The following Research Topics are led by experts in their field and contribute to the scientific understanding of immunology. These Research topics are published in the peer-reviewed journal Frontiers in Immunology, as open access articles.
![Colon Polyp Removal. Endoscope inside colonoscopy for Colon polyps search. 3d render.](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/FF5A6366-D19D-4283-B39F68612FC0E2C5/thul-43553CB3-5D55-4586-BE5103448A2B8C70.png)
Checkpoint Immunotherapy: Reshaping the Landscape of Gastrointestinal Cancer Treatment
This collection brings together leading experts and researchers in the field of oncology to explore the latest advancements, challenges, and future directions of checkpoint immunotherapy in gastrointestinal cancer treatment.
![Biopsy tissue form cold abscess of neck microscopic 40x objective view chronic granulomatous inflammation histologically consistent with tuberculosis.](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/1EEBA1AC-E209-4C85-9295962B8AA6912B/thul-64DDD675-EEFB-4A11-A987FDEF1741944D.png)
Precision Oncology in Checkpoint Immunotherapy: Leveraging Predictive Biomarkers for Personalized Treatment
This special collection seeks to provide a comprehensive resource for clinicians, researchers, and industry stakeholders invested in advancing personalized medicine approaches in checkpoint immunotherapy.
![A crowd of Mediterranean fish in the crystal clear waters of Villasimius, Sardinia, Mediterranean. Underwater photography](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/F2598B51-2778-49FA-82E434A046C132CA/thul-E98BA96A-D095-4B13-B0F0D15967495AE6.png)
Molecular Innate Immunity in Aquatic Animals and Their Response to Epidemic Diseases
Background: Aquaculture provides high-quality protein to the global population.
![T Cells attacking Cancer Cells 3D illustration](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/D597A4FE-4EED-48EA-90AD89C8C6B82D7B/thul-53FBEF4B-E27A-4AFA-B2D35CCA223CBC88.png)
Non-malignant Cells in Cancer Immune Microenvironment
The aim of the Research Topic is to focus on the characterization of subsets of non-malignant cells and the clear elucidation of their function in the cancer immune microenvironment.
![Biotechnology or biotech and study of cells and microorganisms. 3D illustration, concept of science and technology in the world of cells and microorganisms.](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/F1297A38-88E2-486A-9B87D1726957D551/thul-B9DDBE03-63C6-4144-95A6667893929D6F.png)
Community Series in Biology of C-reactive Protein: Volume II
In this Research Topic, we will consider all submissions related to the understanding of the biology of CRP.
![This Centers for Disease Control and Prevention (CDC) scientist was shown implementing molecular testing, in order to test for different types of polio. The 6-assay screening can determine which samples are polio, the specific serotype of polio, and whether they are vaccine, or wild strains.](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/3AB3C298-27ED-4F7E-AB556AB6E9E3BE7C/thul-92B1D110-0057-411B-BE8D8C6EC3D40E12.png)
Trends in Adjuvant Research and Development
This research topic aims to discuss emerging advances in the research and development of novel adjuvants, as well as to highlight the expanding knowledge in the context of immunity and vaccinology for the prevention, control, and treatment of diseases
![liver cancer](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/CC01A24E-0739-4D7D-954994EC10DDF031/thul-A42E40DD-C312-4F94-89885246BA247EA0.png)
Exploring the role of immune cells and cell therapy in liver cancer
Background: Understanding the complex interactions between tumor cells and tumor microenvironments is crucial for the rational development of effective anti-cancer treatments.
![Selective focus of CT Chest or Lung 3D rendering image for diagnosis lung diseases ,TB or tuberculosis and covid-19 .](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/5E99063C-A955-4DD8-91D5D83F6914FCEE/thul-ED2EDD4C-FC3B-438B-BF54B0269EF0AE02.png)
The Host and Pathogen Determinants of Tuberculosis Spectrum Diseases
The aim of this research topic is to stimulate discussion among investigators on various host and Mtb characteristics, that would contribute to better understanding of TB and help devise improved diagnosis and treatment options.
![Systemic Lupus Erythematosus(SLE) is a chronic disease caused by self-immunity which causes Effects on the organs in the body, especially the skin, joints, blood, kidneys and central nervous system.](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/9D2D9C86-09DC-4623-839A7BE70D94350F/thul-92535697-BDBE-4AA2-8437E49290B3F301.png)
Allergic reactions related to polyethylene glycol (PEG) and PEG-containing mRNA/LNP vaccines
Background: Inviting experts from clinical, academic, and regulatory backgrounds to focus on the challenges of PEG allergy and immunogenicity, exchange ideas, and explore potential solutions.
![Human antibody binding to human cell receptors. 3D illustration](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/2B413FC3-AAA4-4BAC-89F94995D4129FD8/thul-27C4D64E-4A56-49D3-9AF23CAD2B6666A9.png)
Advances in Immunogenicity Risk Assessment, Monitoring and Mitigation of Biologics
Background: Biologics have become essential medical treatments for many progressive, debilitating, or life-threatening diseases
![Microbiome intestine factories and microbiota. Gut health 3d render. Microvilli with factories in intestine](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/B993E7DF-DC97-4BF1-A7436461EBF95EB0/thul-B5C39084-D68E-4737-9D13A58BBD48BF71.png)
Natural Products and Intestinal Mucosal Immunity
This research topic aims to promote the research on natural products in regulating intestinal mucosal immunity to combat chronic inflammation, injured intestinal mucosa, immunometabolic disorders, tumorigenic pathologies, etc.
![T Cells attacking Cancer Cells 3D illustration](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/E5D5D5BE-64EB-48B5-97FB82625847F4B6/thul-FDD18D7B-74B8-4CD4-A5016D908488EB5C.png)
T cell Dysfunction in Aging and Chronic Inflammation: Mechanisms and Potential Therapeutic Targets
The objective of this research theme is to delve deep into the cellular and molecular cues that contribute to the impairment of T cell function in different disease conditions associated with chronic inflammation and aging.
![This image is a journal's Main Visual. Please do not use it outside journal specific assets. More information in the 'How to use Main Visuals' guide (coming soon).](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/F9AC6F68-F22F-4063-9EC2E7B9EE190CB5/1B49C0C2-2437-46FF-95EAFB1F10856E48/thul-2A9A1126-0198-4480-BBA396B6CBF3F02E.jpg)
Immunoregulation in Urological Disorders: Novel Targets and Therapies
This research topic aims to explore the immunoregulatory mechanisms involved in urological tumors, stones, and prostatitis, identify novel therapeutic targets, and propose effective treatment strategies.
![Selective focus of CT Chest or Lung 3D rendering image lateral view for diagnosis lung diseases ,TB or tuberculosis and covid-19 .](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/2127F20F-E76C-4897-9AD324D0096D180C/thul-A5764EFB-ECA3-45E0-983E758021688FCE.png)
Unravelling the Immune Fortress: Decoding the Protective Immune Mechanisms Against Lower Respiratory Pathogens
Background: Bacterial or viral pathogens causing lower respiratory tract infections present significant global health challenges. Mycobacterium tuberculosis (Mtb) and the Respiratory Syncytial Virus (RSV) are key players in this infection.
![3d illustration of an activated platelets, also called thrombocytes responsible for the healing and closure of wounds](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/8338E0EA-C010-426B-979274AE920810C2/thul-C4904C33-0431-49AD-94B302CD0B408F2E.png)
Community Series in Innate Immunity: Platelets and their Interaction with other Cellular Elements in Host Defense and Disease Pathogenesis - Volume II
This Research Topic aims to address the mechanisms of actions of platelets and their interactions with other cellular elements in the host system.
![Intestinal bacteria, Gut microbiome helps control intestinal digestion and the immune system, Probiotics are beneficial bacteria used to help the growth of healthy gut flora, 3d illustration](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/8F53B27C-3A9D-42E0-96CA8C49D9740F10/thul-4AA1D13B-FA42-4B0C-9214B0161B7DFC57.png)
Community Series in Interplay Between Diets, Microbiota, Bacterial Metabolites and Host for Intestinal Health and Disease: Volume II
Background: An interplay between the diet and the microbiota appears to regulate the host responses.
![Famous electric red tourist train coming down from the Jungfraujoch station(top of Europe) in Kleine Scheidegg,Bernese Oberland,Switzerland,Europe](https://d2csxpduxe849s.cloudfront.net/media/E32629C6-9347-4F84-81FEAEF7BFA342B3/1A475CB0-7564-4933-B189C75E5B7EE474/thul-BEC73865-4391-4437-980F7D83F39E821D.png)
Finding New Hope in Old Treatments: Repurposing Immunotherapy in Transplantation
This Research Topic aims to explore the intersections and commonalities between immunological mechanisms in transplantation, cancer, and autoimmune diseases.