Although the treatment has greatly progressed, the mortality of cardiovascular diseases remains the leading cause of death worldwide. Serious cardiovascular diseases, e.g., myocardial infarction, heart failure, cardiac dysrhythmias, and stroke, are resulted from cardiovascular remodeling secondary to the cardiovascular risk factors, including hypertension, atherosclerosis, cigarette smoking, diabetes mellitus, hyperlipidemia, aging, etc. Cardiac remodeling involves a series of molecular, cellular, and interstitial alterations, which manifest clinically as changes in size, mass, geometry, and function of the heart. In addition, vascular remodeling is an active process of structural alteration involving vascular wall thickening and lumen stenosis due to endothelial injury, vascular smooth muscle cell proliferation, and matrix deposition. This results in atherosclerosis and/or stenosis followed by myocardial infarction, stroke, etc. Thus, studies on the mechanism of cardiovascular remodeling and new therapeutic approaches are important scientifically and clinically.
Cardiovascular remodeling is a response of specific cardiovascular cells, including cardiomyocytes, endothelial, smooth muscle cells, and interstitial cells, to noxious hemodynamic, metabolic, and inflammatory stimuli. The remodeling may initially be functional, compensatory, and adaptive, but it progresses to structural alterations that become pathogenic when the damaging stimuli are sustained. The mechanism of cardiovascular remodeling is complex, and recent studies focus on improving and/or reversing the remodeling by clarifying molecular mechanisms and identifying novel therapies. Pharmacological anti-remodeling, RNA-based (long non-coding RNA and microRNA) treatment, cell-based (iPS) cardiac repair, and cell-free exosome approaches have been shown to improve cardiovascular remodeling alongside proangiogenic, pro-survival, proliferative, and immunogenic factors, stimulating endogenous proliferative potential of cardiomyocytes. However, though advanced studies have progressed, the prognosis of the affected patients remains poor. Therefore, understanding novel mechanisms, identifying remodeling biomarkers, and developing new therapeutic drugs and approaches can lead to new therapeutic options for treating patients with cardiovascular diseases.
This Research Topic entitled “Cardiovascular Remodeling” is open to studies exploring molecular mechanisms, drug therapy, and cell and/or non-cell therapies to improve and/or reverse cardiovascular remodeling from basic research to clinical translational research.
The Research Topic accepts articles in the following categories: Original Research, Reviews, Methodology, and Technique reports, including, but not limited to, any of the following topics.
Frontiers invited experts in the field as contributing editors to bring together the latest research from experts in the field to advance in-depth research into the mechanisms of cardiovascular remodeling, as well as the development of approaches and drugs for reversing/improving cardiovascular remodeling.
• Molecular mechanisms of cardiac and/or vascular remodeling
• Novel molecular drug targets for improving cardiac and/or vascular remodeling
• Prevention and treatment of cardiovascular remodeling using well-defined single-compounds
• Stem cell therapy for cardiac and/or vascular remodeling
• Exosome therapy for cardiac and/or vascular remodeling
• Non-coding RNA therapy for cardiovascular remodeling
• Methodology and Technique for the study of cardiac and/or vascular remodeling
Although the treatment has greatly progressed, the mortality of cardiovascular diseases remains the leading cause of death worldwide. Serious cardiovascular diseases, e.g., myocardial infarction, heart failure, cardiac dysrhythmias, and stroke, are resulted from cardiovascular remodeling secondary to the cardiovascular risk factors, including hypertension, atherosclerosis, cigarette smoking, diabetes mellitus, hyperlipidemia, aging, etc. Cardiac remodeling involves a series of molecular, cellular, and interstitial alterations, which manifest clinically as changes in size, mass, geometry, and function of the heart. In addition, vascular remodeling is an active process of structural alteration involving vascular wall thickening and lumen stenosis due to endothelial injury, vascular smooth muscle cell proliferation, and matrix deposition. This results in atherosclerosis and/or stenosis followed by myocardial infarction, stroke, etc. Thus, studies on the mechanism of cardiovascular remodeling and new therapeutic approaches are important scientifically and clinically.
Cardiovascular remodeling is a response of specific cardiovascular cells, including cardiomyocytes, endothelial, smooth muscle cells, and interstitial cells, to noxious hemodynamic, metabolic, and inflammatory stimuli. The remodeling may initially be functional, compensatory, and adaptive, but it progresses to structural alterations that become pathogenic when the damaging stimuli are sustained. The mechanism of cardiovascular remodeling is complex, and recent studies focus on improving and/or reversing the remodeling by clarifying molecular mechanisms and identifying novel therapies. Pharmacological anti-remodeling, RNA-based (long non-coding RNA and microRNA) treatment, cell-based (iPS) cardiac repair, and cell-free exosome approaches have been shown to improve cardiovascular remodeling alongside proangiogenic, pro-survival, proliferative, and immunogenic factors, stimulating endogenous proliferative potential of cardiomyocytes. However, though advanced studies have progressed, the prognosis of the affected patients remains poor. Therefore, understanding novel mechanisms, identifying remodeling biomarkers, and developing new therapeutic drugs and approaches can lead to new therapeutic options for treating patients with cardiovascular diseases.
This Research Topic entitled “Cardiovascular Remodeling” is open to studies exploring molecular mechanisms, drug therapy, and cell and/or non-cell therapies to improve and/or reverse cardiovascular remodeling from basic research to clinical translational research.
The Research Topic accepts articles in the following categories: Original Research, Reviews, Methodology, and Technique reports, including, but not limited to, any of the following topics.
Frontiers invited experts in the field as contributing editors to bring together the latest research from experts in the field to advance in-depth research into the mechanisms of cardiovascular remodeling, as well as the development of approaches and drugs for reversing/improving cardiovascular remodeling.
• Molecular mechanisms of cardiac and/or vascular remodeling
• Novel molecular drug targets for improving cardiac and/or vascular remodeling
• Prevention and treatment of cardiovascular remodeling using well-defined single-compounds
• Stem cell therapy for cardiac and/or vascular remodeling
• Exosome therapy for cardiac and/or vascular remodeling
• Non-coding RNA therapy for cardiovascular remodeling
• Methodology and Technique for the study of cardiac and/or vascular remodeling