Immunology

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Immunology

Immunology explores the various mechanisms by which our immune system protects the body against harmful pathogens. We aim to develop our understanding of this complex field, introducing research that explores novel therapies such as vaccines and immunotherapies which make the world a healthier place for us all.

The following Research Topics are led by experts in their field and contribute to the scientific understanding of immunology. These Research topics are published in the peer-reviewed journal Frontiers in Immunology, as open access articles.

Research Topics

Frontiers' Research Topics are peer-reviewed article collections around cutting-edge research themes.
Learn more about how Research topics work.

Bryonia, stem with sieve plates - microscopic cross section cut of a plant stem - dark field

Immune Challenges and Innovations in Lipid-Encapsulated Biotherapeutics

The field of non-viral encapsulated biotherapeutics is rapidly evolving, with significant advancements in lipid-based nanovectors such as liposomes, lipoplexes, lipid-polymer hybrid nanoparticles, and lipid nanoparticles (LNPs).

Immune System: Macrophages, Dendritic Cells, and White Blood Cells Defend Against Bacterial Infections and Pathogens

Implications of Senescence in Cancer Immunology

The concept of permanent and irreversible cell cycle arrest (senescence) was initially regarded as a defence mechanism against tumour progression.

Varicella zoster virus. Double-stranded DNA genome structure, capsid, envelope. Virus causing chickenpox, skin blisters hives sores, shingles. Herpes infection control, vaccine. 3D medical illustratio; Shutterstock ID 2480859429; purchase_order: Bynder; job: ; client: ; other:

Immunological Mechanisms, Clinical Presentations, and Outcomes of Neurological Toxicities Induced by Immune Checkpoint Inhibitors

Immunotherapy has revolutionized cancer treatment, notably through the use of immune checkpoint inhibitors (ICIs) that target molecules such as CTLA-4 and PD-1/PD-L1.

Cods (Gadus morhua) and saithes (Pollachius virens) fish in the Atlantic Sea Park in Alesund, Norway

Molecular and Cellular Insights into Fish Immunity: Adaptations to Pathogens and Environmental Challenges

Fish immunity is a critical area of study due to the ecological and economic importance of fish in aquatic ecosystems and aquaculture industries.

Medium shot of scientist working at computer

Role of bioinformatics and AI in understanding inflammation and immune microenvironment dynamics

Bioinformatics and artificial intelligence are pivotal in the current transformation of biomedical research, particularly in the field of inflammatory diseases.

Malignant effusion: Pleural fluid pathology (cytology) of lung (pulmonary) adenocarcinoma, a type of non small cell cancer (carcinoma). Pap stain.

The Role of Immune and Stromal Mediators in the Formation of Pre-metastatic and Metastatic Niches: The Gateway to Metastasis

In the realm of oncology, metastasis stands as the leading cause of mortality among cancer patients, often manifesting at diagnosis or surfacing years after initial treatment.

Female biological laboratory researcher working on biomedical experiments. Scientific genetics medical worker pipetting cell culture. Woman scientists utilizing microscopy, centrifuge.

HLA-G in Health and Disease: Comprehensive Insights and Future Therapeutic Directions

Human Leukocyte Antigen-G (HLA-G) is a non-classical Major Histocompatibility Complex (MHC) class I molecule involved in immunotolerance induction.

A macrophage, a large white blood cell, component of the immune system. Absorbs cellular debris, pathogens. Phagocytosis, immune and inflammatory response, defense, tissue repair. 3D scientific render; Shutterstock ID 2570833569; purchase_order: Bynder; job: ; client: ; other:

Exploring the Biology of Inflammasomes: Mechanisms, Disorders, and Therapeutic Potential

This Research Topic delves into the complex biology of inflammasomes, their roles in immune responses, and their contribution to inflammatory disorders.

Probiotics, bacteria on white background. Bacteria and microorganisms. Microscopic probiotics, bacterial flora; Shutterstock ID 2416852323; purchase_order: Bynder; job: ; client: ; other:

Role of the Microbiome in Vector-Borne Diseases: Pathogen Transmission to Therapeutic Strategies

Vector-borne diseases contribute to approximately 17% of the global infectious disease burden and lead to over 700,000 deaths annually.

Diffuse proliferative glomerulonephritis, DPGN, light micrograph, photo under microscope

The Function and Regulation of T Cell Subsets in Inflammatory Disease

T cell populations including CD4+ helper T cells, CD8+ cytotoxic T cells and Foxp3+ regulatory T cells play a critical role in controlling or promoting inflammatory disease’s progression.

Plasma Membrane Of Cell With other molecules, 3d render

Decoding the Spectrum of Plasma Cell Heterogeneity: Insights into Maturity and Longevity

Plasma cells (PCs) are the terminal differentiation stage of activated B cells and serve as crucial effector cells in humoral immunity.

A female scientist controls the operation of devices for laboratory research. Modern laboratory technologies. Medical research centrifuge.

Immune Predictive and Prognostic Biomarkers in Immuno-Oncology: Refining the Immunological Landscape of Cancer

Immunotherapy has emerged as a transformative approach in cancer treatment, harnessing the patient's immune system to combat malignancies.

Cancer Cell self destructing cancer cure treatment T-cell lymphocyte killing tumors 3D render

Immunological Aspects and Immunotherapy in Gynecologic Cancers

Gynecologic cancers, including cervical, ovarian, endometrial, vaginal, and vulvar cancers, represent a significant health burden for women globally.

Senior woman sitting in hospital room after chemotherapy.

Combination of photodynamic therapy and immunotherapy to overcome cancer resistance

Both photodynamic therapy (PDT) and immunotherapy are two of the biggest areas of cancer therapy with the potential to revolutionize healthcare.

Isolated basophils are a type of white blood cell 3d rendering

Recruitment of Leukocytes During Resolution of Inflammation

The recruitment of leukocytes is essential for the immune response, not only in initiating but also in resolving inflammation.

Cross-sectioned intestinal villi stained with PAS-hematoxylin. The mucous secretion of the goblet cells is stained with the PAS.

Immune-gut-brain axis - A Key Player in Overall Human Pathologies

Accumulating evidence highlights the relevance of microbiota-gut-brain axis in the maintenance of brain homeostasis as well as in the pathophysiology of several human disorders, including neurodegenerative

Female Scientist Sits at His Workplace in Laboratory, Uses Personal Computer. Screen Shows Analyze of DNA. I the Background Genetics Research Centre with Innovative Equipment.

Immune Regulation by Self and Non-Self: Mechanisms and Implications in Host Defense and Immunopathogenesis

This Research Topic focuses on the mechanisms of immune regulation that enable the body to distinguish self from non-self, with significant implications for host defense and immunopathogenesis.

3D Rendered Medical Illustration of Male Anatomy - Internal organs. The abdomen. Plain black background. Professional studio lighting. Lateral view.

Thoracic and Abdominal Immunology: State of the Art and Future Challenges

Thoracic and abdominal immunology is at the forefront of understanding how the immune system interacts with vital organs such as the lungs, liver, and digestive tract.

Bryonia, stem with sieve plates - microscopic cross section cut of a plant stem - dark field

Immune Challenges and Innovations in Lipid-Encapsulated Biotherapeutics

The field of non-viral encapsulated biotherapeutics is rapidly evolving, with significant advancements in lipid-based nanovectors such as liposomes, lipoplexes, lipid-polymer hybrid nanoparticles, and lipid nanoparticles (LNPs).

Immune System: Macrophages, Dendritic Cells, and White Blood Cells Defend Against Bacterial Infections and Pathogens

Implications of Senescence in Cancer Immunology

The concept of permanent and irreversible cell cycle arrest (senescence) was initially regarded as a defence mechanism against tumour progression.

Varicella zoster virus. Double-stranded DNA genome structure, capsid, envelope. Virus causing chickenpox, skin blisters hives sores, shingles. Herpes infection control, vaccine. 3D medical illustratio; Shutterstock ID 2480859429; purchase_order: Bynder; job: ; client: ; other:

Immunological Mechanisms, Clinical Presentations, and Outcomes of Neurological Toxicities Induced by Immune Checkpoint Inhibitors

Immunotherapy has revolutionized cancer treatment, notably through the use of immune checkpoint inhibitors (ICIs) that target molecules such as CTLA-4 and PD-1/PD-L1.

Cods (Gadus morhua) and saithes (Pollachius virens) fish in the Atlantic Sea Park in Alesund, Norway

Molecular and Cellular Insights into Fish Immunity: Adaptations to Pathogens and Environmental Challenges

Fish immunity is a critical area of study due to the ecological and economic importance of fish in aquatic ecosystems and aquaculture industries.

Medium shot of scientist working at computer

Role of bioinformatics and AI in understanding inflammation and immune microenvironment dynamics

Bioinformatics and artificial intelligence are pivotal in the current transformation of biomedical research, particularly in the field of inflammatory diseases.

Malignant effusion: Pleural fluid pathology (cytology) of lung (pulmonary) adenocarcinoma, a type of non small cell cancer (carcinoma). Pap stain.

The Role of Immune and Stromal Mediators in the Formation of Pre-metastatic and Metastatic Niches: The Gateway to Metastasis

In the realm of oncology, metastasis stands as the leading cause of mortality among cancer patients, often manifesting at diagnosis or surfacing years after initial treatment.

Female biological laboratory researcher working on biomedical experiments. Scientific genetics medical worker pipetting cell culture. Woman scientists utilizing microscopy, centrifuge.

HLA-G in Health and Disease: Comprehensive Insights and Future Therapeutic Directions

Human Leukocyte Antigen-G (HLA-G) is a non-classical Major Histocompatibility Complex (MHC) class I molecule involved in immunotolerance induction.

A macrophage, a large white blood cell, component of the immune system. Absorbs cellular debris, pathogens. Phagocytosis, immune and inflammatory response, defense, tissue repair. 3D scientific render; Shutterstock ID 2570833569; purchase_order: Bynder; job: ; client: ; other:

Exploring the Biology of Inflammasomes: Mechanisms, Disorders, and Therapeutic Potential

This Research Topic delves into the complex biology of inflammasomes, their roles in immune responses, and their contribution to inflammatory disorders.

Probiotics, bacteria on white background. Bacteria and microorganisms. Microscopic probiotics, bacterial flora; Shutterstock ID 2416852323; purchase_order: Bynder; job: ; client: ; other:

Role of the Microbiome in Vector-Borne Diseases: Pathogen Transmission to Therapeutic Strategies

Vector-borne diseases contribute to approximately 17% of the global infectious disease burden and lead to over 700,000 deaths annually.

Diffuse proliferative glomerulonephritis, DPGN, light micrograph, photo under microscope

The Function and Regulation of T Cell Subsets in Inflammatory Disease

T cell populations including CD4+ helper T cells, CD8+ cytotoxic T cells and Foxp3+ regulatory T cells play a critical role in controlling or promoting inflammatory disease’s progression.

Plasma Membrane Of Cell With other molecules, 3d render

Decoding the Spectrum of Plasma Cell Heterogeneity: Insights into Maturity and Longevity

Plasma cells (PCs) are the terminal differentiation stage of activated B cells and serve as crucial effector cells in humoral immunity.

A female scientist controls the operation of devices for laboratory research. Modern laboratory technologies. Medical research centrifuge.

Immune Predictive and Prognostic Biomarkers in Immuno-Oncology: Refining the Immunological Landscape of Cancer

Immunotherapy has emerged as a transformative approach in cancer treatment, harnessing the patient's immune system to combat malignancies.

Cancer Cell self destructing cancer cure treatment T-cell lymphocyte killing tumors 3D render

Immunological Aspects and Immunotherapy in Gynecologic Cancers

Gynecologic cancers, including cervical, ovarian, endometrial, vaginal, and vulvar cancers, represent a significant health burden for women globally.

Senior woman sitting in hospital room after chemotherapy.

Combination of photodynamic therapy and immunotherapy to overcome cancer resistance

Both photodynamic therapy (PDT) and immunotherapy are two of the biggest areas of cancer therapy with the potential to revolutionize healthcare.

Isolated basophils are a type of white blood cell 3d rendering

Recruitment of Leukocytes During Resolution of Inflammation

The recruitment of leukocytes is essential for the immune response, not only in initiating but also in resolving inflammation.

Cross-sectioned intestinal villi stained with PAS-hematoxylin. The mucous secretion of the goblet cells is stained with the PAS.

Immune-gut-brain axis - A Key Player in Overall Human Pathologies

Accumulating evidence highlights the relevance of microbiota-gut-brain axis in the maintenance of brain homeostasis as well as in the pathophysiology of several human disorders, including neurodegenerative

Female Scientist Sits at His Workplace in Laboratory, Uses Personal Computer. Screen Shows Analyze of DNA. I the Background Genetics Research Centre with Innovative Equipment.

Immune Regulation by Self and Non-Self: Mechanisms and Implications in Host Defense and Immunopathogenesis

This Research Topic focuses on the mechanisms of immune regulation that enable the body to distinguish self from non-self, with significant implications for host defense and immunopathogenesis.

3D Rendered Medical Illustration of Male Anatomy - Internal organs. The abdomen. Plain black background. Professional studio lighting. Lateral view.

Thoracic and Abdominal Immunology: State of the Art and Future Challenges

Thoracic and abdominal immunology is at the forefront of understanding how the immune system interacts with vital organs such as the lungs, liver, and digestive tract.