Metabolic Traits Associated With Neurodevelopmental and Neuropsychiatric Disorders.

Genes susceptible to neuropsychiatric or neurodevelopmental disorders share common non-psychiatric comorbidities, especially with metabolic syndromes such as obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver disease contributing to higher burden and complications. Earlier studies indicated that neuropsychiatric disorders are intertwined with neurodevelopmental disorders. It is well known that many neuropsychiatric and neurodevelopmental diseases show genetic involvement, however, the molecular components involved in the pathophysiology of these diseases are yet to be explored. The etiology of these disorders could be a combination of shared genetic, biological, psychological, and environmental insults. Altered brain metabolites strongly influence the manifestation and further exacerbate the pathophysiology of these diseases. The brain requires 20% of individual energy to plan, and execute complex cognitive, emotional, and social behavior. The probability of developing neurological disorders at the very early stage of brain development is likely, so it is important to explore genetics as a strategy to understand brain diseases.



The goal of this research topic is to expand our understanding related to interlinked association and the impact of metabolism on the neurodevelopmental basis of neuropsychiatric disorders. Thus, we persuade that with the identification of mechanistic crosstalk between neuropsychiatric disorders with metabolic disturbances, one can better understand, identify the underlying metabolic pathways and reframe the development of efficient diagnosis and treatment strategies.



We welcome original research manuscripts from a wide range of scientific approaches related to genetics, molecular, cellular, behavioral, pharmacological, and interventional both in a human and animal study about the neurobiology of neurodevelopmental, and neuropsychiatric disorders. Also, we would like to explore its link to several metabolic conditions which could be linked due to the shared genes involved with these disorders.

Keywords: Metabolic syndrome, neurodevelopment, neuropsychiatric, brain metabolism, drug target

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