Recent Advances in Cancer Biomarkers Detection in Biological Samples

About this Research Topic

Background

There have been great advances in the field of biosensors for cancer biomarkers detection. Biosensor technologies, including DNA chips, protein chips, microfluidics, and lateral flow membrane strips, are cutting-edge technologies that enable efficient detection of various biomarkers in the sub-nanomolar range. Advances in surface chemistry modification and biomolecule conjugation have broadened the applications of biosensors for the detection and quantification of biomarker proteins and nucleic acids. Nucleic acid microarrays and protein microarrays have provided opportunities for multiplex cancer biomarkers detection. By comparison, microfluidic and lateral flow immunoassays have paved the way for point-of-care diagnosis. However, the early cancer identification, even before the appearance of symptoms, is still a distant goal.

In this article collection, we will focus on the cancer biomarkers detection, especially DNA, RNA, exosomes, antigen, antibody, or small molecules in biological samples. The emerging results of these topics will provide an opportunity to better study and improve the processes of diagnosis and treatment, and will allow to increase survival rates. In fact, new advances in biosensor technologies will enable detection of stage 0-1 cancers where the survival rates are close to 100%. Therefore, this Research Topic focuses on recent developments in biosensors that allow sensitive and highly specific detection of cancer biomarkers.

Furthermore, we are interested on innovative and groundbreaking Nanomaterials-Based Biosensors, including wearable technologies, paper-based detection strategies, microfluidics and micro/nano-scale sensors for cancer biomarker’s detection. Moreover, we highlight the application of unique materials, nanomaterials, polymers, among others, that allow sensitive and highly specific detection. In recent years, nanomaterials have been widely used due to their tunable size, shape, and composition. They are used to immobilize biorecognition elements or as markers for signal generation, transduction and amplification. Still, extensive research is required to improve the sensitivity, efficiency, and specificity of detections in complex biological matrices.

We welcome Original Research, Review, Mini Review and Perspective articles in Detection of cancer biomarkers in biological samples, including but not limited to following themes:
• Nanomaterials-Based Biosensors
• Paper-based detection strategies
• Microfluidics and micro/nano-scale sensors

Keywords: Cancer Biomarker, Microfluidics, Biosensors, Nanomaterials, Wearable technologies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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