Mitochondrial bioenergetics and its function in tissue homeostasis is vital for regulating diverse processes with in a cell. As cell age, mitochondrial functions are often impacted by both intrinsic and extrinsic threats, more particularly by oxidative stress, which significantly alters the mitochondrial bioenergetics. Mechanistically, the steps involved in oxidative stress-led alteration of mitochondrial bioenergetics are conserved. However, the molecules involved in the oxidative stress-induced alteration of mitochondrial bioenergetics are likely to differ in tissues and cell types. It is also anticipated that the regulation of these molecules and the pathways through which they function are likely compromised during aging. Moreover, age-related decline in processes such as cell's proteomic turnover, homeostatic control mechanisms, and increasing proteotoxicity is thought to further exaggerate the risk of oxidative stress to mitochondrial energetics. These alterations could potentiate the risk of developing pathologies related to aging namely neurodegenerative diseases (Alzheimer's disease, Huntington’s disease, Amyotrophic lateral sclerosis, and Parkinson's disease) and cancer. Thus, it is critical to unravel the oxidative stress link of mitochondrial bioenergetics that potently influences and manipulates the outcome of mitochondrial activities in the aging cell. Therefore, attempts to elucidate the oxidative stress link of mitochondrial bioenergetics, warrant a more detailed and inclusive investigation.
In this series, we aim to gain new and evolving knowledge that sheds light on the role of oxidative stress in altered mitochondrial bioenergetics and its relevance with cell aging and age-related pathologies.
We invite researchers to contribute with Original Research, Review, Mini-Review, Data/Research Reports, Perspectives, and Opinions articles. Besides the promising new research on oxidative stress and mitochondrial bioenergetics, we invite submissions shedding light on their emerging role in age-related diseases.
We welcome submissions including, yet not limited to, the following sub-themes:
- Oxidative stress, quantitation and its impact on the mitochondrial bioenergetics.
- Dynamics of key proteins/effectors in oxidative stress and mitochondrial bioenergetics in cellular aging and age-related diseases
- Mitochondrial defects and their association with aging pathologies.
- Role of mitochondrial REDOX activities on cell aging.
Keywords: Cell stress, metabolism, post-translational modifications (PTMs), proliferative fate, aging, cancer, redox biology, defected metabolism, mitochondrial defects, pathologies, microRNAs
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
