The Influence of Lifestyle factors on Cancer Biology and Treatment Efficacy

About this Research Topic

Background

Cancer is the second biggest killer worldwide, second only to cardiovascular disease. The disease, and the treatment for the disease itself, both lead to significant physiological perturbations, resulting in muscle mass loss, cardiovascular dysfunction, neuropathy, and in a large number of patients, death. However, developments in physical activity and exercise science research, as well as nutrition, has resulted in a growing body of evidence demonstrating the potential for lifestyle modifications to result in disease risk reduction, as well as either improving treatment efficacy, or attenuating treatment side effects, together resulting in a better quality of life.

The goal of this Research Topic is to attract high quality research in the area of lifestyle oncology, from a wide range of research backgrounds, including cell biology using in vitro/ex vivo models, and from animal and human clinical studies to provide up-to-date evidence for the role of lifestyle modifications to reduce cancer risk and/or to improve treatment efficacy. Areas of interest include: (1) Mechanistic studies investigating the link between physical activity/diet and reduced cancer risk (2) The influence of physical activity/dietary status on cancer treatment-induced side effects, (3) Potential for exercise/physical activity/lifestyle influencing cancer treatment outcomes.

This Research Topic welcomes original research and (mini-) reviews, that provide new novel insights into the mechanisms linking lifestyle and cancer risk, and potential lifestyle interventions to provide protection against the deleterious effects of cancer treatments (such as chemotherapy/radiation). Areas to be covered in this Research Topic will include, but are not limited to:

-The mechanism(s) of exercise/dietary protection against cancer/tumor development.
-The use of exercise to promote immunological anti-cancer surveillance (e.g. NK cell-mediated cancer cell death)
-The potential for exercise/diet to alleviate chemotherapy-induced cardiovascular toxicity
-Exercise and dietary interventions to counteract cancer-associated sarcopenia
-Exercise, physical activity and lifestyle influences on treatment outcomes

Keywords: Lifestyle, cancer, chemotherapy, radiotherapy, exercise, diet, environment, tumor

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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