very difficult to memorize because of patients’ emotional state (e.g., anxiety and fear) (Bolle et al., 2016), so external support can be very useful to recover this information.
Gender is another factor that influences the use of mHealth. Men and women are equally familiar with how to use health apps through a smartphone (McKay et al., 2016); however, men are typically more confident than women regarding their ability to use technology and their experience with it (Cassidy and Eachus, 2002; Durndell and Haag, 2002). Since, as noted above, computer self-efficacy is an important variable influencing technology acceptance, gender may also indirectly affect mHealth adoption.
Finally, psychological variables such as cognitive representation of the disease, distress, and anxiety may significantly influence the adoption of mHealth (Ruland et al., 2013; Beiwinkel et al., 2017). For example, having low self-control and self-efficacy could reduce patients’ confidence in their ability to deal with their symptoms (Gysels and Higginson, 2007). Furthermore, in some situations, interacting with mHealth apps creates a fear of “getting even more problems” (Kessel et al., 2017). Indeed, some health-related apps ask users to comply with novel requests for health management. For instance, patients may have to monitor their smartphones to respond to daily messages asking them to report information on a web-based platform (e.g., glycemic values in diabetes), or they may be asked to use various app functions frequently (e.g., playing with an educational serious game and filling in online questionnaires on their health status). If the patient is not convinced about the utility of these tools for his/her health management, such new commitments may be a source of further stress and, ultimately, of negative attitudes towards the treatment. In such situations, patients may not only abandon the mHealth tools but also lose faith in their health providers, resulting in detrimental effects on the effectiveness of the health management process as a whole. Also, patients do not always have good insight into their health conditions; as such, they may wrongly think that they do not need any kind of support from mHealth (Nijland et al., 2011), causing them to demonstrate active and voluntary resistance to any kind of proposed tools.
This review of the literature sheds some light on important demographic, user-experience-related, and psychological factors that may have an impact on mHealth acceptance by patients involved in interventions. It is certainly difficult to address all of these factors in any possible intervention involving mobile technology; however, a specific theoretical perspective, rooted in an approach to medicine and care, could be useful not only to adapt already-designed devices and applications but also to develop future mHealth tools. On the one side, these advanced resources would make good use of all the opportunities offered by mobile technologies; on the other side, they would be designed according to general principles allowing health professionals to consider in advance (and possibly avoid) the acceptance issues highlighted above.
A P5 mHealth Approach
Some years ago, a system approach called “P4 medicine” was proposed (Hood and Friend, 2011; Hood and Flores, 2012). This approach was intended as a sophisticated extension of what is usually called “personalized medicine.” Specifically, the four Ps referred to the Predictive, Personalized, Preventive, and Participatory aspects of clinical medicine (Price et al., 2009; Auffray et al., 2010). A few years later, a P5 medicine approach was proposed (Gorini and Pravettoni, 2011; Pravettoni and Gorini, 2011), where the fifth P referred to the Psycho-cognitive aspects that play a significant and unique role in the way in which an individual experiences emotional events, copes with illness, and makes decisions about his/her own health. The time is ripe to use the P5 approach in combination with the most recent advances in technology in order to challenge the health care and technology industries to find innovative and personalized ways to improve the overall quality of care. In particular, a P5 mHealth approach can be developed (see Figure 1).
Such an approach may lead to a new generation of mHealth apps based on the features reflecting the original P5 construct. Specifically, mHealth apps should be as follows:
Predictive
Collecting data on the patient’s current health state without the need for frequent physical encounters with the health care provider (physician, psychologist, nurse, etc.) will increase the amount of available information, allowing for a more precise prediction of the patient’s future health state. Specifically, mHealth apps can collect data by means of various peripherals and in-app tools. For example, they can collect physiological parameters through integration with wearable technologies (e.g., heart rate variability and skin conductance), or they can store user-generated information related to medical values (e.g., glycemic level in diabetes) (Fontecha et al., 2015; Os et al., 2017). Moreover, they can include ad hoc or validated questionnaires to be filled in by health providers, caregivers, and patients (e.g., data related to the patient’s functional or psychological status) (Gorini et al., 2015; Renzi et al., 2017). In most cases, such data are actually used for analyses to be included in scientific publications, but their utility for therapy and health management could be further exploited. Indeed, based on predictive models, mHealth tools of the future can provide specific information from autonomous data-analysis, in order to help both the physician and the patient to foresee the patient’s future health state, management issues, and possible modifications to the patient’s therapy regimen and/or health management activities, as well as interventions targeted to different aspects of the patient’s well-being (e.g., improving relaxation and positive emotions or promoting engagement in self-actualizing experiences).
Examples: Chih et al. (2011) used a mobile app with patients addicted to alcohol; implementing a Bayesian predictive model, they were able to predict the likelihood of relapse based on repeated self-report questionnaires investigating relapse history and psychological aspects related to the recovery progress. Wearable and mobile technology (e.g., actigraphy devices) have been used to satisfactorily predict factors relevant for quality of life, such as sleep efficiency based on physical activity during waking hours (Sathyanarayana et al., 2016).
Personalized
Apps’ functions and contents (including requested information, feedback to the patients, etc.) should be tailored to the patient’s individual bio-psycho-social characteristics to provide more useful, more accepted by patients, and non-redundant information (Gorini et al., 2015; Pravettoni et al., 2016). Moreover, the personalization factor also relates to the possibility for the patient to express him- or herself through the use of the application. For example, app functions and automatic communications will be not generalized to patient populations but rather will be based on individual characteristics. mHealth tools of the future should be able to adapt their functioning and interfaces to previously collected data on each person’s specific features (e.g., age, sex, life cycle phase, and temporary health state, as well as attitudes, needs, and preferences). It is essential not to ask patients to perform tasks/activities that are difficult or even dangerous for them to achieve (e.g., asking patients with a cardiac illness to perform too much physical activity). Moreover, properties of applications devoted to user engagement (e.g., gamification aspects) should not be underestimated; for example, serious games have been developed with avatars designed for the user to see examples of healthy activities and be more motivated to replicate them in real life (Proteus effect) (Yee and Bailenson, 2007; Murray et al., 2013; Villani et al., 2018); such tools are also interesting resources that can be used to guarantee personalization features to users.
Examples: In the medical field, innovative approaches have been proposed to use avatars (or, better, “supermodels” as this is the term used) of the patients to include key medical components of the patient, as well as predictive analytics, so as to tailor health interventions to the individual (Brown, 2015); these could be updated with user-generated characteristics to aid in diagnosis and treatment with self-reported data (Triberti and Chirico, 2016).
Preventive
A long-term monitoring of patients’ health would make it possible to provide timely preventive interventions and improved patient involvement in preventive programs. As noted previously, such technologies present remarkable opportunities in terms of data collection and analysis, which should be further exploited in terms of aid to health care management and therapy effectiveness. Collected data may be the basis for preventive interventions, in order to modify users’ behavior and responses before problematic consequences arise. For example, engaging health apps may not only address existing problems but also help to positively change users’ behavior, attitudes, and motivation toward health care management and treatment adherence. In this sense, mHealth should not be used as a digital assistant to treatment (i.e., “virtual medicine”) but rather as an empowerment technology that directly influences patients’ everyday activities in order to promote a healthier lifestyle and prevent negative consequences of illness.
Examples: mHealth apps for prevention have been found to be effective and positively accepted by patients. For example, some of these apps make use of automated texting to reinforce healthy behavior (e.g., physical activity) or boost it when the patient is reluctant to perform it (Martin et al., 2015).
Participatory
Recent approaches to medicine highlight that the most successful interventions are those that recognize patients not as passive recipients of care but rather as active decision makers who can make use of their own social support resources (McNutt, 2004; Lucchiari et al., 2010; Cutica et al., 2014). Patient–doctor communication is fundamental in any health management process; in this sense, mobile-based technologies should not be used as a substitute for this relationship, but rather specific functions intended to promote it should be envisaged by designers and policy makers. These include Instant Messaging functions and social networking features, as well as the possibility for the patient to have a personal profile that is continually updated with the patient’s personal information. Second, peer support has been recognized as a tremendous opportunity for positive and effective health management (Fisher et al., 2012; Merolli et al., 2013): patients benefit from interaction and collaboration with other patients who are living with similar experiences and could give them useful suggestions, as well as simply sharing their experiences, in order to empower one another’s health management abilities. mHealth tools should include such opportunities by making use of social/interpersonal technologies embedded in mobile interfaces.
Examples: An integrative review (McColl et al., 2014) found that peer support (traditionally via telephone, then via mobile functions such as texting) increases engagement in wellness activities, reduces depressive symptoms, and improves social support-related coping. Studies show that, when mobile apps include features for communication with the clinician, patients use them to transmit not only medical information but also personal needs and feelings (Triberti et al., 2018).
Psycho-Cognitive
Using a user-centered design approach, apps are created on the basis of patients’ psychological characteristics, their cognitive capabilities, and their lived experience of illness. Indeed, research on health technology shows that eHealth may systematically fail when the patient’s subjective experience has not been taken into consideration from the first steps of the technology design (Triberti and Barello, 2016). These features will improve the patients’ abilities to manage their emotions, to cope with their illness, and to make decisions about their health, becoming active actors in the health management process. In other words, the design and development of advanced mHealth tools not only should make use of the tremendous opportunities offered by these tools (e.g., continual monitoring, reaching the patient wherever he/she is, integration with multiple devices, and functions by means of apps) but also should be based on the application of specific research techniques in order to (1) identify users’ characteristics, needs, and contexts of use; (2) develop efficient and personalized decision support tools to help patients to make the right decisions about their health; and (3) test the technology’s effectiveness and adequacy at multiple steps of their implementation in the field.
Examples: An effective self-management platform could be based on research on patients’ needs and cognitive style, by using multiple design-oriented methods (Pravettoni et al., 2015; Kondylakis et al., 2017). Regarding psycho-cognitive aspects to be included in implementation, Kondylakis et al. (2014) developed and validated ALGA-C, a web-based tool featuring a questionnaire for cancer patients (analyzing psycho-cognitive aspects ranging from personal needs to cognitive/decision making style) and a profiling mechanism. This tool enables the clinician to modulate language, communication style, and content of the subsequent encounters with the patient, in order to empower mutual understanding and collaboration. This tool is an example of automated data-gathering tools that could be adapted to mHealth technology in order to adapt the intervention to the uniqueness of the patient over time, taking into account not only his/her physical health status but also psychological processes influencing adoption.
Conclusion
Despite their increasing popularity, the literature shows that there are still significant limitations in the acceptance and long-term adoption of mHealth apps, mostly because these technologies do not take users’ needs and contexts of use into account from the first steps of design and implementation. Here, we presented a “P5 mHealth approach” as a set of suggestions (and related examples) for aspects of the mobile technologies that could be exploited in the future advanced mHealth resources (see Table 1). Rather than relying on the intrinsic properties of technologies only, health management processes should appreciate the uniqueness of patients in order to foster mHealth abilities in terms of prediction, personalization, prevention, participatory features, and the psycho-cognitive uniqueness of the individual. Future studies in the field would implement such suggestions in design, as well as to test their utility for identifying possible improvements for the already-existing mHealth tools that are hindered by adoption issues.
Author Contributions
AG conceived the ideas presented in the article and wrote the first draft. KM and ST contributed with discussion on the ideas presented in the article and edited the manuscript. VS and LS performed relevant bibliographic search and contributed to revisions. GP supervised the whole process and contributed with important intellectual content.
Funding
This project had received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 643529. This presentation reflects the authors’ view. The Commission is not responsible for any use that may be made of the information it contains.
Conflict of Interest Statement
The reviewer SS declared a past co-authorship with one of the authors ST to the handling Editor.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
Agree, E. M., King, A. C., Castro, C. M., Wiley, A., and Borzekowski, D. L. (2015). “It’s got to be on this page”: age and cognitive style in a study of online health information seeking. J. Med. Internet Res. 17:e79. doi: 10.2196/jmir.3352
Auffray, C., Charron, D., and Hood, L. (2010). Predictive, preventive, personalized and participatory medicine: back to the future. Genome Med. 2:57. doi: 10.1186/gm178
Barello, S., Triberti, S., Graffigna, G., Libreri, C., Serino, S., Hibbard, J., et al. (2016). eHealth for patient engagement: a systematic review. Front. Psychol. 6:2013. doi: 10.3389/fpsyg.2015.02013
Beiwinkel, T., Hey, S., Bock, O., and Rössler, W. (2017). supportive mental health self-monitoring among smartphone users with psychological distress: protocol for a fully mobile randomized controlled trial. Front. Public Health 5:249. doi: 10.3389/fpubh.2017.00249
Benson, S. G., and Dundis, S. P. (2003). Understanding and motivating health care employees: integrating Maslow’s hierarchy of needs, training and technology. J. Nurs. Manag. 11, 315–320. doi: 10.1046/j.1365-2834.2003.00409.x
Bert, F., Giacometti, M., Gualano, M. R., and Siliquini, R. (2014). Smartphones and health promotion: a review of the evidence. J. Med. Syst. 38:9995. doi: 10.1007/s10916-013-9995-7
Bolle, S., Romijn, G., Smets, E. M., Loos, E. F., Kunneman, M., and van Weert, J. C. (2016). Older cancer patients’ user experiences with web-based health information tools: a think-aloud study. J. Med. Internet Res. 18:e208. doi: 10.2196/jmir.5618
Børøsund, E., Cvancarova, M., Ekstedt, M., Moore, S. M., and Ruland, C. M. (2013). How user characteristics affect use patterns in web-based illness management support for patients with breast and prostate cancer. J. Med. Internet Res. 15:e34. doi: 10.2196/jmir.2285
Brown, S. A. (2015). Building supermodels: emerging patient avatars for use in precision and systems medicine. Front. Physiol. 6:318. doi: 10.3389/fphys.2015.00318
Cassidy, S., and Eachus, P. (2002). Developing the computer user self-efficacy (CUSE) scale: investigating the relationship between computer self-efficacy, gender and experience with computers. J. Edu. Comput. Res. 26, 133–153. doi: 10.2190/JGJR-0KVL-HRF7-GCNV
Castelnuovo, G., Pietrabissa, G., Manzoni, G. M., Corti, S., Ceccarini, M., Borrello, M., et al. (2015a). Chronic care management of globesity: promoting healthier lifestyles in traditional and mHealth based settings. Front. psychol. 6:1557. doi: 10.3389/fpsyg.2015.01557
Castelnuovo, G., Zoppis, I., Santoro, E., Ceccarini, M., Pietrabissa, G., Manzoni, G. M., et al. (2015b). Managing chronic pathologies with a stepped mHealth-based approach in clinical psychology and medicine. Front. psychol. 6:407. doi: 10.3389/fpsyg.2015.00407
Chih, M.-Y., Patton, T., McTavish, F., Isham, A., Judkins-Fisher, C., Atwood, A., et al. (2011). Predictive modeling of addiction lapses in a mobile health application. J. Subst. Abuse Treat. 22, 233–245. doi: 10.1016/j.jsat.2013.08.004
Christensen, H., Griffiths, K. M., and Farrer, L. (2009). Adherence in internet interventions for anxiety and depression: systematic review. J. Med. Internet Res. 11:e13. doi: 10.2196/jmir.1194
Cutica, I., Mc Vie, G., and Pravettoni, G. (2014). Personalised medicine: the cognitive side of patients. Eur. J. Intern. Med. 25, 685–688. doi: 10.1016/j.ejim.2014.07.002
Durndell, A., and Haag, Z. (2002). Computer self efficacy, computer anxiety, attitudes towards the internet and reported experience with the Internet, by gender, in an East European sample. Comput. Hum. Behav. 18, 521–535. doi: 10.1016/S0747-5632(02)00006-7
Fisher, E. B., Boothroyd, R. I., Coufal, M. M., Baumann, L. C., Mbanya, J. C., Rotheram-Borus, M. J., et al. (2012). Peer support for self-management of diabetes improved outcomes in international settings. Health Aff. 31, 130–139. doi: 10.1377/hlthaff.2011.0914
Fontecha, J., Hervás, R., and Bravo, J. (2015). “A sensorized and health aspect-based framework to improve the continuous monitoring on diseases using smartphones and smart devices,” in Ambient Intelligence for Health, eds J. Bravo, R. Hervás, and V. Villarreal (Cham: Springer),68–73.
Free, C., Phillips, G., Galli, L., Watson, L., Felix, L., Edwards, P., et al. (2013). The effectiveness of mobile-health technology-based health behaviour change or disease management interventions for health care consumers: a systematic review. PLoS Med. 10:e1001362. doi: 10.1371/journal.pmed.1001362
Goel, M. S., Brown, T. L., Williams, A., Cooper, A. J., Hasnain-Wynia, R., and Baker, D. W. (2011). Patient reported barriers to enrolling in a patient portal. J. Am. Med. Inform. Assoc. 18(Suppl. 1), i8–i12. doi: 10.1136/amiajnl-2011-000473
Gorini, A., Masiero, M., and Pravettoni, G. (2016). Patient decision aids for prevention and treatment of cancer diseases: are they really personalised tools? Eur. J. Cancer Care 25, 936–960. doi: 10.1111/ecc.12451
Gorini, A., Mazzocco, K., Gandini, S., Munzone, E., McVie, G., and Pravettoni, G. (2015). Development and psychometric testing of a breast cancer patient-profiling questionnaire. Breast Cancer 7:133. doi: 10.2147/BCTT.S80014
Gorini, A., and Pravettoni, G. (2011). P5 medicine: a plus for a personalized approach to oncology. Nat. Rev. Clin. Oncol. 8:444. doi: 10.1038/nrclinonc.2010.227-c1
Grimsbø, G. H., Engelsrud, G. H., Ruland, C. M., and Finset, A. (2012). Cancer patients’ experiences of using an interactive health communication application (IHCA). Int. J. Qual. Stud. Health Well-Being 7:15511. doi: 10.3402/qhw.v7i0.15511
Guo, X., Zhang, X., and Sun, Y. (2016). The privacy–personalization paradox in mHealth services acceptance of different age groups. Electron. Commer. Res. Appl. 16, 55–65. doi: 10.1016/j.elerap.2015.11.001
Gurman, T. A., Rubin, S. E., and Roess, A. A. (2012). Effectiveness of mHealth behavior change communication interventions in developing countries: a systematic review of the literature. J. Health Commun. 17(Suppl. 1), 82–104. doi: 10.1080/10810730.2011.649160
Gysels, M., and Higginson, I. J. (2007). Interactive technologies and videotapes for patient education in cancer care: systematic review and meta-analysis of randomised trials. Support. Care Cancer 15, 7–20. doi: 10.1007/s00520-006-0112-z
Hamine, S., Gerth-Guyette, E., Faulx, D., Green, B. B., and Ginsburg, A. S. (2015). Impact of mHealth chronic disease management on treatment adherence and patient outcomes: a systematic review. J. Med. Internet Res. 17:e52. doi: 10.2196/jmir.3951
Hood, L., and Flores, M. (2012). A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory. New biotechnol. 29, 613–624. doi: 10.1016/j.nbt.2012.03.004
Hood, L., and Friend, S. H. (2011). Predictive, personalized, preventive, participatory (P4) cancer medicine. Nat. Rev. Clin. Oncol. 8:184–187. doi: 10.1038/nrclinonc.2010.227
Hood, M., Wilson, R., Corsica, J., Bradley, L., Chirinos, D., and Vivo, A. (2016). What do we know about mobile applications for diabetes self-management? A review of reviews. J. Behav. Med. 39, 981–994. doi: 10.1007/s10865-016-9765-3
Jacobs, R. J., Lou, J. Q., Ownby, R. L., and Caballero, J. (2016). A systematic review of eHealth interventions to improve health literacy. Health Inform. J. 22, 81–98. doi: 10.1177/1460458214534092
Kessel, K. A., Vogel, M. M., Kessel, C., Bier, H., Biedermann, T., Friess, H., et al. (2017). Mobile health in oncology: a patient survey about app-assisted cancer care. JMIR Mhealth Uhealth. 5:e81. doi: 10.2196/mhealth.7689
Kim, D., and Chang, H. (2007). Key functional characteristics in designing and operating health information websites for user satisfaction: an application of the extended technology acceptance model. Int. J. Med. Inform. 76, 790–800. doi: 10.1016/j.ijmedinf.2006.09.001
Kondylakis, H., Bucur, A., Dong, F., Renzi, C., Manfrinati, A., Graf, N., et al. (2017). IManagecancer: developing a platform for empowering patients and strengthening self-management in cancer diseases. Paper presented at the IEEE 30th International Symposium on Computer-Based Medical Systems (CBMS), Piscataway, NJ, 755–760. doi: 10.1109/CBMS.2017.62
Kondylakis, H., Kazantzaki, E., Koumakis, L., Genitsaridi, I., Marias, K., Gorini, A., et al. (2014). Development of interactive empowerment services in support of personalised medicine. Ecancermedicalscience 8:400. doi: 10.3332/ecancer.2014.400
Kondylakis, H., Koumakis, L., Tsiknakis, M., Marias, K., Genitsaridi, E., Pravettoni, G., et al. (2013). “Smart recommendation services in support of patient empowerment and personalized medicine,” in Multimedia Services in Intelligent Environments, eds G. Tsihrintzis, M. Virvou, and L. Jain (Heidelberg: Springer), 39–61.
Kumar, S., Nilsen, W. J., Abernethy, A., Atienza, A., Patrick, K., Pavel, M., et al. (2013). Mobile health technology evaluation: the mHealth evidence workshop. Am. J. Prev. Med. 45, 228–236. doi: 10.1016/j.amepre.2013.03.017
Lee, H., Ghebre, R., Le, C., Jang, Y. J., Sharratt, M., and Yee, D. (2017). Mobile phone multilevel and multimedia messaging intervention for breast cancer screening: pilot randomized controlled trial. JMIR Mhealth Uhealth 5:e154. doi: 10.2196/mhealth.7091
Loerzel, V., Clochesy, J., and Geddie, P. (2018). Using a community advisory board to develop a serious game for older adults undergoing treatment for cancer. Appl. Nurs. Res. 39, 207–210. doi: 10.1016/j.apnr.2017.11.030
Lucchiari, C., Botturi, A., and Pravettoni, G. (2010). The impact of decision models on self-perceived quality of life: a study on brain cancer patients. Ecancermedicalscience 4:187. doi: 10.3332/ecancer.2010.187
Martin, S. S., Feldman, D. I., Blumenthal, R. S., Jones, S. R., Post, W. S., McKibben, R. A., et al. (2015). mActive: a randomized clinical trial of an automated mHealth intervention for physical activity promotion. J. Am. Heart Assoc. 4:e002239. doi: 10.1161/JAHA.115.002239
Mattsson, S., Olsson, E. M. G., Johansson, B., and Carlsson, M. (2017). Health-related internet use in people with cancer: results from a cross-sectional study in two outpatient clinics in Sweden. J. Med. Internet Res. 19:e163. doi: 10.2196/jmir.6830
McColl, L. D., Rideout, P. E., Parmar, T. N., and Abba-aji, A. (2014). Peer support intervention through mobile application: an integrative literature review and future directions. Can, Psychol. 55, 250–257. doi: 10.1037/a0038095
McKay, F. H., Cheng, C., Wright, A., Shill, J., Stephens, H., and Uccellini, M. (2016). Evaluating mobile phone applications for health behaviour change: a systematic review. J. Telemed. Telecare 24, 22–30. doi: 10.1177/1357633X16673538
McNutt, R. A. (2004). Shared medical decision making: problems, process, progress. JAMA 292, 2516–2518. doi: 10.1001/jama.292.20.2516
Merolli, M., Gray, K., and Martin-Sanchez, F. (2013). Health outcomes and related effects of using social media in chronic disease management: a literature review and analysis of affordances. J. Biomed. Inform. 46, 957–969. doi: 10.1016/j.jbi.2013.04.010
Miller, D. P. Jr., Weaver, K. E., Case, L. D., Babcock, D., Lawler, D., Denizard-Thompson, N., et al. (2017). Usability of a novel mobile health iPad app by vulnerable populations. JMIR Mhealth Uhealth 5:e43. doi: 10.2196/mhealth.7268
Mirkovic, J., Kaufman, D. R., and Ruland, C. M. (2014). Supporting cancer patients in illness management: usability evaluation of a mobile app. JMIR Mhealth Uhealth 2:e33. doi: 10.2196/mhealth.3359
Mohammadzadeh, N., and Safdari, R. (2014). Patient monitoring in mobile health: opportunities and challenges. Med. Arch. 68:57.
Mohr, D. C., Cuijpers, P., and Lehman, K. (2011). Supportive accountability: a model for providing human support to enhance adherence to eHealth interventions. J. Med. Internet Res. 13:e30. doi: 10.2196/jmir.1602
Mun, Y. Y., and Hwang, Y. (2003). Predicting the use of web-based information systems: self-efficacy, enjoyment, learning goal orientation, and the technology acceptance model. Int. J. Hum. Comput. Stud. 59, 431–449. doi: 10.1016/S1071-5819(03)00114-9
Murray, T., Hardy, D., Spruijt-Metz, D., Hekler, E., and Raij, A. (2013). “Avatar interfaces for biobehavioral feedback,” in Proceedings of the International Conference of Design, User Experience, and Usability, (Berlin: Springer), 424–434. doi: 10.1007/978-3-642-39241-2_47
Nijland, N., van Gemert-Pijnen, J. E., Kelders, S. M., Brandenburg, B. J., and Seydel, E. R. (2011). Factors influencing the use of a Web-based application for supporting the self-care of patients with type 2 diabetes: a longitudinal study. J. Med. Internet Res. 13:e71. doi: 10.2196/jmir.1603
Os, J., Verhagen, S., Marsman, A., Peeters, F., Bak, M., Marcelis, M., et al. (2017). The experience sampling method as an mHealth tool to support self-monitoring, self-insight, and personalized health care in clinical practice. Depress. Anxiety 34, 481–493. doi: 10.1002/da.22647
Pagliari, C. (2007). Design and evaluation in eHealth: challenges and implications for an interdisciplinary field. J. Med. Internet Res. 9:e15. doi: 10.2196/jmir.9.2.e15
Pravettoni, G., Folgieri, R., and Lucchiari, C. (2015). “Cognitive science in telemedicine: from psychology to artificial intelligence,” in Tele-oncology, eds G. Gatti, G. Pravettoni, and F. Capello (Cham: Springer), 5–22.
Pravettoni, G., and Gorini, A. (2011). A P5 cancer medicine approach: why personalized medicine cannot ignore psychology. J. Eval. Clin. Pract. 17, 594–596. doi: 10.1111/j.1365-2753.2011.01709.x
Pravettoni, G., Mazzocco, K., Gorini, A., and Curigliano, G. (2016). Understanding cognitive processes behind acceptance or refusal of phase I trials. Crit. Rev. Oncol. Hematol. 100, 69–73. doi: 10.1016/j.critrevonc.2016.01.023
Price, N. D., Edelman, L. B., Lee, I., Yoo, H., Hwang, D., Carlson, G., et al. (2009). “Systems biology and systems medicine,” in Essentials of Genomic and Personalized Medicine, eds G. S. Ginsburg and H. F. Willard (Maryland Heights: Elsevier Academic Press), 131–141.
Renzi, C., Fioretti, C., Oliveri, S., Mazzocco, K., Zerini, D., Alessandro, O., et al. (2017). A qualitative investigation on patient empowerment in prostate cancer. Front. Psychol. 8:1215. doi: 10.3389/fpsyg.2017.01215
Ruland, C. M., Maffei, R. M., Børøsund, E., Krahn, A., Andersen, T., and Grimsbø, G. H. (2013). Evaluation of different features of an eHealth application for personalized illness management support: cancer patients’ use and appraisal of usefulness. Int. J. Med. Inform. 82, 593–603. doi: 10.1016/j.ijmedinf.2013.02.007
Samoocha, D., Bruinvels, D. J., Elbers, N. A., Anema, J. R., and van der Beek, A. J. (2010). Effectiveness of web-based interventions on patient empowerment: a systematic review and meta-analysis. J. Med. Internet Res. 12:e23. doi: 10.2196/jmir.1286
Sathyanarayana, A., Joty, S., Fernandez-Luque, L., Ofli, F., Srivastava, J., Elmagarmid, A., et al. (2016). Impact of physical activity on sleep: a deep learning based exploration. JMIR Mhealth Uhealth 4:e125. doi: 10.2196/mhealth.6562
Stellefson, M., Hanik, B., Chaney, B., Chaney, D., Tennant, B., and Chavarria, E. A. (2011). eHealth literacy among college students: a systematic review with implications for eHealth education. J. Med. Internet Res. 13:e102. doi: 10.2196/jmir.1703
Stephens, J. D., Yager, A. M., and Allen, J. (2017). Smartphone technology and text messaging for weight loss in young adults: a randomized controlled trial. J. Cardiovasc. Nurs. 32, 39–46. doi: 10.1097/JCN.0000000000000307
Tokosi, T. O., Fortuin, J., and Douglas, T. S. (2017). The impact of mHealth interventions on breast cancer awareness and screening: systematic review protocol. JMIR Res. Protoc. 6:e246. doi: 10.2196/resprot.8043
Tomlinson, M., Rotheram-Borus, M. J., Swartz, L., and Tsai, A. C. (2013). Scaling up mHealth: where is the evidence? PLoS Med. 10:e1001382. doi: 10.1371/journal.pmed.1001382
Triberti, S., and Barello, S. (2016). The quest for engaging AmI: patient engagement and experience design tools to promote effective assisted living. J. Biomed. Inform. 63, 150–156. doi: 10.1016/j.jbi.2016.08.010
Triberti, S., Bigi, S., Rossi, M. G., Caretto, A., Laurenzi, A., Dozio, N., et al. (2018). The active ageing mobile app for diabetes self-management: first adherence data and analysis of patients’ in-app notes. Paper presented at: 7th EAI International Symposium on Pervasive Computing Paradigms for Mental Health – MindCare 2018, Boston, MA.
Triberti, S., and Chirico, A. (2016). “Healthy Avatars, Healthy People,” in Transformative Healthcare Practice through Patient Engagement, ed. G. Graffigna (Hersey, PA: IGI Global), 247–275.
Villani, D., Carissoli, C., Triberti, S., Marchetti, A., Gilli, G., and Riva, G. (2018). Videogames for emotion regulation: a systematic review. Games Health J. 7, 85–99. doi: 10.1089/g4h.2017.0108
Wangpipatwong, S., Chutimaskul, W., and Papasratorn, B. (2008). Understanding citizen’s continuance intention to use e-government website: a composite view of technology acceptance model and computer self-efficacy. Electron. J. E Gov. 6, 55–64.
Ward, R. (2013). The application of technology acceptance and diffusion of innovation models in healthcare informatics. Health Policy Technol. 2, 222–228. doi: 10.1177/1460458211435425
Wiecha, J., and Pollard, T. (2004). The interdisciplinary eHealth team: chronic care for the future. J. Med. Internet Res. 6:e22. doi: 10.2196/jmir.6.3.e22
Wu, Y. T., and Tsai, C. C. (2006). University students’ internet attitudes and internet self-efficacy: a study at three universities in Taiwan. Cyberpsychol. Behav. 9, 441–450. doi: 10.1089/cpb.2006.9.441
Keywords: mHealth, technology acceptance, P5, eHealth, patient empowerment, chronic diseases
Citation: Gorini A, Mazzocco K, Triberti S, Sebri V, Savioni L and Pravettoni G (2018) A P5 Approach to m-Health: Design Suggestions for Advanced Mobile Health Technology. Front. Psychol. 9:2066. doi: 10.3389/fpsyg.2018.02066
Received: 10 April 2018; Accepted: 08 October 2018;
Published: 31 October 2018.
Edited by:
Gianluca Castelnuovo, Università Cattolica del Sacro Cuore, ItalyReviewed by:
Silvia Serino, Università Cattolica del Sacro Cuore, ItalyMenna Price, Swansea University, United Kingdom
Copyright © 2018 Gorini, Mazzocco, Triberti, Sebri, Savioni and Pravettoni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Alessandra Gorini, alessandra.gorini@unimi.it