Stimuli-Responsive Lipid-Bioactive Conjugate-Based Nanocarriers: a Smart Approach in Biomaterial Applications

About this Research Topic

Background

The development of stimuli-responsive lipid-bioactive conjugate-based nanocarriers (LBCNs) has emerged as a promising strategy in biomaterial applications. These nanocarriers are designed to respond to specific environmental cues, such as changes in pH, temperature, or redox potential, allowing for targeted delivery and controlled release of the bioactive. The lipid-bioactive conjugates used in these nanocarriers are composed of a lipid moiety and one or more bioactive molecules, such as a drug, diagnostic/imaging moiety, peptide, or protein, that can interact with biological targets. These conjugates offer a programmed homing of bioactive to desired targeting and therapeutic or theragnostic activity within a single entity. The direct embodiment of bioactive suffers from compromised loading of the payload and undue loss of the bioactive leading to unwarranted toxicity issues. Furthermore, the nanocarrier system can be designed with a variety of surface modifications, such as targeting moieties, to further enhance specificity and efficacy.

This Research Topic will explore the evolving status of research on stimuli-responsive lipid-bioactive conjugate-based nanocarriers, including their design, synthesis, and biopharmaceutical applications. Subjects of interest include the development of new lipid-bioactive conjugates, characterization of their physicochemical properties, and in vitro and in vivo evaluation of their efficacy in drug/vaccine delivery. The prime focus will be on important aspects such as designing the lipid-bioactive tethered nanocarriers for specific routes of administration and their molecular interactions with biological membranes, immunotherapeutics, vaccines, personalized medicine, biopharmaceutical applications, tumor targeting, site-directed diagnosis or imaging, theragnosis and regenerative medicine as well. The Topic will also explore the challenges and opportunities associated with the translation of these nanocarriers from the bench to the clinic, including regulatory considerations and commercialization strategies. This Research Topic aims to provide a comprehensive update on the current state of research in this exciting field and to stimulate further advancements in the development of bioengineered nanocarriers to overcome the unmet needs of biopharmaceuticals.

Tentative titles

1. Development of lipid conjugates: Design principles and pharmaceutical and biomedical applications
2. Designing of lipid-bioactive tethered nanocarriers for specific routes of administration
3. A molecular perspective on interactions between lipid-based formulations and biological membranes
4. Rational design of stimuli-responsive lipid bioactive conjugates for targeted drug delivery
5. Lipid-bioactive conjugate-based nanocarriers for enhanced delivery of immunotherapeutics and vaccines
6. Personalized treatment using lipid-drug conjugate formulations for infectious diseases
7. Multifunctional lipid-bioactive conjugate for responsive biopharmaceutical applications: an overview of current applications and future directions
8. Tailored lipid-drug conjugates for the targeted drug delivery to the tumor microenvironment
9. Stimuli-responsive lipid-anchored bioactive-based formulations in regenerative medicine
10. An emerging landscape of site-directed lipid-diagnostic or imaging agent-based nanocarriers
11. Clinical, regulatory, and commercial aspects of lipid-bioactive conjugated delivery vehicles

Keywords: nanocarriers, stimuli-responsive, lipid-bioactive conjugate, biomaterial applications, immunotherapeutics, biopharmaceutical applications, tumor targeting, theragnosis, site-directed diagnosis or imaging, regenerative medicine

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